Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: A randomised trial

The Lancet Oncology

Volumn 13, Issue 6, 2012, Pages 589-597

  Burmeister, Bryan H ^a   Henderson, Michael A ^b   Ainslie, Jill ^b   Fisher, Richard ^b   Di Iulio, Juliana ^c   Smithers, B Mark ^a   Hong, Angela ^d   Shannon, Kerwin ^d   Scolyer, Richard A ^d   Carruthers, Scott ^e   Coventry, Brendon J ^e   Babington, Scott ^f   Duprat, Joao ^g   Hoekstra, Harald J ^h   Thompson, John F ^d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Centre for Biostatistics and Clinical Trials   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f CHRISTCHURCH HOSPITAL   (New Zealand)

^g IM IN JK) Inst Do C   (Brazil)

^h UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUSTRALIA; BRAZIL; CANCER ADJUVANT THERAPY; CANCER RELAPSE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; METASTATIC MELANOMA; MULTICENTER STUDY; NECROSIS; NETHERLANDS; NEW ZEALAND; OBSERVATION; OVERALL SURVIVAL; PAIN; PRIORITY JOURNAL; RADIATION DERMATITIS; RANDOMIZED CONTROLLED TRIAL; RECURRENCE FREE SURVIVAL; SEROMA; WOUND INFECTION;

ADULT; AGED; AGED, 80 AND OVER; CONFIDENCE INTERVALS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; QUEENSLAND; RADIOTHERAPY, ADJUVANT; RISK ASSESSMENT; SINGLE-BLIND METHOD; SKIN NEOPLASMS; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; WATCHFUL WAITING; YOUNG ADULT;

EID: 84861574744     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(12)70138-9     Document Type: Article

References (30)

1. Byers RM The role of modified neck dissection in the treatment of cutaneous melanoma of the head and neck. Arch Surg 1986, 121:1338-1341.
2. Balch CM, Soong SJ, Murad TM, Ingalls AL, Maddox WA A multifactorial analysis of melanoma III: prognostic factors in melanoma patients with lymph node metastases. Ann Surg 1983, 193:377-388.
3. Karakousis CP, Seddig MK, Moore R Prognostic value of lymph node dissection in malignant melanoma. Arch Surg 1980, 115:719-722.
4. Burmeister BH, Smithers BM, Poulsen M, et al. Radiation therapy for nodal disease in malignant melanoma. World J Surg 1995, 19:369-371.
5. O'Brien CJ, Petersen-Schaefer K, Stevens GN, et al. Adjuvant radiotherapy following neck dissection and parotidectomy for metastatic melanoma. Head Neck 1997, 19:589-594.
6. Corry J, Smith JG, Bishop M, Ainslie J Nodal radiation therapy for metastatic melanoma. Int J Radiat Oncol Biol Phys 1999, 44:1065-1069.
7. Stevens G, Thompson JF, Firth I, et al. Locally advanced melanoma: results of postoperative hypofractionated radiation therapy. Cancer 2000, 88:88-94.
8. Ballo MT, Strom EA, Zagars GK, et al. Adjuvant irradiation for axillary metastases from malignant melanoma. Int J Radiat Oncol Biol Phys 2002, 52:964-972.
9. Ballo MT, Bonnen MD, Garden AS, et al. Adjuvant irradiation for cervical lymph node metastases from melanoma. Cancer 2003, 97:1789-1796.
10. Ballo MT, Zagars GK, Gershenwald JE, et al. A critical assessment of adjuvant radiotherapy for inguinal lymph node metastases from melanoma. Ann Surg Oncol 2004, 11:1079-1084.
11. Ballo MT, Ross MI, Cormier JN, et al. Combined modality therapy for patients with regional nodal metastases from melanoma. Int J Radiat Oncol Biol Phys 2006, 64:106-113.
12. Hamming-Vrieze O, Balm AJ, Heemsbergen WD, et al. Regional control of melanoma neck node metastasis after selective neck dissection with or without adjuvant radiotherapy. Arch Otolaryngol Head Neck Surg 2009, 135:795-800.
13. Conill C, Valduvieco I, Domingo-Domenech J, et al. Loco-regional control after postoperative radiotherapy for patients with regional nodal metastases from melanoma. Clin Transl Oncol 2009, 11:688-693.
14. Agrawal S, Kane JM, Guadagnolo BA, et al. The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node metastatic melanoma. Cancer 2009, 115:5836-5844.
15. Strojan P, Jancar B, Cemazar M, et al. Melanoma metastases to neck nodes: role of adjuvant radiation. Int J Radiat Oncol Biol Phys 2010, 77:1039-1045.
16. Bibault JE, Dewas S, Mirabel X, et al. Adjuvant radiation therapy in metastatic lymph nodes from melanoma. Radiat Oncol 2011, 6:12.
17. Burmeister BH, Smithers BM, Burmeister E, et al. A prospective phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma-Trans Tasman Radiation Oncology Group (TROG) Study 96.06. Radiother Oncol 2006, 81:136-142.
18. Burmeister BH, Smithers BM, Davis S, et al. Radiation therapy following nodal surgery for melanoma: an analysis of late toxicity. ANZ J Surg 2002, 72:344-348.
19. Cox JD, Stetz J, Pajak TF Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Rad Oncol Biol 1995, 31:1341-1346.
20. Creagan ET, Cupps RE, Ivins JC, et al. Adjuvant radiation therapy for regional nodal metastases from malignant melanoma: a randomized prospective study. Cancer 1978, 42:2206-2210.
21. Guadagnolo BA, Zagars GK Adjuvant radiation therapy for high-risk nodal metastases from cutaneous melanoma. Lancet Oncol 2009, 10:409-416.
22. Bastiaannet E, Beukema JC, Hoekstra HJ, et al. Radiation therapy following lymph node dissection in melanoma patients: treatment, outcome and complications. Cancer Treat Rev 2005, 31:18-26.
23. Shen P, Wanek LA, Morton DL Is adjuvant radiotherapy necessary after positive lymph node dissection in head and neck melanomas?. Ann Surg Oncol 2000, 7:554-559.
24. Fuhrmann D, Lippold A, Borrosch F, et al. Should adjuvant radiotherapy be recommended following resection of regional lymph node metastases of malignant melanomas?. Br J Dermatol 2001, 144:66-70.
25. Miller EJ, Daly JM, Synnestfedt M, et al. Loco-regional relapse in melanoma. Surg Oncol 1992, 1:333-340.
26. Gadd MA, Coit DG Recurrence patterns and outcomes in 1019 patients undergoing axillary or inguinal lymphadenectomy for melanoma. Arch Surg 1992, 127:1412-1416.
27. Calabro A, Singletary SE, Balch CM Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg 1989, 124:1051-1055.
28. Overgaard J The role of radiotherapy in recurrent and metastatic malignant melanoma: a clinical radiobiological study. Int J Rad Oncol Biol Phys 1986, 12:867-872.
29. Stevens G, McKay MJ Dispelling the myths surrounding radiation therapy for treatment of cutaneous melanoma. Lancet Oncol 2006, 7:575-583.
30. Kruijff S, Bastiaannet E, Speijers MJ, et al. The value of pre-operative S-100B and SUV in clinically stage III melanoma patients undergoing therapeutic lymph node dissection. Eur J Surg Oncol 2011, 37:225-232.