EcPV-2 is transcriptionally active in equine SCC but only rarely detectable in swabs and semen from healthy horses

Veterinary Microbiology

Volumn 158, Issue 1-2, 2012, Pages 194-198

  Sykora, Sabine ^a   Samek, Lisa ^a   Schönthaler, Katharina ^a   Palm, Franziska ^a   Borzacchiello, Giuseppe ^b   Aurich, Christine ^a   Brandt, Sabine ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

DNA; EcPV 2; Horse; Milk; MRNA; Papillomavirus; SCC; Semen; Swabs

Indexed keywords

GLYCOPROTEIN E1; MESSENGER RNA; PROTEIN E6; PROTEIN E7; VIRUS DNA; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; DNA SEQUENCE; EQUUS CABALLUS PAPILLOMAVIRUS 2; FEMALE; HORSE; MALE; MILK; NONHUMAN; PAPILLOMA VIRUS; PENIS CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERM; SQUAMOUS CELL CARCINOMA; VIRUS CULTURE; VULVA CARCINOMA;

ANIMALS; CARCINOMA, SQUAMOUS CELL; EYE NEOPLASMS; HORSE DISEASES; HORSES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SEMEN; TRANSCRIPTION, GENETIC; UROGENITAL NEOPLASMS;

EQUIDAE; EQUUS CABALLUS; PAPILLOMAVIRIDAE;

EID: 84861570774     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2012.02.006     Document Type: Article

References (18)

1. Brandt S., Haralambus R., Schoster A., Kirnbauer R., Stanek C. Peripheral blood mononuclear cells represent a reservoir of bovine papillomavirus DNA in sarcoid-affected equines. J. Gen. Virol. 2008, 89:1390-1395.
2. Chow L.T., Broker T.R. Mechanisms and regulation of papillomavirus DNA replication. Papillomavirus Research: From Natural History to Vaccines and Beyond 2006, 53-71. Caister Academic Press, Norfolk. M.S. Campo (Ed.).
3. Dayyani F., Etzel C.J., Liu M., Ho C.H., Lippman S.M., Tsao A.S. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol. 2010, 2:15.
4. Gardiol D., Kühne C., Glaunsinger B., Lee S.S., Javier R., Banks L. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene 1999, 18:5487-5496.
5. Javier R.T. Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene 2008, 27(55):7031-7046.
6. Kainzbauer C., Rushton J., Tober R., Scase T., Nell B., Sykora S., Brandt S. Bovine papillomavirus type 1 and Equus caballus papillomavirus 2 in equine squamous cell carcinoma of the head and neck in a Connemara mare. Equine Vet. J. 2011, 10.1111/j.2042-3306.2010.00358.x.
7. Knight C.G., Munday J.S., Peters J., Dunowska M. Equine penile squamous cell carcinomas are associated with the presence of equine papillomavirus type 2 DNA sequences. Vet. Pathol. 2011, PMID: 21282669.
8. Kohrgruber N., Gröger M., Meraner P., Kriehuber E., Petzelbauer P., Brandt S., Stingl G., Rot A., Maurer D. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol. 2004, 173:6592-6602.
9. Lange C.E., Tobler K., Markau T., Alhaidari Z., Bornand V., Stöckli R., Trüssel M., Ackermann M., Favrot C. Sequence and classification of FdPV2, a papillomavirus isolated from feline Bowenoid in situ carcinomas. Vet. Microbiol. 2009, 137:60-65.
10. Munday J.S., Kiupel M. Papillomavirus-associated cutaneous neoplasia in mammals. Vet. Pathol. 2010, 47:254-264.
11. Scase T., Brandt S., Kainzbauer C., Sykora S., Bijmholt S., Hughes K., Sharpe S., Foote A. Equus caballus papillomavirus-2 (EcPV-2): an infectious cause for equine genital cancer?. Equine Vet. J. 2010, 42:738-745.
12. Scott D.W., Miller W.H. Squamous cell carcinoma. Equine Dermatology 2003, 707-712. Elsevier Science, St. Louis, Missouri, USA. Saunders (Ed.).
13. Sundberg J.P., Burnstein T., Page E.H., Kirkham W.W., Robinson F.R. Neoplasms of Equidae. J. Am. Vet. Med. Assoc. 1977, 170:150-152.
14. Thomas M., Pim D., Banks L. The role of the HPV E6 oncoprotein in malignant progression. Papillomavirus Research: From Natural History to Vaccines and Beyond 2006, 115-131. Caister Academic Press, Norfolk. M.S. Campo (Ed.).
15. Yuan H., Ghim S., Newsome J., Apolinario T., Olcese V., Martin M., Delius H., Felsburg P., Jenson B., Schlegel R. An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Virology 2007, 359:28-36.
16. Zaugg N., Nespeca G., Hauser B., Ackermann M., Favrot C. Detection of novel papillomaviruses in canine mucosal, cutaneous and in situ squamous cell carcinomas. Vet. Dermatol. 2005, 16:290-298.
17. Zur Hausen H. Papillomavirus infections-a major cause of human cancers. Biochim. Biophys. Acta 1996, 1288:F55-F78.
18. Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer. Inst. 2000, 92:690-698. (Review).