Pharmacokinetic analysis of absorption, distribution and disappearance of ingested water labeled with D2O in humans

European Journal of Applied Physiology

Volumn 112, Issue 6, 2012, Pages 2213-2222

  Péronnet, François ^a   Mignault, Diane ^a,b   Du Souich, Patrick ^a   Vergne, Sébastien ^c   Bellego, Laurent Le ^c   Jimenez, Liliana ^c   Rabasa Lhoret, Rémi ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c DANONE RESEARCH   (France)

Author keywords

Absorption rate; Body water pool; Elimination rate; Hydrogen isotopes; Water clearance; Water turnover

Indexed keywords

DEUTERIUM OXIDE; WATER;

ABSORPTION; ADULT; ARTICLE; BODY FLUID; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; KINETICS; MALE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; TISSUE DISTRIBUTION;

ABSORPTION; ADULT; BODY FLUIDS; DEUTERIUM OXIDE; HUMANS; KINETICS; MALE; TISSUE DISTRIBUTION; WATER;

EID: 84861526315     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2194-7     Document Type: Article

References (42)

1. Armstrong LE, Klau JF, Ganio MS, McDermott BP, Yeargin SW, Lee EC, Maresh CM (2010) Accumulation of 2H2O in plasma and eccrine sweat during exercise-heat stress. Eur J Appl Physiol 108: 477-482
2. Bacic G, Alameda JC Jr, Iannone A, Magin RL, Swartz HM (1989) NMR study of water exchange across the hepatocyte membrane. Magn Reson Imaging 7: 411-416 (Pubitemid 20021971)
3. Bering EA Jr (1952) Water exchange of central nervous system and cerebrospinal fluid. J Neurosurg 9: 275-287
4. Blanc S, Normand S, Ritz P, Pachiaudi C, Vico L, Gharib C, Gauquelin-Koch G (1998) Energy and water metabolism, body composition, and hormonal changes induced by 42 days of enforced inactivity and simulated weightlessness. J Clin Endocrinol Metab 83: 4289-4297 (Pubitemid 29100124)
5. Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16: 31-41
6. Colley RC, Byrne NM, Hills AP (2007) Implications of the variability in time to isotopic equilibrium in the deuterium dilution technique. Eur J Clin Nutr 61: 1250-1255 (Pubitemid 350048206)
7. Currell K, Urch J, Cerri E, Jentjens RL, Blannin AK, Jeukendrup AE (2008) Plasma deuterium oxide accumulation following ingestion of different carbohydrate beverages. Appl Physiol Nutr Metab 33: 1067-1072
8. Davies S, Spanel P, Smith D (2001) Rapid measurement of deuterium content of breath following oral ingestion to determine body water. Physiol Meas 22: 651-659 (Pubitemid 33104652)
9. Davis JM, Lamb DR, Burgess WA, Bartoli WP (1987) Accumulation of deuterium oxide in body fluids after ingestion of D2O-labeled beverages. J Appl Physiol 63: 2060-2066 (Pubitemid 18016439)
10. Davis JM, Burgess WA, Slentz CA, Bartoli WP (1990) Fluid availability of sports drinks differing in carbohydrate type and concentration. Am J Clin Nutr 51: 1054-1057
11. Edelman IS (1952) Exchange of water between blood and tissues; characteristics of deuterium oxide equilibration in body water. Am J Physiol 171: 279-296
12. EFSA Panel on Dietetic Products N, and Allergies (NDA) (2010) Scientific opinion on dietary reference values for water. EFSA J8: 48
13. Fabry ME, Eisenstadt M (1975) Water exchange between red cells and plasma. Measurement by nuclear magnetic relaxation. Biophys J 15: 1101-1110
14. Hahn L, Hevesy G (1940) Rate of penetration of ions through the capillary wall. Acta Physiol Scand 1: 347-361
15. Hill RJ, Bluck LJ, Davies PS (2008) The hydration ability of three commercially available sports drinks and water. J Sci Med Sport 11: 116-123 (Pubitemid 351249229)
16. Horita J, Kendall C (2004) Stable isotope analysis of water and aqueous solutions by conventional dual-inlet mass spectrometry. Handbook of stable isotope analytical techniques, vol 1. Elsevier, New-York, pp 1-37
17. Koulmann N, Melin B, Jimenez C, Charpenet A, Savourey G, Bittel J(1997) Effects of different carbohydrate-electrolyte beverages on the appearance of ingested deuterium in body fluids during moderate exercise by humans in the heat. Eur J Appl Physiol Occup Physiol 75: 525-531 (Pubitemid 27280967)
18. Lambert GP, Chang RT, Xia T, Summers RW, Gisolfi CV (1997) Absorption from different intestinal segments during exercise. J Appl Physiol 83: 204-212 (Pubitemid 27304751)
