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Volumn 180, Issue 6, 2012, Pages 2479-2489

Slug expression during melanoma progression

Author keywords

[No Author keywords available]

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SLUG; UVOMORULIN;

EID: 84861615174     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.02.014     Document Type: Article
Times cited : (61)

References (71)
  • 1
    • 0032525997 scopus 로고    scopus 로고
    • The Slug gene is not essential for mesoderm or neural crest development in mice
    • R. Jiang, Y. Lan, C.R. Norton, J.P. Sundberg, T. Gridley The Slug gene is not essential for mesoderm or neural crest development in mice Dev Biol 198 1998 277 285
    • (1998) Dev Biol , vol.198 , pp. 277-285
    • Jiang, R.1    Lan, Y.2    Norton, C.R.3    Sundberg, J.P.4    Gridley, T.5
  • 2
    • 0037168522 scopus 로고    scopus 로고
    • Modularity and reshuffling of Snail and Slug expression during vertebrate evolution
    • A. Locascio, M. Manzanares, M.J. Blanco, M.A. Nieto Modularity and reshuffling of Snail and Slug expression during vertebrate evolution Proc Natl Acad Sci USA 99 2002 16841 16846
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16841-16846
    • Locascio, A.1    Manzanares, M.2    Blanco, M.J.3    Nieto, M.A.4
  • 3
    • 0029585839 scopus 로고
    • Regulative response of the cranial neural tube after neural fold ablation: Spatiotemporal nature of neural crest regeneration and up-regulation of Slug
    • J. Sechrist, M.A. Nieto, R.T. Zamanian, M. Bronner-Fraser Regulative response of the cranial neural tube after neural fold ablation: spatiotemporal nature of neural crest regeneration and up-regulation of Slug Development 121 1995 4103 4115
    • (1995) Development , vol.121 , pp. 4103-4115
    • Sechrist, J.1    Nieto, M.A.2    Zamanian, R.T.3    Bronner-Fraser, M.4
  • 4
    • 0031668376 scopus 로고    scopus 로고
    • Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
    • M. Sefton, S. Sanchez, M.A. Nieto Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo Development 125 1998 3111 3121
    • (1998) Development , vol.125 , pp. 3111-3121
    • Sefton, M.1    Sanchez, S.2    Nieto, M.A.3
  • 5
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
    • V. Bolos, H. Peinado, M.A. Perez-Moreno, M.F. Fraga, M. Esteller, A. Cano The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors J Cell Sci 116 2003 499 511
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 7
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
    • P. Savagner Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition Bioessays 23 2001 912 923
    • (2001) Bioessays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 8
    • 0036333522 scopus 로고    scopus 로고
    • Overexpression of Snail family members highlights their ability to promote chick neural crest formation
    • M.G. del Barrio, M.A. Nieto Overexpression of Snail family members highlights their ability to promote chick neural crest formation Development 129 2002 1583 1593
    • (2002) Development , vol.129 , pp. 1583-1593
    • Del Barrio, M.G.1    Nieto, M.A.2
  • 9
    • 0028318730 scopus 로고
    • Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    • M.A. Nieto, M.G. Sargent, D.G. Wilkinson, J. Cooke Control of cell behavior during vertebrate development by Slug, a zinc finger gene Science 264 1994 835 839
    • (1994) Science , vol.264 , pp. 835-839
    • Nieto, M.A.1    Sargent, M.G.2    Wilkinson, D.G.3    Cooke, J.4
  • 10
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • M.A. Nieto The snail superfamily of zinc-finger transcription factors Nat Rev Mol Cell Biol 3 2002 155 166
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 11
    • 0035167812 scopus 로고    scopus 로고
    • The mouse snail gene encodes a key regulator of the epithelial- mesenchymal transition
    • E.A. Carver, R. Jiang, Y. Lan, K.F. Oram, T. Gridley The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition Mol Cell Biol 21 2001 8184 8188
    • (2001) Mol Cell Biol , vol.21 , pp. 8184-8188
    • Carver, E.A.1    Jiang, R.2    Lan, Y.3    Oram, K.F.4    Gridley, T.5
  • 13
  • 17
    • 27444440806 scopus 로고    scopus 로고
    • Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf
    • M. Kumasaka, S. Sato, I. Yajima, C.R. Goding, H. Yamamoto Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf Dev Dyn 234 2005 523 534
