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Volumn 17, Issue 5, 2012, Pages 694-707

Proteasome inhibition and combination therapy for non-Hodgkin's lymphoma: From bench to bedside

Author keywords

Bortezomib; Carfilzomib; Lymphoma; Marizomib; Non Hodgkin's; ONX 0912

Indexed keywords

BENDAMUSTINE; BORTEZOMIB; CARFILZOMIB; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; GEMCITABINE; IBRITUMOMAB TIUXETAN; IXAZOMIB CITRATE; LENALIDOMIDE; METHOTREXATE; OBATOCLAX; OPROZOMIB; PREDNISONE; PROTEASOME INHIBITOR; RITUXIMAB; SALINOSPORAMIDE A; VINCRISTINE;

EID: 84861602611     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2011-0341     Document Type: Article
Times cited : (31)

References (163)
  • 1
    • 84861589188 scopus 로고    scopus 로고
    • Cancer Facts & Figures 2008
    • American Cancer Society
    • American Cancer Society. Cancer Facts & Figures 2008. Atlanta: American Cancer Society, 2012: 1-64.
    • (2012) Atlanta: American Cancer Society , pp. 1-64
  • 2
    • 79952945610 scopus 로고    scopus 로고
    • National Cancer Institute, Bethesda, MD: National Cancer Institute, accessed April 16, 2012
    • National Cancer Institute. SEER Stat Fact Sheets-Non-Hodgkin Lymphoma. Bethesda, MD: National Cancer Institute, seer.cancer.gov/statfacts/html/nhl. html, accessed April 16, 2012.
    • SEER Stat Fact Sheets-Non-Hodgkin Lymphoma
  • 3
    • 23244462775 scopus 로고    scopus 로고
    • Non-Hodgkin lymphoma: Diagnosis and treatment
    • Ansell SM, Armitage J. Non-Hodgkin lymphoma: Diagnosis and treatment. Mayo Clin Proc 2005;80: 1087-1097.
    • (2005) Mayo Clin Proc , vol.80 , pp. 1087-1097
    • Ansell, S.M.1    Armitage, J.2
  • 4
    • 30144443996 scopus 로고    scopus 로고
    • Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
    • Morton LM, Wang SS, Devesa SS et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood 2006;107:265-276.
    • (2006) Blood , vol.107 , pp. 265-276
    • Morton, L.M.1    Wang, S.S.2    Devesa, S.S.3
  • 5
    • 35748958102 scopus 로고    scopus 로고
    • Expanding therapeutic options in mantle cell lymphoma
    • Goy A, Feldman T. Expanding therapeutic options in mantle cell lymphoma. Clin Lymphoma Myeloma 2007;7(suppl 5):S 184-5191.
    • (2007) Clin Lymphoma Myeloma , vol.7 , Issue.SUPPL. 5 , pp. 184-5191
    • Goy, A.1    Feldman, T.2
  • 6
    • 67649653923 scopus 로고    scopus 로고
    • Treatment strategies for relapsed and refractory aggressive non-Hodgkin's lymphoma
    • Prichard M, Harris T, Williams ME et al. Treatment strategies for relapsed and refractory aggressive non-Hodgkin's lymphoma. Expert Opin Pharmacother 2009; 10:983-995.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 983-995
    • Prichard, M.1    Harris, T.2    Williams, M.E.3
  • 7
    • 75349111310 scopus 로고    scopus 로고
    • Radioimmunotherapy for stem cell transplantation in non-Hodgkin's lymphoma: In pursuit of a complete response
    • Gisselbrecht C, Vose J, Nademanee A et al. Radioimmunotherapy for stem cell transplantation in non-Hodgkin's lymphoma: In pursuit of a complete response. The Oncologist 2009;14(suppl 2):41-51.
    • (2009) The Oncologist , vol.14 , Issue.SUPPL. 2 , pp. 41-51
    • Gisselbrecht, C.1    Vose, J.2    Nademanee, A.3
  • 8
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: A suitable antineoplastic target. Nat Rev Cancer 2004;4:349-360.
    • (2004) Nat Rev Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 9
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NF-κ B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham LV, Tamayo AT, Yoshimura LC et al. Inhibition of constitutive NF-κ B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol 2003;171:88-95.
    • (2003) J Immunol , vol.171 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3
  • 10
    • 34047257880 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines
    • Strauss SJ, Higginbottom K, JÏiger S et al. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines. Cancer Res 2007; 67:2783-2790.
    • (2007) Cancer Res , vol.67 , pp. 2783-2790
    • Strauss, S.J.1    Higginbottom, K.2    Jïiger, S.3
  • 11
    • 24644517593 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells
    • Matta H, Chaudhary PM. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther 2005;4:77-82.
    • (2005) Cancer Biol Ther , vol.4 , pp. 77-82
    • Matta, H.1    Chaudhary, P.M.2
  • 12
    • 4344643781 scopus 로고    scopus 로고
    • Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro
    • Satou Y, Nosaka K, Koya Y et al. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 2004;18:1357-1363.
    • (2004) Leukemia , vol.18 , pp. 1357-1363
    • Satou, Y.1    Nosaka, K.2    Koya, Y.3
  • 13
    • 19944434172 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma
    • Nasr R, El-Sabban ME, Karam JA et al. Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Oncogene 2005;24:419-430.
    • (2005) Oncogene , vol.24 , pp. 419-430
    • Nasr, R.1    El-Sabban, M.E.2    Karam, J.A.3
  • 14
    • 34347400984 scopus 로고    scopus 로고
    • Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: An in vitro and in vivo preclinical evaluation
    • Shen L, Au WY, Guo T et al. Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)-cell leukemia and lymphoma: An in vitro and in vivo preclinical evaluation. Blood 2007;110:469-470.
    • (2007) Blood , vol.110 , pp. 469-470
    • Shen, L.1    Au, W.Y.2    Guo, T.3
  • 15
    • 33947356281 scopus 로고    scopus 로고
    • Bortezomibmediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma
    • Bonvini P, Zorzi E, Basso G et al. Bortezomibmediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 2007;21:838-842.
    • (2007) Leukemia , vol.21 , pp. 838-842
    • Bonvini, P.1    Zorzi, E.2    Basso, G.3
  • 16
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • Perez-Galàn P, Roué G, Villamor N et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006;107: 257-264.
    • (2006) Blood , vol.107 , pp. 257-264
    • Perez-Galàn, P.1    Roué, G.2    Villamor, N.3
  • 17
    • 33745810978 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells
    • Kabore AF, Sun J, Hu X et al. The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells. Apoptosis 2006;11:1175-1193.
    • (2006) Apoptosis , vol.11 , pp. 1175-1193
    • Kabore, A.F.1    Sun, J.2    Hu, X.3
  • 18
    • 42049110004 scopus 로고    scopus 로고
    • Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-KB pathways
    • Rizzatti EG, Mora-Jensen H, Weniger MA et al. Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-KB pathways. Leuk Lymphoma 2008;49:798-808.
    • (2008) Leuk Lymphoma , vol.49 , pp. 798-808
    • Rizzatti, E.G.1    Mora-Jensen, H.2    Weniger, M.A.3
  • 19
    • 33748682930 scopus 로고    scopus 로고
    • Cyclin Dl overexpression and response to bortezomib treatment in a breast cancer model
    • Ishii Y, Pirkmaier A, Alvarez JV et al. Cyclin Dl overexpression and response to bortezomib treatment in a breast cancer model. J Natl Cancer Inst 2006;98:1238-1247.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1238-1247
    • Ishii, Y.1    Pirkmaier, A.2    Alvarez, J.V.3
  • 20
    • 33646749892 scopus 로고    scopus 로고
    • The combination of the proteasome inhibitor bortezomib and the Bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide
    • O'Connor OA, Smith EA, Toner LE et al. The combination of the proteasome inhibitor bortezomib and the Bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide. Clin Cancer Res 2006;12:2902-2911.
    • (2006) Clin Cancer Res , vol.12 , pp. 2902-2911
    • O'Connor, O.A.1    Smith, E.A.2    Toner, L.E.3
  • 21
    • 79551503105 scopus 로고    scopus 로고
    • Radiosensitizing properties of bortezomib depend on therapeutic schedule
    • Labussière M, Pinel S, Vandamme M et al. Radiosensitizing properties of bortezomib depend on therapeutic schedule. Int J Radiat Oncol Biol Phys 2011;79: 892-900.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 892-900
    • Labussière, M.1    Pinel, S.2    Vandamme, M.3
  • 22
    • 56549108276 scopus 로고    scopus 로고
    • Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor Velcade (bortezomib, PS-341)
    • Kamer S, Ren Q, Dicker AP. Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor Velcade (bortezomib, PS-341). Arch Gynecol Obstet 2009;279:41-46.
    • (2009) Arch Gynecol Obstet , vol.279 , pp. 41-46
    • Kamer, S.1    Ren, Q.2    Dicker, A.P.3
  • 23
    • 34948881265 scopus 로고    scopus 로고
    • Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through downmodulation of NF-KB regulated gene products
    • Ahn KS, Sethi G, Chao TH et al. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through downmodulation of NF-KB regulated gene products. Blood 2007;110:2286-2295.
    • (2007) Blood , vol.110 , pp. 2286-2295
    • Ahn, K.S.1    Sethi, G.2    Chao, T.H.3
  • 24
    • 72549116835 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M et al. A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res 2009;15:7085-7091.
