Preconditioning the brain: Moving on to the next frontier of neurotherapeutics

Stroke

Volumn 43, Issue 6, 2012, Pages 1455-1457

  Koch, Sebastian ^a   Sacco, Ralph L ^a   Perez Pinzon, Miguel A ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

neuroprotection; neuroprotective agents; treatment

Indexed keywords

BIOLOGICAL MARKER; INHALATION ANESTHETIC AGENT;

BRAIN; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CLINICAL ASSESSMENT; CLINICAL RESEARCH; CORONARY ARTERY BYPASS SURGERY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; EDITORIAL; ENVIRONMENTAL STRESS; FOOD AND DRUG ADMINISTRATION; HEART ARREST; HEART SURGERY; HOMEOSTASIS; HUMAN; HYPOTHERMIA; HYPOXIA; ISCHEMIC PRECONDITIONING; LABORATORY TEST; LIMB ISCHEMIA; MEDLINE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PEER REVIEW; PRIORITY JOURNAL; STROKE; SUBARACHNOID HEMORRHAGE; SURVIVAL RATE; UNITED STATES;

ANIMALS; BRAIN; EDUCATION; HUMANS; ISCHEMIC PRECONDITIONING; NERVOUS SYSTEM DISEASES; UNITED STATES;

EID: 84861600883     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.646919     Document Type: Editorial

References (19)

1. Lutz P, Nilsson G, Perez-Pinzon M. Anoxia tolerant animals, from a neurobiological perspective. Comp Biochem Physiol. 1995;113:3-13.
2. Drew KL, Buck CL, Barnes BM, Christian SL, Rasley BT, Harris MB. Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance. J Neurochem. 2007;102:1713-1726.
3. Kirino T, Tsujita Y, Tamura A. Induced tolerance to ischemia in gerbil hippocampal neurons. J Cereb Blood Flow Metab. 1991;11:299-307.
4. Matsushima K, Hakim AM. Transient forebrain ischemia protects against subsequent focal cerebral ischemia without changing cerebral perfusion. Stroke. 1995;26:1047-1052.
5. Perez-Pinzon MA, Xu GP, Dietrich WD, Rosenthal M, Sick TJ. Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia. J Cereb Blood Flow Metab. 1997;17:175-182.
6. Stagliano NE, Perez-Pinzon MA, Moskowitz MA, Huang PL. Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab. 1999;19:757-761.
7. Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 2006;7:437-448.
8. Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Frndova H, et al. Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study. Heart. 2006; 92:1506-1511.
9. Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011;42:1387-1391.
10. Koch S. Preconditioning the human brain: Practical considerations for proving cerebral protection. Translat Stroke Res. 2010;1:161-169.
11. Walsh SR, Nouraei SA, Tang TY, Sadat U, Carpenter RH, Gaunt ME. Remote ischemic preconditioning for cerebral and cardiac protection during carotid endarterectomy: results from a pilot randomized clinical trial. Vasc Endovascular Surg. 2010;44:434-439.
12. Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M, STAIR VI Consortium. Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke. 2009;40:2594-2600.
13. Dave KR, Saul I, Prado R, Busto R, Perez-Pinzon MA. Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest. Neurosci Lett. 2006;404:170-175.
14. Ren C, Gao X, Steinberg GK, Zhao H. Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning. Neuroscience. 2008;151: 1099-1103.
15. Jensen HA, Loukogeorgakis S, Yannopoulos F, Rimpilainen E, Petzold A, Tuominen H, et al. Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest. Circulation. 2011;123: 714-721.
16. Fisher M, Jonas S, Sacco RL, Jones S [corrected to Jonas S]. Prophylactic neuroprotection for cerebral ischemia. Stroke. 1994;25:1075-1080.
17. Vosler PS, Chen J. Potential molecular targets for translational stroke research. Stroke. 2009;40:S119-S120.
18. Iadecola C, Anrather J. Stroke research at a crossroad: asking the brain for directions. Nat Neurosci. 2011;14:1363-1368.
19. Mergenthaler P, Dirnagl U. Protective conditioning of the brain: expressway or roadblock? J Physiol. 2011;589:4147-4155.