B lymphocytes provide an infection niche for intracellular bacterium brucella abortus

Journal of Infectious Diseases

Volumn 206, Issue 1, 2012, Pages 91-98

  Goenka, Radhika ^a,b   Guirnalda, Patrick D ^a,b   Black, Samuel J ^a   Baldwin, Cynthia L ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN; IMMUNOGLOBULIN M; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BACTERIAL COUNT; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; COLONY FORMING UNIT; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE TRANSMISSION; ENDOSOME; FLOW CYTOMETRY; HOST CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INFECTION NICHE; INTRACELLULAR BACTERIUM; LYSOSOME; MICROBIOLOGICAL PARAMETERS; MICROFILAMENT; MICROSCOPY; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS ENTRY;

ANIMALS; ANTIBODIES, BACTERIAL; B-LYMPHOCYTES; BRUCELLA ABORTUS; BRUCELLOSIS; COMPLEMENT SYSTEM PROTEINS; DNA REPLICATION; ENDOSOMES; IMMUNOGLOBULIN M; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED BALB C; MONOCYTES; PHAGOCYTOSIS; STEM CELLS; SURVIVAL; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84861564549     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis310     Document Type: Article

References (34)

1. Celli J, de Chastellier C, Franchini DM, Pizarro-Cerda J, Moreno E, Gorvel JP. Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J Exp Med 2003; 198:545-56.
2. Billard E, Cazevieille C, Dornand J, Gross A. High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis. Infect Immun 2005; 73:8418-24.
3. Anderson TD, Cheville NF. Ultrastructural morphometric analysis of Brucella abortus-infected trophoblasts in experimental placentitis. Bacterial replication occurs in rough endoplasmic reticulum. Am J Pathol 1986; 124:226-37.
4. Jiang X, Baldwin CL. Effects of cytokines on intracellular growth of Brucella abortus. Infect Immun 1993; 61:124-34.
5. Bellaire BH, Roop RM 2nd, Cardelli JA. Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytes. Infect Immun 2005; 73:3702-13.
6. O'Callaghan D, Cazevieille C, Allardet-Servent A, et al. A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis. Mol Microbiol 1999; 33:1210-20.
7. Hong PC, Tsolis RM, Ficht TA. Identification of genes required for chronic persistence of Brucella abortus in mice. Infect Immun 2000; 68:4102-7.
8. Baldwin CL, Goenka R. Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection? Crit Rev Immunol 2006; 26:407-42.
9. Goenka R, Parent MA, Elzer PH, Baldwin CL. B cell-deficient mice display markedly enhanced resistance to the intracellular bacterium Brucella abortus. J Infect Dis 2011; 203:1136-46.
10. Mizoguchi A, Bhan AK. A case for regulatory B cells. J Immunol 2006; 176:705-10.
11. Shibuya A, Sakamoto N, Shimizu Y, et al. Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 2000; 1:441-6.
12. Bosio CM, Gardner D, Elkins KL. Infection of B cell-deficient mice with CDC 1551, a clinical isolate of Mycobacterium tuberculosis: delay in dissemination and development of lung pathology. J Immunol 2000; 164:6417-25.
13. Lombardi G, del Gallo F, Vismara D, et al. Epstein-Barr virustransformed B cells process and present Mycobacterium tuberculosis particulate antigens to T-cell clones. Cell Immunol 1987; 107:281-92.
14. Vidard L, Kovacsovics-Bankowski M, Kraeft SK, Chen LB, Benacerraf BRock KL. Analysis of MHC class II presentation of particulate antigens of B lymphocytes. J Immunol 1996; 156:2809-18.
15. Murphy E, Robertson GT, Parent M, et al. Major histocompatibility complex class I and II expression on macrophages containing a virulent strain of Brucella abortus measured using green fluorescent protein-expressing brucellae and flow cytometry. FEMS Immunol Med Microbiol 2002; 33:191-200.
16. Newman SL, Mikus LK, Tucci MA. Differential requirements for cellular cytoskeleton in human macrophage complement receptor-and Fc receptor-mediated phagocytosis. J Immunol 1991; 146:967-74.
17. Chen J, Trounstine M, Alt FW, et al. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol 1993; 5:647-56.
18. Elzer PH, Jacobson RH, Jones SM, Nielsen KH, Douglas JT, Winter AJ. Antibody-mediated protection against Brucella abortus in BALB/c mice at successive periods after infection: variation between virulent strain 2308 and attenuated vaccine strain 19. Immunology 1994; 82:651-8.
19. Bjornson AB, Detmers PA. The pentameric structure of IgM is necessary to enhance opsonization of Bacteroides thetaiotaomicron and Bacteroides fragilis via the alternative complement pathway. Microb Pathog 1995; 19:117-28.
20. Parent MA, Goenka R, Murphy E, et al. Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain. Microbes Infect 2007; 9:55-62.
21. Starr T, Ng TW, Wehrly TD, Knodler LA, Celli J. Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartment. Traffic 2008; 9:678-94.
22. Pesando JM, Bouchard LS, McMaster BE. CD19 is functionally and physically associated with surface immunoglobulin. J Exp Med 1989; 170:2159-64.
23. Bermudez LE, Covaro G, Remington J. Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors. Infect Immun 1993; 61:4126-30.
24. Barral A, Barral-Netto M, Yong EC, Brownell CE, Twardzik DR, Reed SG. Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proc Natl Acad Sci USA 1993; 90:3442-6.
25. Porte F, Liautard JP, Kohler S. Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages. Infect Immun 1999; 67:4041-7.
26. Boschiroli ML, Ouahrani-Bettache S, Foulongne V, et al. The Brucella suis virB operon is induced intracellularly in macrophages. Proc Natl Acad Sci USA 2002; 99:1544-9.
27. Rolan HG, Xavier MN, Santos RL, Tsolis RM. Natural antibody contributes to host defense against an attenuated Brucella abortus virB mutant. Infect Immun 2009; 77:3004-13.
28. Honda S, Kurita N, Miyamoto A, et al. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci USA 2009; 106:11230-5.
29. Betts M, Beining P, Brunswick M, et al. Lipopolysaccharide from Brucella abortus behaves as a T-cell-independent type 1 carrier in murine antigen-specific antibody responses. Infect Immun 1993; 61:1722-9.
30. Martin F, Oliver AM, Kearney JF. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 2001; 14:617-29.
31. Spera JM, Ugalde JE, Mucci J, Comerci DJ, Ugalde RA. A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection. Proc Natl Acad Sci USA 2006; 103:16514-9.
32. Johnson BA 3rd, Kahler DJ, Baban B, et al. B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci USA 2010; 107:10644-8.
33. Conlan JW, North RJ. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J Exp Med 1991; 174:741-4.
34. Labrec EH, Schneider H, Magnani TJ, Formal SB. Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J Bacteriol 1964; 88:1503-18.