    • (2009) Clin Cancer Res , vol.15 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 25
    • 33748300908 scopus 로고    scopus 로고
    • The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
    • Ruiz S, Krupnik Y, Keating M et al. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Mol Cancer Ther 2006;5:1836-1843.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1836-1843
    • Ruiz, S.1    Krupnik, Y.2    Keating, M.3
  • 26
    • 77953264178 scopus 로고    scopus 로고
    • Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Aujay M et al. Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia. Blood 2010;115:4051-4060.
    • (2010) Blood , vol.115 , pp. 4051-4060
    • Roccaro, A.M.1    Sacco, A.2    Aujay, M.3
  • 27
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res 2010;70:1970-1980.
    • (2010) Cancer Res , vol.70 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 28
    • 33750209537 scopus 로고    scopus 로고
    • A novel proteasome inhibitor NPI-0052 as an anticancer therapy
    • Chauhan D, Hideshima T, Anderson KC. A novel proteasome inhibitor NPI-0052 as an anticancer therapy. Br J Cancer 2006;95:961-965.
    • (2006) Br J Cancer , vol.95 , pp. 961-965
    • Chauhan, D.1    Hideshima, T.2    Anderson, K.C.3
  • 29
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn DJ, Chen Q, Voorhees PM et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007;110:3281-3290.
    • (2007) Blood , vol.110 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 30
    • 33846253586 scopus 로고    scopus 로고
    • Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
    • Williamson MJ, Blank JL, Bruzzese FJ et al. Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib. Mol Cancer Ther 2006;5:3052-3061.
    • (2006) Mol Cancer Ther , vol.5
    • Williamson, M.J.1    Blank, J.L.2    Bruzzese, F.J.3
  • 31
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
    • Chauhan D, Catley L, Li G et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 2005;8:407-419.
    • (2005) Cancer Cell , vol.8 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 32
    • 34347375499 scopus 로고    scopus 로고
    • NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROSdependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
    • Miller CP, Ban K, Dujka ME et al. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROSdependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 2007;110: 267-277.
    • (2007) Blood , vol.110 , pp. 267-277
    • Miller, C.P.1    Ban, K.2    Dujka, M.E.3
  • 33
    • 79951684725 scopus 로고    scopus 로고
    • Marizomib, a proteasome inhibitor for all seasons: Preclinical profile and a framework for clinical trials
    • Potts BC, Albitar MX, Anderson KC et al. Marizomib, a proteasome inhibitor for all seasons: Preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets 2011;11:254-284.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 254-284
    • Potts, B.C.1    Albitar, M.X.2    Anderson, K.C.3
  • 34
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: Second-generation proteasome inhibitors as anti cancer therapy
    • Dick LR, Fleming PE. Building on bortezomib: Second-generation proteasome inhibitors as anti cancer therapy. Drug Discov Today 2010;15:243-249.
    • (2010) Drug Discov Today , vol.15 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 35
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 2010;116:4906-4915.
    • (2010) Blood , vol.116 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 36
    • 77954343931 scopus 로고    scopus 로고
    • Newly diagnosed and relapsed follicular lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • ESMO Guidelines Working Group
    • Dreyling M. ESMO Guidelines Working Group. Newly diagnosed and relapsed follicular lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(suppl5):vl81-v183.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Dreyling, M.1
  • 37
    • 77954356939 scopus 로고    scopus 로고
    • Diffuse large B-cell non-Hodgkin's lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • ESMO Guidelines Working Group
    • Tilly H, Dreyling M. ESMO Guidelines Working Group. Diffuse large B-cell non-Hodgkin's lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(suppl5):v172-v174.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Tilly, H.1    Dreyling, M.2
  • 38
    • 33847297956 scopus 로고    scopus 로고
    • Sequence-dependent synergy of the proteasome inhibitor bortezomib and cytarabine in mantle cell lymphoma
    • Weigert O, Pastore A, Rieken M et al. Sequence-dependent synergy of the proteasome inhibitor bortezomib and cytarabine in mantle cell lymphoma. Leukemia 2007;21:524-528.
    • (2007) Leukemia , vol.21 , pp. 524-528
    • Weigert, O.1    Pastore, A.2    Rieken, M.3
  • 39
    • 77955733961 scopus 로고    scopus 로고
    • Cell based assays completed with the mantle cell lymphoma cell lines Z138 and NCEB-1 indicate that combinations of bortezomib and flavopiridol interact to achieve synergistic activity [abstract]
    • Abstract
    • Kapanen A, Tucker C, Chikh G et al. Cell based assays completed with the mantle cell lymphoma cell lines Z138 and NCEB-1 indicate that combinations of bortezomib and flavopiridol interact to achieve synergistic activity [abstract]. Blood 2005;106:Abstract 2410.
    • (2005) Blood , vol.106
    • Kapanen, A.1    Tucker, C.2    Chikh, G.3
  • 40
    • 84872757749 scopus 로고    scopus 로고
    • Combination bortezomib (PS341, Velcade) and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma [abstract]
    • Abstract
    • Wadehra N, Lin T, Ryan T et al. Combination bortezomib (PS341, Velcade) and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma [abstract]. Blood 2005;106:Abstract 2407.
    • (2005) Blood , vol.106
    • Wadehra, N.1    Lin, T.2    Ryan, T.3
  • 41
    • 38349053780 scopus 로고    scopus 로고
    • Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo
    • Wang M, Han XH, Zhang L et al. Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leukemia 2008;22:179-185.
    • (2008) Leukemia , vol.22 , pp. 179-185
    • Wang, M.1    Han, X.H.2    Zhang, L.3
  • 42
    • 77953665404 scopus 로고    scopus 로고
    • Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma
    • Alinari L, White VL, Earl CT et al. Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma. MAbs 2009;1:31-40.
    • (2009) MAbs , vol.1 , pp. 31-40
    • Alinari, L.1    White, V.L.2    Earl, C.T.3
  • 43
    • 33746387050 scopus 로고    scopus 로고
    • Combined targeting of the proteasome and Bcl-2 sensitizes human B-cell lymphoma and multiple myeloma to cyclophosphamide in in vitro and in vivo models of these diseases [abstract]
    • Abstract 2484
    • O' Connor O, Toner L, Smith E et al. Combined targeting of the proteasome and Bcl-2 sensitizes human B-cell lymphoma and multiple myeloma to cyclophosphamide in in vitro and in vivo models of these diseases [abstract]. Blood 2004;104:Abstract 2484.
    • (2004) Blood , vol.104
    • O' Connor, O.1    Toner, L.2    Smith, E.3
  • 44
    • 79953664907 scopus 로고    scopus 로고
    • Inhibition of the Pan-Bcl-2 family by the small molecule GX15-070 induces apoptosis in mantle cell lymphoma (MCL) cells and enhances the activity of two proteasome inhibitors (NPI-0052 and bortezomib), and doxorubicin chemotherapy [abstract]
    • Abstract 2532
    • Yazbeck VY, Georgakis GV, Li Y et al. Inhibition of the Pan-Bcl-2 family by the small molecule GX15-070 induces apoptosis in mantle cell lymphoma (MCL) cells and enhances the activity of two proteasome inhibitors (NPI-0052 and bortezomib), and doxorubicin chemotherapy [abstract]. Blood 2006;108:Abstract 2532.
    • (2006) Blood , vol.108
    • Yazbeck, V.Y.1    Georgakis, G.V.2    Li, Y.3
  • 45
    • 84872749478 scopus 로고    scopus 로고
    • Obatoclax (GX15-070) is a potent antagonist of constitutive Mcl1/Bak interactions in intact mitochondrial membrane and synergizes with bortezomib in mantle cell lymphoma [abstract]
    • Abstract
    • Shore G, Watson M, Roulston A et al. Obatoclax (GX15-070) is a potent antagonist of constitutive Mcl1/Bak interactions in intact mitochondrial membrane and synergizes with bortezomib in mantle cell lymphoma [abstract]. Blood 2006;108:Abstract 832.
    • (2006) Blood , vol.108
    • Shore, G.1    Watson, M.2    Roulston, A.3
  • 46
    • 67649411349 scopus 로고    scopus 로고
    • GX15-070 and bortezomib induce up-regulation of BH3 single domain pro-apoptotic proteins Puma and Noxa and is associated with synergistic anti-tumor activity in rituximab-sensitive, rituximab-resistant cell lines (RSCL and RRCL), and primary lymphoma patient specimens [abstract]
    • Abstract 1389
    • Gruber EA, Czuczman MS, Olejniczak SH et al. GX15-070 and bortezomib induce up-regulation of BH3 single domain pro-apoptotic proteins Puma and Noxa and is associated with synergistic anti-tumor activity in rituximab-sensitive, rituximab-resistant cell lines (RSCL and RRCL), and primary lymphoma patient specimens [abstract]. Blood 2007;110:Abstract 1389.
    • (2007) Blood , vol.110
    • Gruber, E.A.1    Czuczman, M.S.2    Olejniczak, S.H.3
  • 47
    • 34248362003 scopus 로고    scopus 로고
    • The BH3mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    • Perez-Galàn P, Roué G, Villamor N et al. The BH3mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood 2007;109:4441-4449.
    • (2007) Blood , vol.109 , pp. 4441-4449
    • Perez-Galàn, P.1    Roué, G.2    Villamor, N.3
  • 48
    • 51649115498 scopus 로고    scopus 로고
    • BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells
    • Perez-Galàn P, Roué G, Lopez-Guerra M et al. BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. Leukemia 2008;22:1712-1720.
    • (2008) Leukemia , vol.22 , pp. 1712-1720
    • Perez-Galàn, P.1    Roué, G.2    Lopez-Guerra, M.3
  • 49
    • 53049106757 scopus 로고    scopus 로고
    • The BH3-only mimetic ABT-737 synergizes the anti-neoplastic activity of proteasome inhibitors in lymphoid malignancies
    • Paoluzzi L, Gonen M, Bhagat G et al. The BH3-only mimetic ABT-737 synergizes the anti-neoplastic activity of proteasome inhibitors in lymphoid malignancies. Blood 2008;112:2906-2916.
