Association study of a new schizophrenia susceptibility locus of 10q24.32-33 in a Han Chinese population

Schizophrenia Research

Volumn 138, Issue 1, 2012, Pages 63-68

  Guan, Fanglin ^a   Wei, Shuguang ^b   Feng, Jiali ^b   Zhang, Chen ^c   Xing, Bo ^d   Zhang, Hongbo ^a   Gao, Chengge ^b   Yang, Huanming ^e   Li, Shengbin ^f  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^d SHANDONG MENTAL HEALTH CENTER   (China)

^e BGI SHENZHEN   (China)

^f Institute of Human Genomics and Forensic Sciences   (China)

Author keywords

10q24.32 33; Association study; Han chinese; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CHINESE; CHROMOSOME 10Q; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 84861528006     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.03.030     Document Type: Article

References (30)

1. Andreasen N.C. Symptoms, signs, and diagnosis of schizophrenia. Lancet 1995, 346(8973):477-481.
2. Bailer U., Leisch F., Meszaros K., Lenzinger E., Willinger U., Strobl R., Gebhardt C., Gerhard E., Fuchs K., Sieghart W., Kasper S., Hornik K., Aschauer H.N. Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology 2000, 42(4):175-182.
3. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265.
4. Curtis D., Xu K. Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics. BMC Genet. 2007, 8:38.
5. Curtis D., Knight J., Sham P.C. Program report: GENECOUNTING support programs. Ann. Hum. Genet. 2006, 70(Pt 2):277-279.
6. Fallin M.D., Lasseter V.K., Wolyniec P.S., McGrath J.A., Nestadt G., Valle D., Liang K.Y., Pulver A.E. Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22. Am. J. Hum. Genet. 2003, 73(3):601-611.
7. Harrison P.J., Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 2005, 10(1):40-68. image45.
8. Korostishevsky M., Kaganovich M., Cholostoy A., Ashkenazi M., Ratner Y., Dahary D., Bernstein J., Bening-Abu-Shach U., Ben-Asher E., Lancet D., Ritsner M., Navon R. Is the G72/G30 locus associated with schizophrenia? Single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol. Psychiatry 2004, 56(3):169-176.
9. Lai J.H., Zhu Y.S., Huo Z.H., Sun R.F., Yu B., Wang Y.P., Chai Z.Q., Li S.B. Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction. Brain Res. 2010, 1359:227-232.
10. Lerer B., Segman R.H., Hamdan A., Kanyas K., Karni O., Kohn Y., Korner M., Lanktree M., Kaadan M., Turetsky N., Yakir A., Kerem B., Macciardi F. Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol. Psychiatry 2003, 8(5):488-498.
11. Levinson D.F., Mahtani M.M., Nancarrow D.J., Brown D.M., Kruglyak L., Kirby A., Hayward N.K., Crowe R.R., Andreasen N.C., Black D.W., Silverman J.M., Endicott J., Sharpe L., Mohs R.C., Siever L.J., Walters M.K., Lennon D.P., Jones H.L., Nertney D.A., Daly M.J., Gladis M., Mowry B.J. Genome scan of schizophrenia. Am. J. Psychiatry 1998, 155(6):741-750.
12. Lewis C.M., Levinson D.F., Wise L.H., DeLisi L.E., Straub R.E., Hovatta I., Williams N.M., Schwab S.G., Pulver A.E., Faraone S.V., Brzustowicz L.M., Kaufmann C.A., Garver D.L., Gurling H.M., Lindholm E., Coon H., Moises H.W., Byerley W., Shaw S.H., Mesen A., Sherrington R., O'Neill F.A., Walsh D., Kendler K.S., Ekelund J., Paunio T., Lonnqvist J., Peltonen L., O'Donovan M.C., Owen M.J., Wildenauer D.B., Maier W., Nestadt G., Blouin J.L., Antonarakis S.E., Mowry B.J., Silverman J.M., Crowe R.R., Cloninger C.R., Tsuang M.T., Malaspina D., Harkavy-Friedman J.M., Svrakic D.M., Bassett A.S., Holcomb J., Kalsi G., McQuillin A., Brynjolfson J., Sigmundsson T., Petursson H., Jazin E., Zoega T., Helgason T. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am. J. Hum. Genet. 2003, 73(1):34-48.
