Assessing actual contribution of IF1, inhibitor of mitochondrial F oF1, to ATP homeostasis, cell growth, mitochondrial morphology, and cell viability

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 18781-18787

  Fujikawa, Makoto ^a,b   Imamura, Hiromi ^c   Nakamura, Junji ^a   Yoshida, Masasuke ^a,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; ATP HYDROLYSIS; ATP LEVEL; ATP SYNTHASE; ATP SYNTHESIS; ATP-HYDROLYSIS ACTIVITY; CELL INJURY; CELL VIABILITY; CONTROL-CELL; ENERGY METABOLISM; GLUCOSE CONSUMPTION; HELA CELL; HIGH CONCENTRATION; MITOCHONDRIAL MORPHOLOGY; MITOCHONDRIAL PROTEIN; OPTIMUM GROWTH CONDITIONS; PROTON-MOTIVE FORCES; REACTIVE OXYGEN SPECIES;

CELL GROWTH; ECOLOGY; GLUCOSE; GROWTH KINETICS; HYDROLYSIS; MITOCHONDRIA; MORPHOLOGY; OXYGEN; PHYSIOLOGY; PROTONS;

CYTOLOGY;

ADENOSINE TRIPHOSPHATASE INHIBITORY FACTOR 1; ADENOSINE TRIPHOSPHATE; GLUCOSE; MITOCHONDRIAL PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL DEATH; CELL GROWTH; CELL LEVEL; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME INHIBITION; GLUCOSE INTAKE; GLYCOLYSIS; GROWTH RATE; HELA CELL; HOMEOSTASIS; HYDROLYSIS; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTON MOTIVE FORCE;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE KNOCKDOWN TECHNIQUES; HOMEOSTASIS; PROKARYOTIC INITIATION FACTOR-2; PROTON-TRANSLOCATING ATPASES;

EID: 84861562196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.345793     Document Type: Article

References (28)