    • (2008) Blood , vol.112 , pp. 2906-2916
    • Paoluzzi, L.1    Gonen, M.2    Bhagat, G.3
  • 50
    • 84894115513 scopus 로고    scopus 로고
    • BCL6 inhibitor peptide have powerful anti-lymphoma activity in animal models of diffuse large B-cell lymphoma and synergize with other anti-lymphoma drugs [abstract]
    • Abstract 827
    • Antun A, Cerchietti L, Aparo S et al. BCL6 inhibitor peptide have powerful anti-lymphoma activity in animal models of diffuse large B-cell lymphoma and synergize with other anti-lymphoma drugs [abstract]. Blood 2006;108:Abstract 827.
    • (2006) Blood , vol.108
    • Antun, A.1    Cerchietti, L.2    Aparo, S.3
  • 51
    • 77956225330 scopus 로고    scopus 로고
    • The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
    • Ackler S, Mitten MJ, Foster K et al. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother Pharmacol 2010;66:869-880.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 869-880
    • Ackler, S.1    Mitten, M.J.2    Foster, K.3
  • 52
    • 0242468166 scopus 로고    scopus 로고
    • Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclindependent kinase inhibitor flavopiridol through a SAPK/ JNK- and NF-KB-dependent process
    • Dai Y, Rahmani M, Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclindependent kinase inhibitor flavopiridol through a SAPK/ JNK- and NF-KB-dependent process. Oncogene 2003; 22:7108-7122.
    • (2003) Oncogene , vol.22 , pp. 7108-7122
    • Dai, Y.1    Rahmani, M.2    Grant, S.3
  • 53
    • 84872749358 scopus 로고    scopus 로고
    • Rapamycin enhances the cytotoxicity of bortezomib and rituximab on mantle cell lymphoma (MCL) cell lines [abstract]
    • Abstract 2411
    • Ismail LK, Timm M, Novak A et al. Rapamycin enhances the cytotoxicity of bortezomib and rituximab on mantle cell lymphoma (MCL) cell lines [abstract]. Blood 2005;106:Abstract 2411.
    • (2005) Blood , vol.106
    • Ismail, L.K.1    Timm, M.2    Novak, A.3
  • 54
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians T, Mori A, O' Kelly J et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 2007;21:333-339.
    • (2007) Leukemia , vol.21 , pp. 333-339
    • Haritunians, T.1    Mori, A.2    O' Kelly, J.3
  • 55
    • 84872748897 scopus 로고    scopus 로고
    • The novel HDAC inhibitor UCL67022 is highly potent in multiple myeloma and non-Hodgkin's lymphoma and is enhanced by bortezomib [abstract]
    • Abstract 2604
    • Maharaj L, Popat R, Chahwan A et al. The novel HDAC inhibitor UCL67022 is highly potent in multiple myeloma and non-Hodgkin's lymphoma and is enhanced by bortezomib [abstract]. Blood 2006;108:Abstract 2604.
    • (2006) Blood , vol.108
    • Maharaj, L.1    Popat, R.2    Chahwan, A.3
  • 56
    • 84859817215 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor (HDACi) PCI-24781 and bortezomib result in synergistic apoptosis in Hodgkin lymphoma (HL) and non-Hodgkin's lymphoma (NHL) cell lines: Investigation of cell death and NFKB-mediated pathways [abstract]
    • Abstract 3589
    • Bhalla S, David K, Mauro L et al. Histone deacetylase inhibitor (HDACi) PCI-24781 and bortezomib result in synergistic apoptosis in Hodgkin lymphoma (HL) and non-Hodgkin's lymphoma (NHL) cell lines: Investigation of cell death and NFKB-mediated pathways [abstract]. Blood 2007;110:Abstract 3589.
    • (2007) Blood , vol.110
    • Bhalla, S.1    David, K.2    Mauro, L.3
  • 57
    • 38049126172 scopus 로고    scopus 로고
    • Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma
    • Heider U, von Metzler I, Kaiser M et al., Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma. Eur J Haematol 2008;80:133-142.
    • (2008) Eur J Haematol , vol.80 , pp. 133-142
    • Heider, U.1    von Metzler, I.2    Kaiser, M.3
  • 58
    • 84872749931 scopus 로고    scopus 로고
    • Targeting histone deacetylases and unfolded protein mediated endoplasmic reticulum (ER) stress as a strategy against human mantle cell lymphoma [abstract]
    • Abstract 1378
    • Rao R, Fiskus W, Joshi R et al. Targeting histone deacetylases and unfolded protein mediated endoplasmic reticulum (ER) stress as a strategy against human mantle cell lymphoma [abstract]. Blood 2007;110: Abstract 1378.
    • (2007) Blood , vol.110
    • Rao, R.1    Fiskus, W.2    Joshi, R.3
  • 59
    • 74549173443 scopus 로고    scopus 로고
    • Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma
    • Paoluzzi L, Scotto L, Marchi E et al. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Clin Cancer Res 2010; 16:554-565.
    • (2010) Clin Cancer Res , vol.16 , pp. 554-565
    • Paoluzzi, L.1    Scotto, L.2    Marchi, E.3
  • 60
    • 84872757939 scopus 로고    scopus 로고
    • Panobinostat, a novel histone deacetylase (HiDAC) inhibitor enhances the anti-tumor activity of bortezomib (BTZ) in rituximab-chemotherapy sensitive and resistant lymphoma cell lines [abstract]
    • Abstract 3936
    • Hernandez-Ilizaliturri FJ, Mavis C, Maraj I et al. Panobinostat, a novel histone deacetylase (HiDAC) inhibitor enhances the anti-tumor activity of bortezomib (BTZ) in rituximab-chemotherapy sensitive and resistant lymphoma cell lines [abstract]. Blood 2010;116: Abstract 3936.
    • (2010) Blood , vol.116
    • Hernandez-Ilizaliturri, F.J.1    Mavis, C.2    Maraj, I.3
  • 61
    • 79960487350 scopus 로고    scopus 로고
    • Treatment with histone deacetylase 6-specific inhibitor WT-161 disrupts hsp90 function, abrogates aggresome formation and sensitizes human mantle cell lymphoma cells to lethal ER stress induced by proteasome inhibitor carfilzomib [abstract]
    • Abstract 2856
    • Rao R, Fiskus W, Balusu R et al. Treatment with histone deacetylase 6-specific inhibitor WT-161 disrupts hsp90 function, abrogates aggresome formation and sensitizes human mantle cell lymphoma cells to lethal ER stress induced by proteasome inhibitor carfilzomib [abstract]. Blood 2010;116:Abstract 2856.
    • (2010) Blood , vol.116
    • Rao, R.1    Fiskus, W.2    Balusu, R.3
  • 62
    • 79956064483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo [abstract]
    • Abstract 3938
    • Dasmahapatra G, Lembersky D, Friedberg JW et al. Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo [abstract]. Blood 2010;116:Abstract 3938.
    • (2010) Blood , vol.116
    • Dasmahapatra, G.1    Lembersky, D.2    Friedberg, J.W.3
  • 63
    • 74549202247 scopus 로고    scopus 로고
    • The antihistaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor
    • Paoluzzi L, Scotto L, Marchi E et al. The antihistaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor. Br J Haematol 2009;146:656-659.
    • (2009) Br J Haematol , vol.146 , pp. 656-659
    • Paoluzzi, L.1    Scotto, L.2    Marchi, E.3
  • 64
    • 77957584063 scopus 로고    scopus 로고
    • Role of CAAT/ enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells
    • Rao R, Nalluri S, Fiskus W et al. Role of CAAT/ enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells. Clin Cancer Res 2010;16:4742-4754.
    • (2010) Clin Cancer Res , vol.16 , pp. 4742-4754
    • Rao, R.1    Nalluri, S.2    Fiskus, W.3
  • 65
    • 84872748166 scopus 로고    scopus 로고
    • The proteasome inhibitor NPI-0052 in combination with bortezomib induces antitumor activity in Waldenstrom macroglobulinemia [abstract]
    • Abstract 4746
    • Jia X, Leleu X, Moreau AS et al. The proteasome inhibitor NPI-0052 in combination with bortezomib induces antitumor activity in Waldenstrom macroglobulinemia [abstract]. Blood 2006;108:Abstract 4746.
    • (2006) Blood , vol.108
    • Jia, X.1    Leleu, X.2    Moreau, A.S.3
  • 66
    • 84872757516 scopus 로고    scopus 로고
    • The combination of bortezomib and NPI-0052 exerts anti-tumor activity in Waldenstrom macroglobulinemia (WM) [abstract]
    • Abstract 1516
    • Roccaro A, Leleu X, Sacco A et al. The combination of bortezomib and NPI-0052 exerts anti-tumor activity in Waldenstrom macroglobulinemia (WM) [abstract]. Blood 2007;110:Abstract 1516.
    • (2007) Blood , vol.110
    • Roccaro, A.1    Leleu, X.2    Sacco, A.3
  • 67
    • 34250016979 scopus 로고    scopus 로고
    • Novel agent perifosine enhances antitumor activity of bortezomib, rituximab and other conventional therapies in Waldenstrom's macroglobulinemia [abstract]
    • Abstract 2517
    • Leleu X, O'Sullivan G, Jia X et al. Novel agent perifosine enhances antitumor activity of bortezomib, rituximab and other conventional therapies in Waldenstrom's macroglobulinemia [abstract]. Blood 2006;108: Abstract 2517.