13. Menashe I., Rosenberg P.S., Chen B.E. PGA: power calculator for case-control genetic association analyses. BMC Genet. 2008, 9:36.
14. Mowry B.J., Ewen K.R., Nancarrow D.J., Lennon D.P., Nertney D.A., Jones H.L., O'Brien M.S., Thornley C.E., Walters M.K., Crowe R.R., Silverman J.M., Endicott J., Sharpe L., Hayward N.K., Gladis M.M., Foote S.J., Levinson D.F. Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample. Am. J. Med. Genet. 2000, 96(6):864-869.
15. Mueser K.T., McGurk S.R. Schizophrenia. Lancet 2004, 363(9426):2063-2072.
16. O'Donovan M.C., Craddock N., Norton N., Williams H., Peirce T., Moskvina V., Nikolov I., Hamshere M., Carroll L., Georgieva L., Dwyer S., Holmans P., Marchini J.L., Spencer C.C., Howie B., Leung H.T., Hartmann A.M., Moller H.J., Morris D.W., Shi Y., Feng G., Hoffmann P., Propping P., Vasilescu C., Maier W., Rietschel M., Zammit S., Schumacher J., Quinn E.M., Schulze T.G., Williams N.M., Giegling I., Iwata N., Ikeda M., Darvasi A., Shifman S., He L., Duan J., Sanders A.R., Levinson D.F., Gejman P.V., Cichon S., Nothen M.M., Gill M., Corvin A., Rujescu D., Kirov G., Owen M.J., Buccola N.G., Mowry B.J., Freedman R., Amin F., Black D.W., Silverman J.M., Byerley W.F., Cloninger C.R. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 2008, 40(9):1053-1055.
17. Ripke S., Sanders A.R., Kendler K.S., Levinson D.F., Sklar P., Holmans P.A., Lin D.Y., Duan J., Ophoff R.A., Andreassen O.A., Scolnick E., Cichon S., St Clair D., Corvin A., Gurling H., Werge T., Rujescu D., Blackwood D.H., Pato C.N., Malhotra A.K., Purcell S., Dudbridge F., Neale B.M., Rossin L., Visscher P.M., Posthuma D., Ruderfer D.M., Fanous A., Stefansson H., Steinberg S., Mowry B.J., Golimbet V., De Hert M., Jonsson E.G., Bitter I., Pietilainen O.P., Collier D.A., Tosato S., Agartz I., Albus M., Alexander M., Amdur R.L., Amin F., Bass N., Bergen S.E., Black D.W., Borglum A.D., Brown M.A., Bruggeman R., Buccola N.G., Byerley W.F., Cahn W., Cantor R.M., Carr V.J., Catts S.V., Choudhury K., Cloninger C.R., Cormican P., Craddock N., Danoy P.A., Datta S., de Haan L., Demontis D., Dikeos D., Djurovic S., Donnelly P., Donohoe G., Duong L., Dwyer S., Fink-Jensen A., Freedman R., Freimer N.B., Friedl M., Georgieva L., Giegling I., Gill M., Glenthoj B., Godard S., Hamshere M., Hansen M., Hansen T., Hartmann A.M., Henskens F.A., Hougaard D.M., Hultman C.M., Ingason A., Jablensky A.V., Jakobsen K.D., Jay M., Jurgens G., Kahn R.S., Keller M.C., Kenis G., Kenny E., Kim Y., Kirov G.K., Konnerth H., Konte B., Krabbendam L., Krasucki R., Lasseter V.K., Laurent C., Lawrence J., Lencz T., Lerer F.B., Liang K.Y., Lichtenstein P., Lieberman J.A., Linszen D.H., Lonnqvist J., Loughland C.M., Maclean A.W., Maher B.S., Maier W., Mallet J., Malloy P., Mattheisen M., Mattingsdal M., McGhee K.A., McGrath J.J., McIntosh A., McLean D.E., McQuillin A., Melle I., Michie P.T., Milanova V., Morris D.W., Mors O., Mortensen P.B., Moskvina V., Muglia P., Myin-Germeys I., Nertney D.A., Nestadt G., Nielsen J., Nikolov I., Nordentoft M., Norton N., Nothen M.M., O'Dushlaine C.T., Olincy A., Olsen L., O'Neill F.A., Orntoft T.F., Owen M.J., Pantelis C., Papadimitriou G., Pato M.T., Peltonen