    • (2005) Dev Dyn , vol.234 , pp. 523-534
    • Kumasaka, M.1    Sato, S.2    Yajima, I.3    Goding, C.R.4    Yamamoto, H.5
  • 19
    • 0031901224 scopus 로고    scopus 로고
    • Neural crest induction in Xenopus: Evidence for a two-signal model
    • C. LaBonne, M. Bronner-Fraser Neural crest induction in Xenopus: evidence for a two-signal model Development 125 1998 2403 2414
    • (1998) Development , vol.125 , pp. 2403-2414
    • Labonne, C.1    Bronner-Fraser, M.2
  • 20
    • 34249289041 scopus 로고    scopus 로고
    • Snail Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • H. Peinado, D. Olmeda, A. Cano Snail Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7 2007 415 428
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 21
    • 0034680368 scopus 로고    scopus 로고
    • Snail/slug family of repressors: Slowly going into the fast lane of development and cancer
    • K. Hemavathy, S.I. Ashraf, Y.T. Ip Snail/slug family of repressors: slowly going into the fast lane of development and cancer Gene 257 2000 1 12
    • (2000) Gene , vol.257 , pp. 1-12
    • Hemavathy, K.1    Ashraf, S.I.2    Ip, Y.T.3
  • 24
    • 0035816677 scopus 로고    scopus 로고
    • Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail
    • I. Poser, D. Dominguez, A.G. de Herreros, A. Varnai, R. Buettner, A.K. Bosserhoff Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail J Biol Chem 276 2001 24661 24666
    • (2001) J Biol Chem , vol.276 , pp. 24661-24666
    • Poser, I.1    Dominguez, D.2    De Herreros, A.G.3    Varnai, A.4    Buettner, R.5    Bosserhoff, A.K.6
  • 26
    • 1642555931 scopus 로고    scopus 로고
    • Transcription factors involved in development and progression of malignant melanoma
    • I. Poser, A.K. Bosserhoff Transcription factors involved in development and progression of malignant melanoma Histol Histopathol 19 2004 173 188
    • (2004) Histol Histopathol , vol.19 , pp. 173-188
    • Poser, I.1    Bosserhoff, A.K.2
  • 28
    • 0037278743 scopus 로고    scopus 로고
    • Transcriptional regulation of metastasis-related genes in human melanoma
    • O. Nyormoi, M. Bar-Eli Transcriptional regulation of metastasis-related genes in human melanoma Clin Exp Metastasis 20 2003 251 263
    • (2003) Clin Exp Metastasis , vol.20 , pp. 251-263
    • Nyormoi, O.1    Bar-Eli, M.2
  • 30
    • 34447136179 scopus 로고    scopus 로고
    • Short interfering RNA directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustine
    • I. Vannini, M. Bonafe, A. Tesei, M. Rosetti, F. Fabbri, G. Storci, P. Ulivi, G. Brigliadori, D. Amadori, W. Zoli Short interfering RNA directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustine Cell Oncol 29 2007 279 287
    • (2007) Cell Oncol , vol.29 , pp. 279-287
    • Vannini, I.1    Bonafe, M.2    Tesei, A.3    Rosetti, M.4    Fabbri, F.5    Storci, G.6    Ulivi, P.7    Brigliadori, G.8    Amadori, D.9    Zoli, W.10
  • 31
    • 77949802161 scopus 로고    scopus 로고
    • Melanoma biomarker expression in melanocytic tumor progression: A tissue microarray study
    • R.M. Nazarian, V.G. Prieto, D.E. Elder, L.M. Duncan Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study J Cutan Pathol 37 Suppl 1 2010 41 47
    • (2010) J Cutan Pathol , vol.37 , Issue.SUPPL. 1 , pp. 41-47
    • Nazarian, R.M.1    Prieto, V.G.2    Elder, D.E.3    Duncan, L.M.4
  • 32
    • 33846813839 scopus 로고    scopus 로고
    • The role of the slug transcription factor in cell migration during corneal re-epithelialization in the dog
    • H.L. Chandler, C.M. Colitz, P. Lu, W.J. Saville, D.F. Kusewitt The role of the slug transcription factor in cell migration during corneal re-epithelialization in the dog Exp Eye Res 84 2007 400 411
    • (2007) Exp Eye Res , vol.84 , pp. 400-411
    • Chandler, H.L.1    Colitz, C.M.2    Lu, P.3    Saville, W.J.4    Kusewitt, D.F.5
  • 33
    • 0028131915 scopus 로고
    • Selective degradation of early-response-gene mRNAs: Functional analyses of sequence features of the AU-rich elements
    • C.Y. Chen, A.B. Shyu Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements Mol Cell Biol 14 1994 8471 8482
    • (1994) Mol Cell Biol , vol.14 , pp. 8471-8482
    • Chen, C.Y.1    Shyu, A.B.2
  • 37
    • 12944277027 scopus 로고    scopus 로고
    • Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