    • (2006) Blood , vol.108
    • Leleu, X.1    O'Sullivan, G.2    Jia, X.3
  • 68
    • 34347395015 scopus 로고    scopus 로고
    • The selective protein kinase CB inhibitor, enzastaurin, induces in vitro and in vivo antitumor activity in Waldenstrom's macroglobulinemia [abstract]
    • Abstract 2496
    • Moreau AS, Jia X, O'Sullivan G et al. The selective protein kinase CB inhibitor, enzastaurin, induces in vitro and in vivo antitumor activity in Waldenstrom's macroglobulinemia [abstract]. Blood 2006;108:Abstract 2496.
    • (2006) Blood , vol.108
    • Moreau, A.S.1    Jia, X.2    O'Sullivan, G.3
  • 69
    • 77954605430 scopus 로고    scopus 로고
    • Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: Therapeutic implications
    • Pham LV, Tamayo AT, Li C et al. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: Therapeutic implications. Mol Cancer Ther 2010;9:2026-2036.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2026-2036
    • Pham, L.V.1    Tamayo, A.T.2    Li, C.3
  • 70
    • 79251545172 scopus 로고    scopus 로고
    • The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78
    • Roué G, Perez-Galàn P, Mozos A et al. The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78. Blood 2011;117:1270-1279.
    • (2011) Blood , vol.117 , pp. 1270-1279
    • Roué, G.1    Perez-Galàn, P.2    Mozos, A.3
  • 71
    • 38749115417 scopus 로고    scopus 로고
    • Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits
    • Busse A, Kraus M, Na IK et al. Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits. Cancer 2008;112:659-670.
    • (2008) Cancer , vol.112 , pp. 659-670
    • Busse, A.1    Kraus, M.2    Na, I.K.3
  • 72
    • 33749236780 scopus 로고    scopus 로고
    • Active combination therapy of bortezomib (Velcade) and ibritumomab tiuxetan (Zevalin) in an in vivo diffuse large B-cell lymphoma model [abstract]
    • Abstract 2406
    • Pervan M, Calimlim J, Matso D et al. Active combination therapy of bortezomib (Velcade) and ibritumomab tiuxetan (Zevalin) in an in vivo diffuse large B-cell lymphoma model [abstract]. Blood 2005;106: Abstract 2406.
    • (2005) Blood , vol.106
    • Pervan, M.1    Calimlim, J.2    Matso, D.3
  • 73
    • 33846476267 scopus 로고    scopus 로고
    • Selective inhibition of IκB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
    • Roué G, Perez-Galàn P, Lopez-Guerra M et al. Selective inhibition of IκB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. J Immunol 2007;178:1923-1930.
    • (2007) J Immunol , vol.178 , pp. 1923-1930
    • Roué, G.1    Perez-Galàn, P.2    Lopez-Guerra, M.3
  • 74
    • 24944458177 scopus 로고    scopus 로고
    • Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    • Georgakis GV, Li Y, Humphreys R et al. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Br J Haematol 2005;130: 501-510.
    • (2005) Br J Haematol , vol.130 , pp. 501-510
    • Georgakis, G.V.1    Li, Y.2    Humphreys, R.3
  • 75
    • 34848912052 scopus 로고    scopus 로고
    • Bortezomib sensitizes non-Hodgkin's lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosisinducing ligand (TRAIL) receptors TRAIL-R1 and TRAIL-R2
    • Smith MR, Jin F, Joshi I. Bortezomib sensitizes non-Hodgkin's lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosisinducing ligand (TRAIL) receptors TRAIL-R1 and TRAIL-R2. Clin Cancer Res 2007;13:5528s-5534s.
    • (2007) Clin Cancer Res , vol.13
    • Smith, M.R.1    Jin, F.2    Joshi, I.3
  • 76
    • 77954334194 scopus 로고    scopus 로고
    • Ten-year follow-up after intense chemoimmunotherapy with rituximab-hyperCVAD alternating with rituximab-high dose methotrexate/cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma
    • Romaguera JE, Fayad LE, Feng L et al. Ten-year follow-up after intense chemoimmunotherapy with rituximab-hyperCVAD alternating with rituximab-high dose methotrexate/cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma. Br J Haematol 2010;150:200-208.
    • (2010) Br J Haematol , vol.150 , pp. 200-208
    • Romaguera, J.E.1    Fayad, L.E.2    Feng, L.3
  • 77
    • 38349097302 scopus 로고    scopus 로고
    • A phase II clinical trial of intensive chemotherapy followed by consolidative stem cell transplant: Long-term follow-up in newly diagnosed mantle cell lymphoma
    • Evens AM, Winter JN, Hou N et al. A phase II clinical trial of intensive chemotherapy followed by consolidative stem cell transplant: Long-term follow-up in newly diagnosed mantle cell lymphoma. Br J Haematol 2008;140:385-393.
    • (2008) Br J Haematol , vol.140 , pp. 385-393
    • Evens, A.M.1    Winter, J.N.2    Hou, N.3
  • 78
    • 53449089095 scopus 로고    scopus 로고
    • Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivopurged stem cell rescue: A nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group
    • Geisler CH, Kolstad A, Laurell A et al. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivopurged stem cell rescue: A nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 2008;112:2687-2693.
    • (2008) Blood , vol.112 , pp. 2687-2693
    • Geisler, C.H.1    Kolstad, A.2    Laurell, A.3
  • 79
    • 20144376591 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)
    • Lenz G, Dreyling M, Hoster E et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol 2005;23:1984-1992.
    • (2005) J Clin Oncol , vol.23 , pp. 1984-1992
    • Lenz, G.1    Dreyling, M.2    Hoster, E.3
  • 80
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J Clin Oncol 2008;26: 4473-4479.
    • (2008) J Clin Oncol , vol.26 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    van der Jagt, R.H.3
  • 81
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma
    • Rummel MJ, Al-Batran SE, Kim SZ et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma. J Clin Oncol 2005;23: 3383-3389.
    • (2005) J Clin Oncol , vol.23 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.E.2    Kim, S.Z.3
  • 82
    • 1842555344 scopus 로고    scopus 로고
    • RituximabEPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: Results of a phase II study
    • Jermann M, Jost LM, Taverna C et al. RituximabEPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: Results of a phase II study. Ann Oncol 2004;15:511-516.
    • (2004) Ann Oncol , vol.15 , pp. 511-516
    • Jermann, M.1    Jost, L.M.2    Taverna, C.3
  • 83
    • 75349085058 scopus 로고    scopus 로고
    • Rationale for consolidation to improve progression-free survival in patients with non-Hodgkin's lymphoma: A review of the evidence
    • Morschhauser F, Dreyling M, Rohatiner A et al. Rationale for consolidation to improve progression-free survival in patients with non-Hodgkin's lymphoma: A review of the evidence. The Oncologist 2009;14(suppl 2):17-29.
    • (2009) The Oncologist , vol.14 , Issue.SUPPL. 2 , pp. 17-29
    • Morschhauser, F.1    Dreyling, M.2    Rohatiner, A.3
  • 84
    • 0036659907 scopus 로고    scopus 로고
    • Rituximab (anti-CD20 monoclonal antibody) as consolidation of first-line CHOP chemotherapy in patients with follicular lymphoma: A phase II study
    • Jaeger G, Neumeister P, Brezinschek R et al. Rituximab (anti-CD20 monoclonal antibody) as consolidation of first-line CHOP chemotherapy in patients with follicular lymphoma: A phase II study. Eur J Haematol 2002; 69:21-26.
    • (2002) Eur J Haematol , vol.69 , pp. 21-26
    • Jaeger, G.1    Neumeister, P.2    Brezinschek, R.3
  • 85
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20:4420-4427.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 86
    • 20144387627 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
    • Orlowski RZ, Voorhees PM, Garcia RA et al. Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood 2005;105: 3058-3065.
    • (2005) Blood , vol.105 , pp. 3058-3065
    • Orlowski, R.Z.1    Voorhees, P.M.2    Garcia, R.A.3
  • 87
    • 20044376092 scopus 로고    scopus 로고
    • Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma
    • O' Connor OA, Wright J, Moskowitz C et al. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol 2005;23:676-684.
    • (2005) J Clin Oncol , vol.23 , pp. 676-684
    • O' Connor, O.A.1    Wright, J.2    Moskowitz, C.3
  • 88
    • 33646462752 scopus 로고    scopus 로고
    • Bortezomib therapy in patients with relapsed or refractory lymphoma: Potential correlation of in vitro sensitivity and tumor necrosis factor alpha response with clinical activity
    • Strauss SJ, Maharaj L, Hoare S et al. Bortezomib therapy in patients with relapsed or refractory lymphoma: Potential correlation of in vitro sensitivity and tumor necrosis factor alpha response with clinical activity. J Clin Oncol 2006;24:2105-2112.
    • (2006) J Clin Oncol , vol.24 , pp. 2105-2112
    • Strauss, S.J.1    Maharaj, L.2    Hoare, S.3
  • 89
    • 20044396543 scopus 로고    scopus 로고
    • Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Goy A, Younes A, McLaughlin P et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 2005;23:667-675.
    • (2005) J Clin Oncol , vol.23 , pp. 667-675
    • Goy, A.1    Younes, A.2    McLaughlin, P.3
  • 90
    • 33747875167 scopus 로고    scopus 로고
    • Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia
    • Faderl S, Rai K, Gribben J et al. Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. Cancer 2006;107:916-924.