L., Petursson H., Pickard B., Pimm J., Pulver A.E., Puri V., Quested D., Quinn E.M., Rasmussen H.B., Rethelyi J.M., Ribble R., Rietschel M., Riley B.P., Ruggeri M., Schall U., Schulze T.G., Schwab S.G., Scott R.J., Shi J., Sigurdsson E., Silverman J.M., Spencer C.C., Stefansson K., Strange A., Strengman E., Stroup T.S., Suvisaari J., Terenius L., Thirumalai S., Thygesen J.H., Timm S., Toncheva D., van den Oord E., van Os J., van Winkel R., Veldink J., Walsh D., Wang A.G., Wiersma D., Wildenauer D.B., Williams H.J., Williams N.M., Wormley B., Zammit S., Sullivan P.F., O'Donovan M.C., Daly M.J., Gejman P.V. Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 2011, 43(10):969-976.
18. Ross C.A., Margolis R.L., Reading S.A., Pletnikov M., Coyle J.T. Neurobiology of schizophrenia. Neuron 2006, 52(1):139-153.
19. Rousset F., Raymond M. Testing heterozygote excess and deficiency. Genetics 1995, 140(4):1413-1419.
20. Schaid D.J., Rowland C.M., Tines D.E., Jacobson R.M., Poland G.A. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet. 2002, 70(2):425-434.
21. Sham P.C., Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 1995, 59(Pt 1):97-105.
22. Shi Y., Li Z., Xu Q., Wang T., Li T., Shen J., Zhang F., Chen J., Zhou G., Ji W., Li B., Xu Y., Liu D., Wang P., Yang P., Liu B., Sun W., Wan C., Qin S., He G., Steinberg S., Cichon S., Werge T., Sigurdsson E., Tosato S., Palotie A., Nothen M.M., Rietschel M., Ophoff R.A., Collier D.A., Rujescu D., Clair D.S., Stefansson H., Stefansson K., Ji J., Wang Q., Li W., Zheng L., Zhang H., Feng G., He L. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat. Genet. 2011, 43(12):1224-1227.
23. Venken T., Alaerts M., Souery D., Goossens D., Sluijs S., Navon R., Van Broeckhoven C., Mendlewicz J., Del-Favero J., Claes S. Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families. Mol. Psychiatry 2008, 13(4):442-450.
24. Wei Y.L., Li C.X., Li S.B., Liu Y., Hu L. Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese. Behav. Brain Funct. 2011, 7:42.
25. Williams N.M., Rees M.I., Holmans P., Norton N., Cardno A.G., Jones L.A., Murphy K.C., Sanders R.D., McCarthy G., Gray M.Y., Fenton I., McGuffin P., Owen M.J. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Hum. Mol. Genet. 1999, 8(9):1729-1739.
26. Yue W.H., Wang H.F., Sun L.D., Tang F.L., Liu Z.H., Zhang H.X., Li W.Q., Zhang Y.L., Zhang Y., Ma C.C., Du B., Wang L.F., Ren Y.Q., Yang Y.F., Hu X.F., Wang Y., Deng W., Tan L.W., Tan Y.L., Chen Q., Xu G.M., Yang G.G., Zuo X.B., Yan H., Ruan Y.Y., Lu T.L., Han X., Ma X.H., Cai L.W., Jin C., Zhang H.Y., Yan J., Mi W.F., Yin X.Y., Ma W.B., Liu Q., Kang L., Sun W., Pan C.Y., Shuang M., Yang F.D., Wang C.Y., Yang J.L., Li K.Q., Ma X., Li L.J., Yu X., Li Q.Z., Huang X., Lv L.X., Li T., Zhao G.P., Huang W., Zhang X.J., Zhang D. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat. Genet. 2011, 43(12):1228-1231.
27. Zhao J.H. 2LD, GENECOUNTING and HAP: computer programs for linkage disequilibrium analysis. Bioinformatics 2004, 20(8):1325-1326.
28. Zhao J.H., Sham P.C. Generic number systems and haplotype analysis. Comput. Methods Programs Biomed. 2003, 70(1):1-9.
29. Zhao J.H., Curtis D., Sham P.C. Model-free analysis and permutation tests for allelic associations. Hum. Hered. 2000, 50(2):133-139.
30. Zhao J.H., Lissarrague S., Essioux L., Sham P.C. GENECOUNTING: haplotype analysis with missing genotypes. Bioinformatics 2002, 18(12):1694-1695.