Interferon dysregulation and virusinduced cell death in avian influenza H5N1 virus infections

Hong Kong Medical Journal

Volumn 18, Issue SUPP2, 2012, Pages 12-16

  Lee, D C W ^a   Law, A H Y ^a   Hui, K ^a   Tam, A H M ^a   Peiris, J S M ^a   Lau, A S Y ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON; INTERFERON REGULATORY FACTOR 3; LAMBDA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CASPASE 3; CYTOKINE; IL29 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; IRF3 PROTEIN, HUMAN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; APOPTOSIS; BIOSYNTHESIS; CELL CULTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLUENZA; INFLUENZA VIRUS A H1N1; METABOLISM; UPREGULATION; VIROLOGY;

APOPTOSIS; CASPASE 3; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; INTERLEUKINS; MACROPHAGES; POLY(ADP-RIBOSE) POLYMERASES; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84861557680     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. World Health Organization avian influenza information. Available at: http://www.who.int/csr/disease/avian_influenza/en/.
2. Guan Y, Shortridge KF, Krauss S, Webster RG. Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong? Proc Natl Acad Sci USA 1999;96:9363-7.
3. Lee DC, Cheung CY, Law AH, Mok CK, Peiris M, Lau AS. p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. J Virol 2005;79:10147-54.
4. Hui KP, Lee SM, Cheung CY, et al. Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J Immunol 2009;182:1088-98.
5. Mok CK, Lee DC, Cheung CY, Peiris M, Lau AS. Differential onset of apoptosis in influenza A virus H5N1-and H1N1-infected human blood macrophages. J Gen Virol 2007;88:1275-80.