    • (2006) Cancer , vol.107 , pp. 916-924
    • Faderl, S.1    Rai, K.2    Gribben, J.3
  • 91
    • 33846530661 scopus 로고    scopus 로고
    • A phase II study of bortezomib in mantle cell lymphoma: The National Cancer Institute of Canada Clinical Trials Group trial IND.150
    • Belch A, Kouroukis CT, Crump M et al. A phase II study of bortezomib in mantle cell lymphoma: The National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol 2007;18:116-121.
    • (2007) Ann Oncol , vol.18 , pp. 116-121
    • Belch, A.1    Kouroukis, C.T.2    Crump, M.3
  • 92
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher RI, Bernstein SH, Kahl BS et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol 2006;24: 4867-4874
    • (2006) J Clin Oncol , vol.24 , pp. 4867-4874
    • Fisher, R.I.1    Bernstein, S.H.2    Kahl, B.S.3
  • 93
    • 61649094981 scopus 로고    scopus 로고
    • Bortezomib in patients with relapsed or refractory mantle cell lymphoma: Updated time-to-event analyses of the multicenter phase 2 PINNACLE study
    • Goy A, Bernstein SH, Kahl BS et al. Bortezomib in patients with relapsed or refractory mantle cell lymphoma: Updated time-to-event analyses of the multicenter phase 2 PINNACLE study. Ann Oncol 2009;20: 520-525.
    • (2009) Ann Oncol , vol.20 , pp. 520-525
    • Goy, A.1    Bernstein, S.H.2    Kahl, B.S.3
  • 94
    • 61849128387 scopus 로고    scopus 로고
    • Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre phase 2 clinical trial
    • O'Connor OA, Moskowitz C, Portlock C et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre phase 2 clinical trial. Br J Haematol 2009;145:34-39.
    • (2009) Br J Haematol , vol.145 , pp. 34-39
    • O'Connor, O.A.1    Moskowitz, C.2    Portlock, C.3
  • 95
    • 77954134911 scopus 로고    scopus 로고
    • Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial
    • Goy A, Bernstein SH, McDonald A et al. Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial. Leuk Lymphoma 2010;51:1269-1277.
    • (2010) Leuk Lymphoma , vol.51 , pp. 1269-1277
    • Goy, A.1    Bernstein, S.H.2    McDonald, A.3
  • 96
    • 50249150555 scopus 로고    scopus 로고
    • Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies [abstract]
    • Abstract 411
    • Alsina M, Trudel S, Vallone M et al. Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies [abstract]. Blood 2007; 110:Abstract 411.
    • (2007) Blood , vol.110
    • Alsina, M.1    Trudel, S.2    Vallone, M.3
  • 97
    • 50249138003 scopus 로고    scopus 로고
    • Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: Phase 1 results [abstract]
    • Abstract 409
    • Orlowski RZ, Stewart K, Vallone M et al. Safety and antitumor efficacy of the proteasome inhibitor carfilzomib (PR-171) dosed for five consecutive days in hematologic malignancies: Phase 1 results [abstract]. Blood 2007;110:Abstract 409.
    • (2007) Blood , vol.110
    • Orlowski, R.Z.1    Stewart, K.2    Vallone, M.3
  • 98
    • 50249165115 scopus 로고    scopus 로고
    • Phase I study of the novel proteasome inhibitor NPI-0052 in patients with lymphoma and solid tumors
    • Abstract 3574
    • Aghajanian CA, Hamlin P, Gordon MS et al. Phase I study of the novel proteasome inhibitor NPI-0052 in patients with lymphoma and solid tumors. J Clin Oncol 2008;26(15 suppl):Abstract 3574.
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Aghajanian, C.A.1    Hamlin, P.2    Gordon, M.S.3
  • 99
    • 79958764877 scopus 로고    scopus 로고
    • Phase 2 trial of rituximab and bortezomib in patients with relapsed or refractory mantle cell and follicular lymphoma
    • Baiocchi RA, Alinari L, Lustberg ME et al. Phase 2 trial of rituximab and bortezomib in patients with relapsed or refractory mantle cell and follicular lymphoma. Cancer 2011;117:2355-2581.
    • (2011) Cancer , vol.117 , pp. 2355-2581
    • Baiocchi, R.A.1    Alinari, L.2    Lustberg, M.E.3
  • 100
    • 77958541490 scopus 로고    scopus 로고
    • Weekly versus twice weekly bortezomib given in conjunction with rituximab, in patients with recurrent follicular lymphoma, mantle cell lymphoma and Waldenstrom macroglobulinaemia
    • Agathocleous A, Rohatiner A, Rule S et al. Weekly versus twice weekly bortezomib given in conjunction with rituximab, in patients with recurrent follicular lymphoma, mantle cell lymphoma and Waldenstrom macroglobulinaemia. Br J Haematol 2010; 151:346-353.
    • (2010) Br J Haematol , vol.151 , pp. 346-353
    • Agathocleous, A.1    Rohatiner, A.2    Rule, S.3
  • 101
    • 84859749297 scopus 로고    scopus 로고
    • Weekly infusion of bortezomib in combination with rituximab in relapsed/refractory indolent non-follicular and mantle cell lymphoma is safe and effective: Two-years analysis of phase II trial BRIL06 of Intergruppo Italiano Linfomi (IIL) [abstract]
    • Abstract 3965
    • Chiappella A, Pregno P, Zinzani PL et al. Weekly infusion of bortezomib in combination with rituximab in relapsed/refractory indolent non-follicular and mantle cell lymphoma is safe and effective: Two-years analysis of phase II trial BRIL06 of Intergruppo Italiano Linfomi (IIL) [abstract]. Blood 2010;116:Abstract 3965.
    • (2010) Blood , vol.116
    • Chiappella, A.1    Pregno, P.2    Zinzani, P.L.3
  • 102
    • 79953000969 scopus 로고    scopus 로고
    • A phase II trial of bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma (MCL) (CALGB 50501): Results of a planned interim analysis
    • Abstract 8106
    • Morrison VA, Johnson JL, Jung S et al. A phase II trial of bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma (MCL) (CALGB 50501): Results of a planned interim analysis. J Clin Oncol 2010; 28(15 suppl):Abstract 8106.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Morrison, V.A.1    Johnson, J.L.2    Jung, S.3
  • 103
    • 84862908084 scopus 로고    scopus 로고
    • A phase I study evaluating ibritumomab tiuxetan (Zevalin®) in combination with bortezomib (Velcade®) in relapsed/ refractory mantle cell and low grade B-cell non-Hodgkin lymphoma
    • Beaven AW, Shea TC, Moore DT et al. A phase I study evaluating ibritumomab tiuxetan (Zevalin®) in combination with bortezomib (Velcade®) in relapsed/ refractory mantle cell and low grade B-cell non-Hodgkin lymphoma. Leuk Lymphoma. 2012;53:254-258.
    • (2012) Leuk Lymphoma , vol.53 , pp. 254-258
    • Beaven, A.W.1    Shea, T.C.2    Moore, D.T.3
  • 104
    • 84872755951 scopus 로고    scopus 로고
    • A phase I trial of PS-341 and fludarabine for relapsed and refractory indolent non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • Abstract 7580
    • Snell M, Koc ON, Bahlis NJ et al. A phase I trial of PS-341 and fludarabine for relapsed and refractory indolent non-Hodgkin's lymphoma and chronic lymphocytic leukemia. J Clin Oncol 2006;24(18 suppl):Abstract 7580.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Snell, M.1    Koc, O.N.2    Bahlis, N.J.3
  • 105
    • 68549133393 scopus 로고    scopus 로고
    • A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma-long-term results of a multi-center observation study
    • Weigert O, Weidmann E, Mueck R et al. A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma-long-term results of a multi-center observation study. Leuk Lymphoma 2009;50: 716-722.
    • (2009) Leuk Lymphoma , vol.50 , pp. 716-722
    • Weigert, O.1    Weidmann, E.2    Mueck, R.3
  • 106
    • 79951700533 scopus 로고    scopus 로고
    • A phase II study of bortezomib and gemcitabine in relapsed mantle cell lymphoma from the National Cancer Institute of Canada Clinical Trials Group (IND 172)
    • Kouroukis CT, Fernandez LA, Crump M et al. A phase II study of bortezomib and gemcitabine in relapsed mantle cell lymphoma from the National Cancer Institute of Canada Clinical Trials Group (IND 172). Leul Lymphoma 2011;52:394-399.
    • (2011) Leul Lymphoma , vol.52 , pp. 394-399
    • Kouroukis, C.T.1    Fernandez, L.A.2    Crump, M.3
  • 107
    • 76449114029 scopus 로고    scopus 로고
    • Fludarabine, bortezomib, Myocet and rituximab chemotherapy in relapsed and refractory mantle cell lymphoma
    • Orciuolo E, Buda G, Pelosini M et al. Fludarabine, bortezomib, Myocet and rituximab chemotherapy in relapsed and refractory mantle cell lymphoma. Br J Haematol 2010;148:810-812.
    • (2010) Br J Haematol , vol.148 , pp. 810-812
    • Orciuolo, E.1    Buda, G.2    Pelosini, M.3
  • 108
    • 84907341181 scopus 로고    scopus 로고
    • A pilot study with rituximab, bortezomib and hyper-fractionated cyclophosphamide (RBC regimen) for the treatment of advanced mantle cell lymphoma in elderly patients
    • Abstract 0273
    • Musty PM, Guariglia R, Pietrantuono G et al. A pilot study with rituximab, bortezomib and hyper-fractionated cyclophosphamide (RBC regimen) for the treatment of advanced mantle cell lymphoma in elderly patients. Haematologica 2008;93(suppl 1):Abstract 0273.