    • Y. Uchikado, S. Natsugoe, H. Okumura, T. Setoyama, M. Matsumoto, S. Ishigami, T. Aikou Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma Clin Cancer Res 11 2005 1174 1180
    • (2005) Clin Cancer Res , vol.11 , pp. 1174-1180
    • Uchikado, Y.1    Natsugoe, S.2    Okumura, H.3    Setoyama, T.4    Matsumoto, M.5    Ishigami, S.6    Aikou, T.7
  • 38
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • G. Giannelli, C. Bergamini, E. Fransvea, C. Sgarra, S. Antonaci Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma Gastroenterology 129 2005 1375 1383
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 40
    • 63849130585 scopus 로고    scopus 로고
    • Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers
    • C.C. Alves, F. Carneiro, H. Hoefler, K.F. Becker Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers Front Biosci 14 2009 3035 3050
    • (2009) Front Biosci , vol.14 , pp. 3035-3050
    • Alves, C.C.1    Carneiro, F.2    Hoefler, H.3    Becker, K.F.4
  • 41
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • K.M. Hajra, D.Y. Chen, E.R. Fearon The SLUG zinc-finger protein represses E-cadherin in breast cancer Cancer Res 62 2002 1613 1618
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 42
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • E.D. Hay An overview of epithelio-mesenchymal transformation Acta Anat (Basel) 154 1995 8 20
    • (1995) Acta Anat (Basel) , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 43
    • 16544383953 scopus 로고    scopus 로고
    • The role of altered cell-cell communication in melanoma progression
    • N.K. Haass, K.S. Smalley, M. Herlyn The role of altered cell-cell communication in melanoma progression J Mol Histol 35 2004 309 318
    • (2004) J Mol Histol , vol.35 , pp. 309-318
    • Haass, N.K.1    Smalley, K.S.2    Herlyn, M.3
  • 44
    • 0031005659 scopus 로고    scopus 로고
    • The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
    • P. Savagner, K.M. Yamada, J.P. Thiery The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition J Cell Biol 137 1997 1403 1419
    • (1997) J Cell Biol , vol.137 , pp. 1403-1419
    • Savagner, P.1    Yamada, K.M.2    Thiery, J.P.3
  • 47
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK
    • M. Conacci-Sorrell, I. Simcha, T. Ben-Yedidia, J. Blechman, P. Savagner, A. Ben-Ze'ev Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK J Cell Biol 163 2003 847 857
    • (2003) J Cell Biol , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blechman, J.4    Savagner, P.5    Ben-Ze'Ev, A.6
  • 48
    • 16244418364 scopus 로고    scopus 로고
    • A secreted form of P-cadherin is expressed in malignant melanoma
    • R. Bauer, R. Hein, A.K. Bosserhoff A secreted form of P-cadherin is expressed in malignant melanoma Exp Cell Res 305 2005 418 426
    • (2005) Exp Cell Res , vol.305 , pp. 418-426
    • Bauer, R.1    Hein, R.2    Bosserhoff, A.K.3
  • 49
    • 77955394992 scopus 로고    scopus 로고
    • A novel function for vimentin: The potential biomarker for predicting melanoma hematogenous metastasis
    • M. Li, B. Zhang, B. Sun, X. Wang, X. Ban, T. Sun, Z. Liu, X. Zhao A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis J Exp Clin Cancer Res 29 2010 109
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 109
    • Li, M.1    Zhang, B.2    Sun, B.3    Wang, X.4    Ban, X.5    Sun, T.6    Liu, Z.7    Zhao, X.8
  • 50
    • 80051797683 scopus 로고    scopus 로고
    • Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma
    • C. Wels, S. Joshi, P. Koefinger, H. Bergler, H. Schaider Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma J Invest Dermatol 131 2011 1877 1885
    • (2011) J Invest Dermatol , vol.131 , pp. 1877-1885
    • Wels, C.1    Joshi, S.2    Koefinger, P.3    Bergler, H.4    Schaider, H.5
  • 51
    • 34347252289 scopus 로고    scopus 로고
    • Up-regulation of MET expression by alpha-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis
    • L. Beuret, E. Flori, C. Denoyelle, K. Bille, R. Busca, M. Picardo, C. Bertolotto, R. Ballotti Up-regulation of MET expression by alpha-melanocyte- stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis J Biol Chem 282 2007 14140 14147
    • (2007) J Biol Chem , vol.282 , pp. 14140-14147
    • Beuret, L.1    Flori, E.2    Denoyelle, C.3    Bille, K.4    Busca, R.5    Picardo, M.6    Bertolotto, C.7    Ballotti, R.8
