Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease

Heart

Volumn 98, Issue 12, 2012, Pages 926-933

  Grandi, Norma Christine ^a   Brenner, Hermann ^a   Hahmann, Harry ^b   Wüsten, Bernd ^c   März, Winfried ^d   Rothenbacher, Dietrich ^a   Breitling, Lutz Philipp ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Klinik Schwabenland   (Germany)

^c Klinik Am Südpark   (Germany)

^d SYNLAB ACADEMY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CALCIUM; PHOSPHATE;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; CALCIUM BLOOD LEVEL; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INCIDENCE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROGNOSIS; REHABILITATION CARE; STABLE CORONARY HEART DISEASE;

ADULT; AGED; BIOLOGICAL MARKERS; CALCIUM; CAUSE OF DEATH; CORONARY DISEASE; FEMALE; FOLLOW-UP STUDIES; GERMANY; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PHOSPHATES; POPULATION SURVEILLANCE; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 84861529521     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2011-300806     Document Type: Article

References (44)

1. Bergwitz C, Jüppner H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF-23. Annu Rev Med 2010;61:91-104.
2. Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol 2004;15:2959-64. (Pubitemid 39578826)
3. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006;99:1044-59. (Pubitemid 44729928)
4. Jorde R, Sundsfjord J, Bonaa KH. Determinants of serum calcium in men and women. The Tromso Study. Eur J Epidemiol 2001;17:1117-23.
5. Lind L, Jakobsson S, Lithell H, et al. Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease. BMJ 1988;297:960-3.
6. Williams DM, Fraser A, Lawlor DA. Associations of vitamin D, parathyroid hormone and calcium with cardiovascular risk factors in US adolescents. Heart 2011;97:315-20.
7. de Boer IH, Rue TC, Kestenbaum B. Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis 2009;53:399-407.
8. Lippi G, Montagnana M, Salvagno GL, et al. Relationship between serum phosphate and cardiovascular risk factors in a large cohort of adult outpatients. Diabetes Res Clin Pract 2009;84:e3-5.
9. Onufrak SJ, Bellasi A, Cardarelli F, et al. Investigation of gender heterogeneity in the associations of serum phosphorus with incident coronary artery disease and all-cause mortality. Am J Epidemiol 2009;169:67-77.
10. Grandi NC, Breitling LP, Brenner H. Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Prev Med 2010;51:228-33.
11. Hagström E, Hellman P, Larsson TE, et al. Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation 2009;119:2765-71.
12. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch Intern Med 2008;168:1340-9. (Pubitemid 351930842)
13. Grandi NC, Breitling LP, Hahmann H, et al. Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease. Heart 2011;97:1215-21.
14. Dhingra R, Sullivan LM, Fox CS, et al. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 2007;167:879-85. (Pubitemid 46762749)
15. Foley RN, Collins AJ, Ishani A, et al. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2008;156:556-63.
16. Larsson TE, Olauson H, Hagstrom E, et al. Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community. Arterioscler Thromb Vasc Biol 2010;30:333-9.
17. Leifsson BG, Ahren B. Serum calcium and survival in a large health screening program. J Clin Endocrinol Metab 1996;81:2149-53. (Pubitemid 26175940)
18. Lind L, Skarfors E, Berglund L, et al. Serum calcium: a new, independent, prospective risk factor for myocardial infarction in middle-aged men followed for 18 years. J Clin Epidemiol 1997;50:967-73. (Pubitemid 27423528)
19. Slinin Y, Blackwell T, Ishani A, et al. Serum calcium, phosphorus and cardiovascular events in post-menopausal women. Int J Cardiol 2011;149:335-40.
20. Tonelli M, Sacks F, Pfeffer M, et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005;112:2627-33. (Pubitemid 41532599)
21. Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341: c3691.
22. Koenig W, Twardella D, Brenner H, et al. Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin Chem 2005;51:321-7. (Pubitemid 40175801)
23. Rothenbacher D, Koenig W, Brenner H. Comparison of N-terminal pro-B-natriuretic peptide, C-reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease. Arch Intern Med 2006;166:2455-60. (Pubitemid 44913229)
24. von Eynatten M, Hamann A, Twardella D, et al. Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease. Eur Heart J 2008;29:1307-15. (Pubitemid 351768129)
25. Grandi NC, Breitling LP, Vossen CY, et al. Serum vitamin D and risk of secondary cardiovascular disease events in patients with stable coronary heart disease. Am Heart J 2010;159:1044-51.
26. Bjorkman MP, Sorva AJ, Tilvis RS. Calculated serum calcium is an insufficient surrogate for measured ionized calcium. Arch Gerontol Geriatr 2009;49:348-50.
27. White TF, Farndon JR, Conceicao SC, et al. Serum calcium status in health and disease: a comparison of measured and derived parameters. Clin Chim Acta 1986;157:199-213. (Pubitemid 16084910)
28. Payne RB, Little AJ, Williams RB, et al. Interpretation of serum calcium in patients with abnormal serum proteins. BMJ 1973;4:643-6.
29. Heinzl H, Kaider A. Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions. Comput Methods Programs Biomed 1997;54:201-8. (Pubitemid 27496007)
30. Sato Y, Kuno H, Asoh T, et al. Effect of immobilization on vitamin D status and bone mass in chronically hospitalized disabled stroke patients. Age Ageing 1999;28:265-9. (Pubitemid 29229329)
31. Wermers RA, Kearns AE, Jenkins GD, et al. Incidence and clinical spectrum of thiazide-associated hypercalcemia. Am J Med 2007;120:911.e9-15.
32. Ljunghall S, Hedstrand H, Hellsing K, et al. Calcium, phosphate and albumin in serum. A population study with special reference to renal stone formers and the prevalence of hyperparathyroidism in middle-aged men. Acta Med Scand 1977;201:23-30. (Pubitemid 8027092)
33. Orrell DH. Albumin as an aid to the interpretation of serum calcium. Clin Chim Acta 1971;35:483-9.
34. Fried LP, Kronmal RA, Newman AB, et al. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA 1998;279:585-92.
35. Phillips A, Shaper AG, Whincup PH. Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes. Lancet 1989;2:1434-6. (Pubitemid 20012066)
36. Ogard CG, Petersen J, Jorgensen T, et al. Serum ionised calcium and cardiovascular disease in 45-year old men and women followed for 18 years. Eur J Epidemiol 2006;21:123-7. (Pubitemid 43341200)
37. Almquist M, Bondeson AG, Bondeson L, et al. Serum levels of vitamin D, PTH and calcium and breast cancer risk - a prospective nested case-control study. Int J Cancer 2010;127:2159-68.
38. Skinner HG, Schwartz GG. A prospective study of total and ionized serum calcium and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 2009;18:575-8.
39. Yang H, Curinga G, Giachelli CM. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int 2004;66:2293-9. (Pubitemid 41115292)
40. Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol 2010;(Suppl 1):S23-30.
41. Grande G. Genderspezifische Aspekte der Gesundheitsversorgung und Rehabilitation nach Herzinfarkt. Gender-specific aspects in health care delivery and rehabilitation after an acute myocardial infarction. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2008;51:36-45.
42. Suaya JA, Shepard DS, Normand SL, et al. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007;116:1653-62. (Pubitemid 47537840)
43. Martin TJ, Grill V. Hypercalcemia in cancer. J Steroid Biochem Mol Biol 1992;41:123-9.
44. Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract 2007;22:286-96.