    • Haematologica , vol.2008 , Issue.SUPPL. 1
    • Musty, P.M.1    Guariglia, R.2    Pietrantuono, G.3
  • 109
    • 84872757469 scopus 로고    scopus 로고
    • Rituximab, cyclophosphamide, bortezomib and prednisone (R-CBorP): Final results of a phase I trial evaluating two dosing schedules and the safety of overlapping pegfilgrastim in patients with relapsed/refractory indolent and mantle cell lymphomas [abstract]
    • Abstract 3708
    • Gerecitano J, Portlock CS, Hamlin PA Jr et al. Rituximab, cyclophosphamide, bortezomib and prednisone (R-CBorP): Final results of a phase I trial evaluating two dosing schedules and the safety of overlapping pegfilgrastim in patients with relapsed/refractory indolent and mantle cell lymphomas [abstract]. Blood 2009; 114:Abstract 3708.
    • (2009) Blood , vol.114
    • Gerecitano, J.1    Portlock, C.S.2    Hamlin Jr., P.A.3
  • 110
    • 79953077610 scopus 로고    scopus 로고
    • The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
    • Friedberg JW, Vose JM, Kelly JL et al. The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma. Blood 2011;117:2807-2812.
    • (2011) Blood , vol.117 , pp. 2807-2812
    • Friedberg, J.W.1    Vose, J.M.2    Kelly, J.L.3
  • 111
    • 79953666766 scopus 로고    scopus 로고
    • Bortezomib, rituximab, and dexamethasone (BORID) as salvage treatment in relapsed/refractory mantle cell lymphoma: Sustained disease control in patients achieving a complete remission [abstract]
    • Abstract 2578
    • Drach J, Kaufmann H, Pichelmayer O et al. Bortezomib, rituximab, and dexamethasone (BORID) as salvage treatment in relapsed/refractory mantle cell lymphoma: Sustained disease control in patients achieving a complete remission [abstract]. Blood 2007;110: Abstract 2578.
    • (2007) Blood , vol.110
    • Drach, J.1    Kaufmann, H.2    Pichelmayer, O.3
  • 112
    • 79960494175 scopus 로고    scopus 로고
    • Final results of the RiPAD+C regimen including Velcade in front line therapy for elderly patients with mantle cell lymphoma. A phase II prospective study of the GOELAMS group [abstract]
    • Abstract 2791
    • Gressin R, Houot R, Uribe MO et al. Final results of the RiPAD+C regimen including Velcade in front line therapy for elderly patients with mantle cell lymphoma. A phase II prospective study of the GOELAMS group [abstract]. Blood 2010;116:Abstract 2791.
    • (2010) Blood , vol.116
    • Gressin, R.1    Houot, R.2    Uribe, M.O.3
  • 113
    • 68549132830 scopus 로고    scopus 로고
    • Phase I trial of bortezomib in combination with rituximabhyperCVAD/methotrexate and cytarabine for untreated mantle cell lymphoma [abstract]
    • Abstract 3051
    • Romaguera J, Fayad L, McLaughlin P et al. Phase I trial of bortezomib in combination with rituximabhyperCVAD/methotrexate and cytarabine for untreated mantle cell lymphoma [abstract]. Blood 2008;112: Abstract 3051.
    • (2008) Blood , vol.112
    • Romaguera, J.1    Fayad, L.2    McLaughlin, P.3
  • 114
    • 77956853122 scopus 로고    scopus 로고
    • Phase I trial of bortezomib in combination with rituximab-hyperCVAD alternating with rituximab, methotrexate and cytarabine for untreated aggressive mantle cell lymphoma
    • Romaguera JE, Fayad LE, McLaughlin P et al. Phase I trial of bortezomib in combination with rituximab-hyperCVAD alternating with rituximab, methotrexate and cytarabine for untreated aggressive mantle cell lymphoma. Br J Haematol 2010;151:47-53.
    • (2010) Br J Haematol , vol.151 , pp. 47-53
    • Romaguera, J.E.1    Fayad, L.E.2    McLaughlin, P.3
  • 115
    • 70349744106 scopus 로고    scopus 로고
    • VcR-CVAD produces a high complete response rate in untreated mantle cell lymphoma: A phase II study from the Wisconsin oncology network [abstract]
    • Abstract 265
    • Kahl B, Chang J, Eickhoff J et al. VcR-CVAD produces a high complete response rate in untreated mantle cell lymphoma: A phase II study from the Wisconsin oncology network [abstract]. Blood 2008;112: Abstract 265.
    • (2008) Blood , vol.112
    • Kahl, B.1    Chang, J.2    Eickhoff, J.3
  • 116
    • 40849143771 scopus 로고    scopus 로고
    • A phase 1 trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma [abstract]
    • Abstract 2569
    • Goy A, Ford P, Feldman T et al. A phase 1 trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma [abstract]. Blood 2007;110:Abstract 2569.
    • (2007) Blood , vol.110
    • Goy, A.1    Ford, P.2    Feldman, T.3
  • 117
    • 50049092599 scopus 로고    scopus 로고
    • Treatment of follicular non-Hodgkin's lymphoma: The old and the new
    • Friedberg JW. Treatment of follicular non-Hodgkin's lymphoma: The old and the new. Semin Hematol 2008;45(suppl 2):S2-S6.
    • (2008) Semin Hematol , vol.45 , Issue.SUPPL. 2
    • Friedberg, J.W.1
  • 118
    • 33645538920 scopus 로고    scopus 로고
    • Mechanistic rationale and clinical evidence for the efficacy of proteasome inhibitors against indolent and mantle cell lymphomas
    • Paoluzzi L, O'Connor OA. Mechanistic rationale and clinical evidence for the efficacy of proteasome inhibitors against indolent and mantle cell lymphomas. BioDrugs 2006;20:13-23.
    • (2006) BioDrugs , vol.20 , pp. 13-23
    • Paoluzzi, L.1    O'Connor, O.A.2
  • 119
    • 77449160650 scopus 로고    scopus 로고
    • Results of a phase 2 study of bortezomib in patients with relapsed or refractory indolent lymphoma
    • Di Bella N, Taetle R, Kolibaba K et al. Results of a phase 2 study of bortezomib in patients with relapsed or refractory indolent lymphoma. Blood 2010;115:475-480.
    • (2010) Blood , vol.115 , pp. 475-480
    • di Bella, N.1    Taetle, R.2    Kolibaba, K.3
  • 120
    • 79960892893 scopus 로고    scopus 로고
    • Final results of a randomized phase 2 multicenter study of two bortezomib schedules in patients with recurrent or refractory follicular lymphoma. Groupe d'Etude des Lym- phomes de l'Adulte (GELA) study FL-05 [abstract]
    • Abstract 768
    • Ribrag V, Tilly H, Casasnovas O et al. Final results of a randomized phase 2 multicenter study of two bortezomib schedules in patients with recurrent or refractory follicular lymphoma. Groupe d'Etude des Lym- phomes de l'Adulte (GELA) study FL-05 [abstract]. Blood 2010;116:Abstract 768.
    • (2010) Blood , vol.116
    • Ribrag, V.1    Tilly, H.2    Casasnovas, O.3
  • 121
    • 74549164108 scopus 로고    scopus 로고
    • Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes
    • O'Connor OA, Portlock C, Moskowitz C et al. Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes. Clin Cancer Res 2010; 16:719-726.
    • (2010) Clin Cancer Res , vol.16 , pp. 719-726
    • O'Connor, O.A.1    Portlock, C.2    Moskowitz, C.3
  • 122
    • 77349086121 scopus 로고    scopus 로고
    • Multicenter randomized phase II study of weekly or twice-weekly bortezomib plus rituximab in patients with relapsed or refractory follicular or marginal-zone B-cell lymphoma
    • de Vos S, Goy A, Dakhil SR et al. Multicenter randomized phase II study of weekly or twice-weekly bortezomib plus rituximab in patients with relapsed or refractory follicular or marginal-zone B-cell lymphoma. J Clin Oncol 2009;27:5023-5030.
    • (2009) J Clin Oncol , vol.27 , pp. 5023-5030
    • de Vos, S.1    Goy, A.2    Dakhil, S.R.3
  • 123
    • 79960892918 scopus 로고    scopus 로고
    • Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: A randomised phase 3 trial
    • Coiffier B, Osmanov EA, Hong X et al. Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. Lancet Oncol. 2011;12:773-784.
    • (2011) Lancet Oncol , vol.12 , pp. 773-784
    • Coiffier, B.1    Osmanov, E.A.2    Hong, X.3
  • 124
    • 84872757851 scopus 로고    scopus 로고
    • Identification of patient subgroups demonstrating longer progressionfree survival (PFS) benefit with bortezomib-rituximab versus rituximab in patients with relapsed or refractory follicular lymphoma (FL): Biomarker analyses of the phase 3 LYM3001 study [abstract]
    • Abstract 265
    • Coiffier B, Li W, Henitz ED et al. Identification of patient subgroups demonstrating longer progressionfree survival (PFS) benefit with bortezomib-rituximab versus rituximab in patients with relapsed or refractory follicular lymphoma (FL): biomarker analyses of the phase 3 LYM3001 study [abstract]. Blood 2011;118: Abstract 265.
    • (2011) Blood , vol.118
    • Coiffier, B.1    Li, W.2    Henitz, E.D.3
  • 125
    • 77956129368 scopus 로고    scopus 로고
    • A randomized, open-label, multicenter phase II study of bortezomib with fludarabine in comparison to rituximab with fludarabine in follicular lymphoma subjects previously treated with rituximab
    • Abstract TPS303
    • Theocharous P, Shpilberg O, Elsayed YA. A randomized, open-label, multicenter phase II study of bortezomib with fludarabine in comparison to rituximab with fludarabine in follicular lymphoma subjects previously treated with rituximab. J Clin Oncol 2010;28(15 suppl):Abstract TPS303.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Theocharous, P.1    Shpilberg, O.2    Elsayed, Y.A.3
  • 126
    • 70349205461 scopus 로고    scopus 로고
    • Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma
    • Barr PM, Fu P, Lazarus HM et al. Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma. Br J Haematol 2009;147:89-96.
