Potential of melatonin for the treatment or prevention of obesity: An urgent need to include weight reduction as a secondary outcome in clinical trials of melatonin in obese patients with sleep disorders

Contemporary Clinical Trials

Volumn 33, Issue 4, 2012, Pages 574-575

  Rastmanesh, Reza ^a,b,c   de Bruin, Pedro Felipe C ^d  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b National Nutrition and Food Technology Research Institute Tehran   (Iran)

^c Faculty of Nutrition and Food Industry   (Iran)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Melatonin; Obesity; Sleep disorder; Treatment

Indexed keywords

MELATONIN;

APPETITE; BODY WEIGHT; CLINICAL TRIAL; COMORBIDITY; DRUG EFFICACY; FOOD INTAKE; HUMAN; LETTER; OBESITY; QUESTIONNAIRE; SLEEP DISORDER; TREATMENT OUTCOME; WEIGHT REDUCTION;

CENTRAL NERVOUS SYSTEM DEPRESSANTS; CLINICAL TRIALS AS TOPIC; HUMANS; MELATONIN; OBESITY; SLEEP DISORDERS; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84861527313     PISSN: 15517144     EISSN: 15592030     Source Type: Journal    
DOI: 10.1016/j.cct.2012.03.018     Document Type: Letter

References (26)

1. Beitins I.Z., Barkan A., Klibanski A., Kyung N., Reppert S.M., Badger T.M., et al. Hormonal responses to short term fasting in postmenopausal women. J Clin Endocrinol Metab 1985, 60:1120-1126.
2. Birketvedt G.S., Florholmen J., Sundsfjord J., Osterud B., Dinges D., Bilker W., et al. Behavioral and neuroendocrine characteristics of the night-eating syndrome. JAMA 8-18-1999, 282:657-663.
3. Ferrari E., Foppa S., Bossolo P.A., Comis S., Esposti G., Licini V., et al. Melatonin and pituitary-gonadal function in disorders of eating behavior. J Pineal Res 1989, 7:115-124.
4. Ferrari E., Magri F., Pontiggia B., Rondanelli M., Fioravanti M., Solerte S.B., et al. Circadian neuroendocrine functions in disorders of eating behavior. Eat Weight Disord 1997, 2:196-202.
5. Gunduz B. Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus). Comp Biochem Physiol A Mol Integr Physiol 2002, 132:393-401.
6. Ostrowska Z., Zwirska-Korczala K., Buntner B., Pardela M., Drozdz M. Association of body mass and body fat distribution with serum melatonin levels in obese women either non-operated or after jejunoileostomy. Endocr Regul 1996, 30:33-40.
7. Qin L.Q., Li J., Wang Y., Wang J., Xu J.Y., Kaneko T. The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sci 9-26-2003, 73:2467-2475.
8. Raskind M.A., Burke B.L., Crites N.J., Tapp A.M., Rasmussen D.D. Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats. Neuropsychopharmacology 2007, 32:284-288.
9. Rios-Lugo M.J., Cano P., Jimenez-Ortega V., Fernandez-Mateos M.P., Scacchi P.A., Cardinali D.P., et al. Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat-fed rats. J Pineal Res 2010, 49:342-348.
10. Rojdmark S., Berg A., Rossner S., Wetterberg L. Nocturnal melatonin secretion in thyroid disease and in obesity. Clin Endocrinol (Oxf) 1991, 35:61-65.
11. Shafii M., MacMillan D.R., Key M.P., Kaufman N., Nahinsky I.D. Case study: melatonin in severe obesity. J Am Acad Child Adolesc Psychiatry 1997, 36:412-416.
12. Tamarkin L., Abastillas P., Chen H.C., McNemar A., Sidbury J.B. The daily profile of plasma melatonin in obese and Prader-Willi syndrome children. J Clin Endocrinol Metab 1982, 55:491-495.
13. Willig R.P., Braun W., Commentz J.C., Stahnke N. Circadian fluctuation of plasma melatonin in Prader-Willi's syndrome and obesity. Acta Endocrinol Suppl (Copenh) 1986, 279:411-415.
14. Pandi-Perumal S.R., Srinivasan V., Maestroni G.J., Cardinali D.P., Poeggeler B., Hardeland R. Melatonin: nature's most versatile biological signal?. FEBS J 2006, 273:2813-2838.
15. Bartness T.J., Wade G.N. Photoperiodic control of seasonal body weight cycles in hamsters. Neurosci Biobehav Rev 1985, 9:599-612.
16. van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., Drossaerts J.M., Kemerink G.J., Bouvy N.D., et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 4-9-2009, 360:1500-1508.
17. Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., et al. Functional brown adipose tissue in healthy adults. N Engl J Med 4-9-2009, 360:1518-1525.
18. Tan D.X., Manchester L.C., Fuentes-Broto L., Paredes S.D., Reiter R.J. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev 2011, 12:167-188.
19. Ciortea R., Costin N., Braicu I., Haragas D., Hudacsko A., Bondor C., et al. Effect of melatonin on intra-abdominal fat in correlation with endometrial proliferation in ovariectomized rats. Anticancer Res 2011, 31:2637-2643.
20. Lee S.K., Sirajudeen K.N., Sundaram A., Zakaria R., Singh H.J. Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats. J Physiol Biochem 2011, 67:249-257.
21. Montano M.E., Molpeceres V., Mauriz J.L., Garzo E., Cruz I.B., Gonzalez P., et al. Effect of melatonin supplementation on food and water intake in streptozotocin-diabetic and non-diabetic male Wistar rats. Nutr Hosp 2010, 25:931-938.
22. Rao M.V., Purohit A., Patel T. Melatonin protection on mercury-exerted brain toxicity in the rat. Drug Chem Toxicol 2010, 33:209-216.
23. Buscemi N., Vandermeer B., Hooton N., Pandya R., Tjosvold L., Hartling L., et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2-18-2006, 332:385-393.
24. Nachtigal M.C., Patterson R.E., Stratton K.L., Adams L.A., Shattuck A.L., White E. Dietary supplements and weight control in a middle-age population. J Altern Complement Med 2005, 11:909-915.
25. Cardinali D.P., Cano P., Jimenez-Ortega V., Esquifino A.I. Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications. Neuroendocrinology 2011, 93:133-142.
26. Reiter R.J., Tan D.X., Korkmaz A., Ma S. Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. Ann Med 6-13-2011, 10.3109/07853890.2011.586365.