  • 52
  • 54
    • 63149194964 scopus 로고    scopus 로고
    • (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
    • C.A. Pratilas, B.S. Taylor, Q. Ye, A. Viale, C. Sander, D.B. Solit, N. Rosen (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway Proc Natl Acad Sci USA 106 2009 4519 4524
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4519-4524
    • Pratilas, C.A.1    Taylor, B.S.2    Ye, Q.3    Viale, A.4    Sander, C.5    Solit, D.B.6    Rosen, N.7
  • 60
    • 3042703943 scopus 로고    scopus 로고
    • The developmental transcription factor slug is widely expressed in tissues of adult mice
    • A.E. Parent, C. Choi, K. Caudy, T. Gridley, D.F. Kusewitt The developmental transcription factor slug is widely expressed in tissues of adult mice J Histochem Cytochem 52 2004 959 965
    • (2004) J Histochem Cytochem , vol.52 , pp. 959-965
    • Parent, A.E.1    Choi, C.2    Caudy, K.3    Gridley, T.4    Kusewitt, D.F.5
  • 61
    • 80052403945 scopus 로고    scopus 로고
    • The EMT regulator slug and lung carcinogenesis
    • J.Y. Shih, P.C. Yang The EMT regulator slug and lung carcinogenesis Carcinogenesis 32 2011 1299 1304
    • (2011) Carcinogenesis , vol.32 , pp. 1299-1304
    • Shih, J.Y.1    Yang, P.C.2
  • 64
    • 27744600102 scopus 로고    scopus 로고
    • Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas
    • A.P. Smith, K. Hoek, D. Becker Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas Cancer Biol Ther 4 2005 1018 1029
    • (2005) Cancer Biol Ther , vol.4 , pp. 1018-1029
    • Smith, A.P.1    Hoek, K.2    Becker, D.3
  • 65
    • 51749094162 scopus 로고    scopus 로고
    • From UVs to metastases: Modeling melanoma initiation and progression in the mouse
    • M.R. Zaidi, C.P. Day, G. Merlino From UVs to metastases: modeling melanoma initiation and progression in the mouse J Invest Dermatol 128 2008 2381 2391
    • (2008) J Invest Dermatol , vol.128 , pp. 2381-2391
    • Zaidi, M.R.1    Day, C.P.2    Merlino, G.3
  • 66
    • 21244437500 scopus 로고    scopus 로고
    • Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer
    • T.A. Martin, A. Goyal, G. Watkins, W.G. Jiang Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer Ann Surg Oncol 12 2005 488 496
    • (2005) Ann Surg Oncol , vol.12 , pp. 488-496
    • Martin, T.A.1    Goyal, A.2    Watkins, G.3    Jiang, W.G.4
  • 67
    • 33750987299 scopus 로고    scopus 로고
    • Expression of Snail Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
    • S. Sivertsen, R. Hadar, S. Elloul, L. Vintman, C. Bedrossian, R. Reich, B. Davidson Expression of Snail Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression Lung Cancer 54 2006 309 317
    • (2006) Lung Cancer , vol.54 , pp. 309-317
    • Sivertsen, S.1    Hadar, R.2    Elloul, S.3    Vintman, L.4    Bedrossian, C.5    Reich, R.6    Davidson, B.7
  • 68
    • 70350143237 scopus 로고    scopus 로고
    • Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells
    • M.J. Joseph, S. Dangi-Garimella, M.A. Shields, M.E. Diamond, L. Sun, J.E. Koblinski, H.G. Munshi Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells J Cell Biochem 108 2009 726 736
    • (2009) J Cell Biochem , vol.108 , pp. 726-736
    • Joseph, M.J.1    Dangi-Garimella, S.2    Shields, M.A.3    Diamond, M.E.4    Sun, L.5    Koblinski, J.E.6    Munshi, H.G.7
  • 69
    • 33745086313 scopus 로고    scopus 로고
    • Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
    • M. Shioiri, T. Shida, K. Koda, K. Oda, K. Seike, M. Nishimura, S. Takano, M. Miyazaki Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients Br J Cancer 94 2006 1816 1822
    • (2006) Br J Cancer , vol.94 , pp. 1816-1822
    • Shioiri, M.1    Shida, T.2    Koda, K.3    Oda, K.4    Seike, K.5    Nishimura, M.6    Takano, S.7    Miyazaki, M.8
  • 70
    • 0038456148 scopus 로고    scopus 로고
    • Function and regulation of melanoma-stromal fibroblast interactions: When seeds meet soil
    • G. Li, K. Satyamoorthy, F. Meier, C. Berking, T. Bogenrieder, M. Herlyn Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil Oncogene 22 2003 3162 3171
    • (2003) Oncogene , vol.22 , pp. 3162-3171
    • Li, G.1    Satyamoorthy, K.2    Meier, F.3    Berking, C.4    Bogenrieder, T.5    Herlyn, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.