    • (2009) Br J Haematol , vol.147 , pp. 89-96
    • Barr, P.M.1    Fu, P.2    Lazarus, H.M.3
  • 127
    • 77956668781 scopus 로고    scopus 로고
    • Bendamustine, bortezomib and rituximab in patients (pts) relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma (NHL): A multicenter phase II clinical trial [abstract]
    • Abstract 924
    • Friedberg JW, Vose JM, Kelly JL et al. Bendamustine, bortezomib and rituximab in patients (pts) relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma (NHL): A multicenter phase II clinical trial [abstract]. Blood 2009;114:Abstract 924.
    • (2009) Blood , vol.114
    • Friedberg, J.W.1    Vose, J.M.2    Kelly, J.L.3
  • 128
    • 80052746696 scopus 로고    scopus 로고
    • Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: The phase II VERTICAL study
    • Fowler N, Kahl BS, Lee P et al. Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: The phase II VERTICAL study. J Clin Oncol 2011;29:3389-3395.
    • (2011) J Clin Oncol , vol.29 , pp. 3389-3395
    • Fowler, N.1    Kahl, B.S.2    Lee, P.3
  • 129
    • 79960891189 scopus 로고    scopus 로고
    • Bortezomib in combination with rituximab, cyclophosphamide, and prednisone with or without doxorubicin followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma: Results of a phase 2 study [abstract]
    • Abstract 2798
    • Craig M, Hanna WT, Cabanillas F et al. Bortezomib in combination with rituximab, cyclophosphamide, and prednisone with or without doxorubicin followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma: Results of a phase 2 study [abstract]. Blood 2010;116:Abstract 2798.
    • (2010) Blood , vol.116
    • Craig, M.1    Hanna, W.T.2    Cabanillas, F.3
  • 130
    • 80052739391 scopus 로고    scopus 로고
    • Bortezomib added to R-CVP is safe and effective for previously untreated advanced-stage follicular lymphoma: A phase II study by the National Cancer Institute of Canada Clinical Trials Group
    • Sehn LH, Macdonald D, Rubin S et al. Bortezomib added to R-CVP is safe and effective for previously untreated advanced-stage follicular lymphoma: A phase II study by the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2011;29:3396-3401.
    • (2011) J Clin Oncol , vol.29 , pp. 3396-3401
    • Sehn, L.H.1    Macdonald, D.2    Rubin, S.3
  • 131
    • 80052696399 scopus 로고    scopus 로고
    • Is there a role for bortezomib combinations in the management of patients with follicular lymphoma?
    • Salles G. Is there a role for bortezomib combinations in the management of patients with follicular lymphoma? J Clin Oncol 2011;29:3349-3350.
    • (2011) J Clin Oncol , vol.29
    • Salles, G.1
  • 132
    • 84907361286 scopus 로고    scopus 로고
    • Bortezomib (Velcade), rituximab, cyclophosphamide, dexamethasone (VRCD) combination therapy in front-line lowgrade non-Hodgkin lymphoma (LG-NHL) is active in elderly patient population [abstract]
    • Abstract 1769
    • Nabhan C, Dalal N, Tolzien K et al. Bortezomib (Velcade), rituximab, cyclophosphamide, dexamethasone (VRCD) combination therapy in front-line lowgrade non-Hodgkin lymphoma (LG-NHL) is active in elderly patient population [abstract]. Blood 2010;116: Abstract 1769.
    • (2010) Blood , vol.116
    • Nabhan, C.1    Dalal, N.2    Tolzien, K.3
  • 133
    • 45749152667 scopus 로고    scopus 로고
    • Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    • Wilson WH, Dunleavy K, Pittaluga S et al. Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers. J Clin Oncol 2008;26:2717-2724.
    • (2008) J Clin Oncol , vol.26 , pp. 2717-2724
    • Wilson, W.H.1    Dunleavy, K.2    Pittaluga, S.3
  • 134
    • 53749093794 scopus 로고    scopus 로고
    • Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and nongerminal center B-cell-like subtypes of diffuse large B-cell lymphoma
    • Fu K, Weisenburger DD, Choi WW et al. Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and nongerminal center B-cell-like subtypes of diffuse large B-cell lymphoma. J Clin Oncol 2008;26:4587-4594.
    • (2008) J Clin Oncol , vol.26 , pp. 4587-4594
    • Fu, K.1    Weisenburger, D.D.2    Choi, W.W.3
  • 135
    • 79961096440 scopus 로고    scopus 로고
    • Survival impact of rituximab combined with ACVBP and upfront consolidative autotransplantation in high risk diffuse large B-cell lymphoma for GELA
    • Fitoussi O, Belhadj K, Mounier N et al. Survival impact of rituximab combined with ACVBP and upfront consolidative autotransplantation in high risk diffuse large B-cell lymphoma for GELA. Haematologica 2011; 96:1136-1143.
    • (2011) Haematologica , vol.96 , pp. 1136-1143
    • Fitoussi, O.1    Belhadj, K.2    Mounier, N.3
  • 136
    • 33748661970 scopus 로고    scopus 로고
    • Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poor-risk diffuse large B-cell lymphoma
    • van Imhoff GW, Boerma EJ, van der Holt B et al. Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poor-risk diffuse large B-cell lymphoma. J Clin Oncol 2006;24:4135-4142.
    • (2006) J Clin Oncol , vol.24 , pp. 4135-4142
    • van Imhoff, G.W.1    Boerma, E.J.2    van der Holt, B.3
  • 137
    • 80053191352 scopus 로고    scopus 로고
    • Evaluation of prognostic values of clinical and histopathologic characteristics in diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy
    • Hong J, Park S, Park J et al. Evaluation of prognostic values of clinical and histopathologic characteristics in diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy. Leuk Lymphoma 2011;52: 1904-1912.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1904-1912
    • Hong, J.1    Park, S.2    Park, J.3
  • 138
    • 77956578834 scopus 로고    scopus 로고
    • MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: Rationale for treatment of NF-KB-dependent lymphoma
    • Milhollen MA, Traore T, Adams-Duffy J et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: Rationale for treatment of NF-KB-dependent lymphoma. Blood 2010;116:1515-1523.
    • (2010) Blood , vol.116 , pp. 1515-1523
    • Milhollen, M.A.1    Traore, T.2    Adams-Duffy, J.3
  • 139
    • 16844374736 scopus 로고    scopus 로고
    • Phase I/II study of bortezomib alone and bortezomib with dose-adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-cell lymphoma [abstract]
    • Abstract 1385
    • Dunleavy K, Janik J, Gea-Banacloche J et al. Phase I/II study of bortezomib alone and bortezomib with dose-adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-cell lymphoma [abstract]. Blood 2004;104:Abstract 1385.
    • (2004) Blood , vol.104
    • Dunleavy, K.1    Janik, J.2    Gea-Banacloche, J.3
  • 140
    • 84872755095 scopus 로고    scopus 로고
    • A phase I trial of bortezomib plus CHOP every 2 weeks in patients with advanced stage diffuse large B-cell lymphomas [abstract]
    • Abstract 4446
    • Jang G, Sym SJ, Kim S et al. A phase I trial of bortezomib plus CHOP every 2 weeks in patients with advanced stage diffuse large B-cell lymphomas [abstract]. Blood 2007;110:Abstract 4446.
    • (2007) Blood , vol.110
    • Jang, G.1    Sym, S.J.2    Kim, S.3
  • 141
    • 79952154013 scopus 로고    scopus 로고
    • Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma
    • Ruan J, Martin P, Furman RR et al. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma. J Clin Oncol 2011;29:690-697.
    • (2011) J Clin Oncol , vol.29 , pp. 690-697
    • Ruan, J.1    Martin, P.2    Furman, R.R.3
  • 142
    • 35348876311 scopus 로고    scopus 로고
    • Efficacy and toxicity of two schedules of R-CHOP plus bortezomib in front-line B lymphoma patients: A randomized phase II trial from the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
    • Abstract 8010
    • Mounier N, Ribrag V, Haioun C et al. Efficacy and toxicity of two schedules of R-CHOP plus bortezomib in front-line B lymphoma patients: A randomized phase II trial from the Groupe d'Etude des Lymphomes de l'Adulte (GELA). J Clin Oncol 2007; 25(18 suppl):Abstract 8010.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Mounier, N.1    Ribrag, V.2    Haioun, C.3
  • 143
    • 67650398258 scopus 로고    scopus 로고
    • Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    • Dunleavy K, Pittaluga S, Czuczman MS et al. Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma. Blood 2009;113:6069-6076.
    • (2009) Blood , vol.113 , pp. 6069-6076
    • Dunleavy, K.1    Pittaluga, S.2    Czuczman, M.S.3
  • 144
    • 79958848664 scopus 로고    scopus 로고
    • Rapid prospective identification of non-germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) patients for targeted trials: Early results from PYRAMID, a phase 2 randomized study of R-CHOP ±- bortezomib in newly diagnosed non-GCB DLBCL [abstract]
    • Abstract 1792
    • Doner K, Flinn IW, Ulrich BK et al. Rapid prospective identification of non-germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) patients for targeted trials: Early results from PYRAMID, a phase 2 randomized study of R-CHOP ±- bortezomib in newly diagnosed non-GCB DLBCL [abstract]. Blood 2010;116:Abstract 1792.