1. Pullman, M. E., and Monroy, G. C. (1963) A naturally occurring inhibitor of mitochondrial adenosine triphosphatase. J. Biol. Chem. 238, 3762-3769
2. Ichikawa, N., Ushida, S., Kawabata, M., and Masazumi, Y. (1999) Nucleotide sequence of cDNA coding the mitochondrial precursor protein of the ATPase inhibitor from humans. Biosci. Biotechnol. Biochem. 63, 2225-2227 (Pubitemid 129549053)
3. Ichikawa, N., Yoshida, Y., Hashimoto, T., Ogasawara, N., Yoshikawa, H., Imamoto, F., and Tagawa, K. (1990) Activation of ATP hydrolysis by an uncoupler in mutant mitochondria lacking an intrinsic ATPase inhibitor in yeast. J. Biol. Chem. 265, 6274-6278
4. Yamada, E., Ishiguro, N., Miyaishi, O., Takeuchi, A., Nakashima, I., Iwata, H., and Isobe, K. (1997) Differential display analysis of murine collagen-induced arthritis: Cloning of the cDNA-encoding murine ATPase inhibitor. Immunology 92, 571-576 (Pubitemid 27525231)
5. o-ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. J. Biol. Chem. 277, 33906-33912
6. 1-ATPase inhibitor protein, IF1, by pH. J. Biol. Chem. 275, 25460-25464
7. Cabezón, E., Montgomery, M. G., Leslie, A. G., and Walker, J. E. (2003) The structure of bovine F1-ATPase in complex with its regulatory protein IF1. Nat. Struct. Biol. 10, 744-750 (Pubitemid 37052414)
8. +-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype. J. Biol. Chem. 285, 25308-25313
9. o-ATPase inhibitor protein, IF1. Cell Metab. 8, 13-25
10. Buzhynskyy, N., Sens, P., Prima, V., Sturgis, J. N., and Scheuring, S. (2007) Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophys. J. 93, 2870-2876 (Pubitemid 47607823)
11. o-ATP synthase. Biochemistry 45, 12695-12703
12. Strauss, M., Hofhaus, G., Schröder, R. R., and Kühlbrandt, W. (2008) Dimer ribbons of ATP synthase shape the inner mitochondrial membrane. EMBO J. 27, 1154-1160 (Pubitemid 351508145)
13. o-ATP synthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy. Biochim. Biophys. Acta 1787, 393-401
14. De los Rios Castillo, D., Zarco-Zavala, M., Olvera-Sanchez, S., Pardo, J. P., Juarez, O., Martinez, F., Mendoza-Hernandez, G., García-Trejo, J. J., and Flores-Herrera, O. (2011) Atypical cristae morphology of human syncytiotrophoblast mitochondria: Role for complex V. J. Biol. Chem. 286, 23911-23919
15. Giraud, M. F., Paumard, P., Soubannier, V., Vaillier, J., Arselin, G., Salin, B., Schaeffer, J., Brèthes, D., di Rago, J. P., and Velours, J. (2002) Is there a relationship between the supramolecular organization of the mitochondrial ATP synthase and the formation of cristae? Biochim. Biophys. Acta 1555, 174-180 (Pubitemid 35246024)
16. o bridging features and the structural basis of mitochondrial cristae biogenesis. Proc. Natl. Acad. Sci. U.S.A. 102, 12356-12358
17. Paumard, P., Vaillier, J., Coulary, B., Schaeffer, J., Soubannier, V., Mueller, D. M., Brèthes, D., di Rago, J. P., and Velours, J. (2002) The ATP synthase is involved in generating mitochondrial cristae morphology. EMBO J. 21, 221-230 (Pubitemid 34137284)
18. Wittig, I., Meyer, B., Heide, H., Steger, M., Bleier, L., Wumaier, Z., Karas, M., and Schägger, H. (2010) Assembly and oligomerization of human ATP synthase lacking mitochondrial subunits a and A6L. Biochim. Biophys. Acta 1797, 1004-1011
19. o-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J. Biol. Chem. 277, 39289-39295
20. o-ATP synthase from bovine heart is independent from the binding of the inhibitor protein IF1. Biochim. Biophys. Acta 1556, 133-141
21. Pallotti, F., and Lenaz, G. (2007) Isolation and subfractionation of mitochondria from animal cells and tissue culture lines. Methods Cell Biol. 80, 3-44
22. Fujikawa, M., and Yoshida, M. (2010) A sensitive, simple assay of mitochondrial ATP synthesis of cultured mammalian cells suitable for high-throughput analysis. Biochem. Biophys. Res. Commun. 401, 538-543
23. Ohsakaya, S., Fujikawa, M., Hisabori, T., and Yoshida, M. (2011) Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria. J. Biol. Chem. 286, 20292-20296
24. Dubois, M., Gilles, K., Hamilton, J. K., Rebers, P. A., and Smith, F. (1951) A colorimetric method for the determination of sugars. Nature 168, 167
25. Imamura, H., Huynh Nhat, K., Togawa, H., Saito, K., Iino, R., Kato-Yamada, Y., Nagai, T., and Noji, H. (2009) Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc. Natl. Acad. Sci. U.S.A. 106, 15651-15656
26. Lu, Y. M., Miyazawa, K., Yamaguchi, K., Nowaki, K., Iwatsuki, H., Wakamatsu, Y., Ichikawa, N., and Hashimoto, T. (2001) Deletion of mitochondrial ATPase inhibitor in the yeast Saccharomyces cerevisiae decreased cellular and mitochondrial ATP levels under non-nutritional conditions and induced a respiration-deficient cell-type. J. Biochem. 130, 873-878 (Pubitemid 34024139)
27. Wittig, I., and Schägger, H. (2008) Structural organization of mitochondrial ATP synthase. Biochim. Biophys. Acta 1777, 592-598
28. Mansour, T. E., and Ahlfors, C. E. (1968) Studies on heart phosphofructokinase. Some kinetic and physical properties of the crystalline enzyme. J. Biol. Chem. 243, 2523-2533