19. Lee PR, Code CF, Scholer JF (1955) The influence of varying concentrations of sodium chloride on the rate of absorption of water from the stomach and small bowel of human beings. Gastroenterology 29: 1008-1016
20. Leiper JB, Carnie A, Maughan RJ (1996) Water turnover rates in sedentary and exercising middle aged men. Br J Sports Med 30: 24-26 (Pubitemid 26088217)
21. Love AH, Mitchell TG, Phillips RA (1968) Water and sodium absorption in the human intestine. J Physiol 195: 133-140
22. Maguire RP, Spyrou NM, Leenders KL (2003) Whole body [O-15] water pharmacokinetics measured in blood. Physiol Meas 24: 237-249 (Pubitemid 36648392)
23. Mendez J, Prokop E, Picon-Reategui E, Akers R, Buskirk ER (1970) Total body water by D2O dilution using saliva samples and gas chromatography. J Appl Physiol 28: 354-357
24. Murray R, Eddy DE, Bartoli WP, Paul GL (1994) Gastric emptying of water and isocaloric carbohydrate solutions consumed at rest. Med Sci Sports Exerc 26: 725-732 (Pubitemid 24172352)
25. Oppliger RA, Magnes SA, Popowski LA, Gisolfi CV (2005) Accuracy of urine specific gravity and osmolality as indicators of hydration status. Int J Sport Nutr Exerc Metab 15: 236-251 (Pubitemid 40904987)
26. Palma R, Vidon N, Bernier JJ (1981) Maximal capacity for fluid absorption in human bowel. Dig Dis Sci 26: 6
27. Pappenheimer JR (1953) Passage of molecules through capillary walls. Physiol Rev 33: 387-423
28. Pinson EA, Langham WH (1957) Physiology and toxicology of tritium in man. J Appl Physiol 10: 108-126
29. Racette SB, Schoeller DA, Luke AH, Shay K, Hnilicka J, Kushner RF (1994) Relative dilution spaces of 2H- and 18O-labeled water in humans. Am J Physiol 267: E585-E590
30. Raman A, Schoeller DA, Subar AF, Troiano RP, Schatzkin A, Harris T, Bauer D, Bingham SA, Everhart JE, Newman AB, Tylavsky FA (2004) Water turnover in 458 American adults 40-79 yr of age. Am J Physiol Renal Physiol 286: F394-F401 (Pubitemid 38141685)
31. Schloerb PR, Friis-Hansen BJ, Edelman IS, Solomon AK, Moore FD (1950) The measurement of total body water in the human subject by deuterium oxide dilution; with a consideration of the dynamics of deuterium distribution. J Clin Invest 29: 1296-1310
32. Schoeller DA, van Santen E, Peterson DW, Dietz W, Jaspan J, Klein PD (1980) Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr 33: 2686-2693 (Pubitemid 11172011)
33. Schoeller DA, Leitch CA, Brown C (1986a) Doubly labeled water method: in vivo oxygen and hydrogen isotope fractionation. Am J Physiol 251: R1137-R1143
34. Schoeller DA, Ravussin E, Schutz Y, Acheson KJ, Baertschi P, Jequier E (1986b) Energy expenditure by doubly labeled water: validation in humans and proposed calculation. Am J Physiol 250: R823-R830
35. Scholer JF (1962) Determination of rates of absorption in the blood by integration of rates of appearance and disappearance. Am JDig Dis 7: 43-49
36. Scholer JF, Code CF (1954) Rate of absorption of water from stomach and small bowel of human beings. Gastroenterology 27: 565-583
37. Schwartz PL (1966) Exchange of blood water in normal tissues and mammary carcinomas in mice. Am J Physiol 211: 173-176
38. van Marken Lichtenbelt WD, Westerterp KR, Wouters L (1994) Deuterium dilution as a method for determining total body water: effect of test protocol and sampling time. Br J Nutr 72: 491-497 (Pubitemid 24317357)
39. Verkman AS, Wong KR (1987) Proton nuclear magnetic resonance measurement of diffusional water permeability in suspended renal proximal tubules. Biophys J 51: 717-723
40. Wang Z, Deurenberg P, Wang W, Pietrobelli A, Baumgartner RN, Heymsfield SB (1999) Hydration of fat-free body mass: review and critique of a classic body-composition constant. Am J Clin Nutr 69: 833-841 (Pubitemid 29205055)
41. Westerterp KR, Wouters L, van Marken Lichtenbelt WD (1995) The Maastricht protocol for the measurement of body composition and energy expenditure with labeled water. Obes Res 3(Suppl 1): 49-57
42. Wong WW, Cochran WJ, Klish WJ, Smith EO, Lee LS, Klein PD (1988) In vivo isotope-fractionation factors and the measurement of deuterium- and oxygen-18-dilution spaces from plasma, urine, saliva, respiratory water vapor, and carbon dioxide. Am J Clin Nutr 47: 1-6 (Pubitemid 18091530)