    • (2010) Blood , vol.116
    • Doner, K.1    Flinn, I.W.2    Ulrich, B.K.3
  • 145
    • 68949135695 scopus 로고    scopus 로고
    • Primary therapy of Waldenstrom macroglobulinemia with bortezomib, dexamethasone and rituximab: WMCTG clinical trial 05-180
    • Treon SP, Ioakimidis L, Soumerai JD et al. Primary therapy of Waldenstrom macroglobulinemia with bortezomib, dexamethasone and rituximab: WMCTG clinical trial 05-180. J Clin Oncol 2009;27:3830-3835.
    • (2009) J Clin Oncol , vol.27 , pp. 3830-3835
    • Treon, S.P.1    Ioakimidis, L.2    Soumerai, J.D.3
  • 146
    • 85042316900 scopus 로고    scopus 로고
    • Phase II trial of combination of bortezomib and rituximab in relapsed and/or refractory Waldenstrom macroglobulinemia [abstract]
    • Abstract 832
    • Ghobrial IM, Matous J, Padmanabhan S et al. Phase II trial of combination of bortezomib and rituximab in relapsed and/or refractory Waldenstrom macroglobulinemia [abstract]. Blood 2008;112:Abstract 832.
    • (2008) Blood , vol.112
    • Ghobrial, I.M.1    Matous, J.2    Padmanabhan, S.3
  • 147
    • 56749102974 scopus 로고    scopus 로고
    • Phase I study of proteasome inhibitor bortezomib plus CHOP in patients with advanced, aggressive T-cell or NK/T-cell lymphoma
    • Lee J, Suh C, Kang HJ et al. Phase I study of proteasome inhibitor bortezomib plus CHOP in patients with advanced, aggressive T-cell or NK/T-cell lymphoma. Ann Oncol 2008;19:2079-2083.
    • (2008) Ann Oncol , vol.19 , pp. 2079-2083
    • Lee, J.1    Suh, C.2    Kang, H.J.3
  • 148
    • 71649099425 scopus 로고    scopus 로고
    • Phase I results of combination gemcitabine and bortezomib (Velcade®) for relapsed/refractory nodal T-cell non-Hodgkin lymphoma (T-NHL) and aggressive B-cell NHL (B-NHL) [abstract]
    • Abstract 2005
    • Evens AM, Gordon LI, Patton D et al. Phase I results of combination gemcitabine and bortezomib (Velcade®) for relapsed/refractory nodal T-cell non-Hodgkin lymphoma (T-NHL) and aggressive B-cell NHL (B-NHL) [abstract]. Blood 2008;112:Abstract 2005.
    • (2008) Blood , vol.112
    • Evens, A.M.1    Gordon, L.I.2    Patton, D.3
  • 149
    • 35348895303 scopus 로고    scopus 로고
    • Cutaneous T cell lymphoma: Responses in phase 1 trial of combination therapy with liposomal doxorubicin, bortezomib, and gemcitabine [abstract]
    • Abstract 2466
    • Dhillon N, Bakkannagari S, Ng C et al. Cutaneous T cell lymphoma: Responses in phase 1 trial of combination therapy with liposomal doxorubicin, bortezomib, and gemcitabine [abstract]. Blood 2006;108:Abstract 2466.
    • (2006) Blood , vol.108
    • Dhillon, N.1    Bakkannagari, S.2    Ng, C.3
  • 150
    • 70449662856 scopus 로고    scopus 로고
    • A phase II study of bortezomib in combination with intensified CHOP-like regimen (ACVBP) in patients with previously untreated T-cell lymphoma: Results of the GELA LNH05-1T trial
    • Abstract 8554
    • Delmer A, Fitoussi O, Gaulard P et al. A phase II study of bortezomib in combination with intensified CHOP-like regimen (ACVBP) in patients with previously untreated T-cell lymphoma: Results of the GELA LNH05-1T trial. J Clin Oncol 2009;27(15 suppl):Abstract 8554.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Delmer, A.1    Fitoussi, O.2    Gaulard, P.3
  • 151
    • 34948833649 scopus 로고    scopus 로고
    • Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma
    • Zinzani PL, Musuraca G, Tani M et al. Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol 2007;25:4293-4297.
    • (2007) J Clin Oncol , vol.25 , pp. 4293-4297
    • Zinzani, P.L.1    Musuraca, G.2    Tani, M.3
  • 152
    • 77954755959 scopus 로고    scopus 로고
    • Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies
    • Marchi E, Paoluzzi L, Scotto L et al. Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin Cancer Res 2010;16:3648-3658.
    • (2010) Clin Cancer Res , vol.16 , pp. 3648-3658
    • Marchi, E.1    Paoluzzi, L.2    Scotto, L.3
  • 153
    • 70349658396 scopus 로고    scopus 로고
    • Outcome of treatment of Epstein-Barr virus-related post-transplant lymphoproliferative disorder in hematopoietic stem cell recipients: A comprehensive review of reported cases
    • Styczynski J, Einsele H, Gil L et al. Outcome of treatment of Epstein-Barr virus-related post-transplant lymphoproliferative disorder in hematopoietic stem cell recipients: A comprehensive review of reported cases. Transpl Infect Dis 2009;11:383-392.
    • (2009) Transpl Infect Dis , vol.11 , pp. 383-392
    • Styczynski, J.1    Einsele, H.2    Gil, L.3
  • 154
    • 35348878567 scopus 로고    scopus 로고
    • Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EB V-transformed B cells
    • Zou P, Kawada J, Pesnicak L et al. Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EB V-transformed B cells. J Virol 2007;81:10029-10036.
    • (2007) J Virol , vol.81 , pp. 10029-10036
    • Zou, P.1    Kawada, J.2    Pesnicak, L.3
  • 155
    • 79951690310 scopus 로고    scopus 로고
    • Second generation proteasome inhibitors: Carfilzomib and immunoproteasome-specific inhibitors (IPSIs)
    • Kuhn DJ, Orlowski RZ, Bjorklund CC. Second generation proteasome inhibitors: Carfilzomib and immunoproteasome-specific inhibitors (IPSIs). Curr Cancer Drug Targets 2011;11:285-295.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 285-295
    • Kuhn, D.J.1    Orlowski, R.Z.2    Bjorklund, C.C.3
  • 156
    • 66549099025 scopus 로고    scopus 로고
    • Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
    • Kuhn DJ, Hunsucker SA, Chen Q et al. Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. Blood 2009;113: 4667-4676.
    • (2009) Blood , vol.113 , pp. 4667-4676
    • Kuhn, D.J.1    Hunsucker, S.A.2    Chen, Q.3
  • 157
    • 46049100809 scopus 로고    scopus 로고
    • Bortezomib: A novel chemotherapeutic agent for hematologic malignancies
    • Utecht KN, Kolesar J. Bortezomib: A novel chemotherapeutic agent for hematologic malignancies. Am J Health Syst Pharm 2008;65:1221-1231.
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 1221-1231
    • Utecht, K.N.1    Kolesar, J.2
  • 158
    • 43049115407 scopus 로고    scopus 로고
    • Bortezomib in mantle cell lymphoma
    • Suh KS, Goy A. Bortezomib in mantle cell lymphoma. Future Oncol 2008;4:149-168.
    • (2008) Future Oncol , vol.4 , pp. 149-168
    • Suh, K.S.1    Goy, A.2
  • 159
    • 79958747274 scopus 로고    scopus 로고
    • Preliminary results of a phase I/II study of weekly or twice weekly bortezomib in combination with rituximab, in patients with follicular lymphoma, mantle cell lymphoma and Waldenstrom' s macroglobulinaemia [abstract]
    • Abstract 2559
    • Agathocleous A, Rule S, Johnson P et al. Preliminary results of a phase I/II study of weekly or twice weekly bortezomib in combination with rituximab, in patients with follicular lymphoma, mantle cell lymphoma and Waldenstrom' s macroglobulinaemia [abstract]. Blood 2007;110:Abstract 2559.
    • (2007) Blood , vol.110
    • Agathocleous, A.1    Rule, S.2    Johnson, P.3
  • 160
    • 70349221851 scopus 로고    scopus 로고
    • Weekly treatment with a combination of bendamustine and bortezomib in relapsed or refractory indolent non-Hodgkin's lymphoma: A single-center phase 1/2 study [abstract]
    • Abstract 1574
    • Moosmann PR, Heizmann M, Kotrubczik N et al. Weekly treatment with a combination of bendamustine and bortezomib in relapsed or refractory indolent non-Hodgkin's lymphoma: A single-center phase 1/2 study [abstract]. Blood 2008;112:Abstract 1574.
    • (2008) Blood , vol.112
    • Moosmann, P.R.1    Heizmann, M.2    Kotrubczik, N.3
  • 161
    • 33746010219 scopus 로고    scopus 로고
    • Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
    • Richardson PG, Briemberg H, Jagannath S et al. Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 2006;24:3113-3120.
    • (2006) J Clin Oncol , vol.24 , pp. 3113-3120
    • Richardson, P.G.1    Briemberg, H.2    Jagannath, S.3
  • 162
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study
    • Moreau P, Pylypenko H, Grosicki S et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study. Lancet Oncol 2011;12:431-440.
    • (2011) Lancet Oncol , vol.12 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3
  • 163
    • 34648824397 scopus 로고    scopus 로고
    • Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics
    • Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics. Nat Rev Cancer 2007;7:750-762.
    • (2007) Nat Rev Cancer , vol.7 , pp. 750-762
    • Jares, P.1    Colomer, D.2    Campo, E.3


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