Elevated hematocrit in nonalcoholic fatty liver disease: A potential cause for the increased risk of cardiovascular disease?

Clinical Hemorheology and Microcirculation

Volumn 51, Issue 1, 2012, Pages 59-68

  Li, Guolin ^a   Li, Ye ^a   Liu, Li ^a   Chen, Yaqin ^a   Hu, Xiaofei ^a   Wang, Jun ^a   Gao, Jun ^a   Yin, Dazhong ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

Author keywords

cardiovascular disease; hematocrit; Nonalcoholic fatty liver disease (NAFLD)

Indexed keywords

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIET; DISEASE ASSOCIATION; FEMALE; HEMATOCRIT; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NONALCOHOLIC FATTY LIVER; PHYSICAL ACTIVITY; PHYSICAL EXAMINATION; QUESTIONNAIRE; SLEEP QUALITY; TOBACCO;

ADULT; ALCOHOL DRINKING; CARDIOVASCULAR DISEASES; FATTY LIVER; FEMALE; HEMATOCRIT; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; RISK; RISK FACTORS; SMOKING;

EID: 84861521499     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-2011-1509     Document Type: Article

References (49)

1. M. Acikel, S. Sunay, M. Koplay, F. Gundogdu and S. Karakelleoglu, Evaluation of ultrasonographic fatty liver and severity of coronary atherosclerosis, and obesity in patients undergoing coronary angiography, Anadolu Kardiyol Derg 9 (2009), 273-279.
2. P. Angulo, Nonalcoholic fatty liver disease, New England Journal of Medicine 346 (2002), 1221-1231.
3. I. A. Baker, J. Pickering, P. C. Elwood, A. Bayer and S. Ebrahim, Fibrinogen, viscosity and white blood cell count predict myocardial, but not cerebral infarction: Evidence from the Caerphilly and Speedwell cohort, Thrombosis and Haemostasis 87 (2002), 421-425. (Pubitemid 34232482)
4. O. K. Baskurt, M. Boynard, G. C. Cokelet, P. Connes, B. M. Cooke, S. Forconi, F. Liao, M. R. Hardeman, F. Jung, H. J. Meiselman, G. Nash, N. Nemeth, B. Neu, B. Sandhagen, S. Shin, G. Thurston and J. L. Wautier, New guidelines for hemorheological laboratory techniques, Clinical Hemorheology and Microcirculation 42 (2009), 75-97.
5. A. S. Bowers, D. J. Pepple and H. L. Reid, Optimal haematocrit in subjects with normal haemoglobin genotype (HbAA), sickle cell trait (HbAS), and homozygous sickle cell disease (HbSS), Clinical Hemorheology and Microcirculation 47 (2011), 253-260.
6. J. D. Browning, L. S. Szczepaniak, R. Dobbins, P. Nuremberg, J. D. Horton, J. C. Cohen, S. M. Grundy and H. H. Hobbs, Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity, Hepatology 40 (2004), 1387-1395. (Pubitemid 39657013)
7. J. F. Brun, C. Bouchahda, D. Chaze, A. A. Benhaddad, J. P. Micallef and J. Mercier, The paradox of hematocrit in exercise physiology: Which is the "normal" range from an hemorheologist's viewpoint? Clinical Hemorheology and Microcircu-lation 22 (2000), 287-303.
8. S. Chien, S. Usami, H. M. Taylor, J. L. Lundberg and M. I. Gregersen, Effects of hematocrit and plasma proteins on human blood rheology at low shear rates, Journal of Applied Physiology 21 (1966), 81-87.
9. E. Crisa, E. Venturino, R. Passera, M. Prina, P. Schinco, A. Borchiellini, V. Giai, M. A. Ciocca Vasino, M. Bazzan, A. Vaccarino, M. Boccadoro and D. Ferrero, A retrospective study on 226 polycythemia vera patients: Impact of median hematocrit value on clinical outcomes and survival improvement with anti-thrombotic prophylaxis and non-alkylating drugs, Annals of Hematology 89 (2010), 691-699.
10. N. M. de Alwis and C. P. Day, Non-alcoholic fatty liver disease: The mist gradually clears, Journal of Hepatology 48(Suppl 1) (2008), S104-S112.
11. D. M. Eckmann, S. Bowers, M. Stecker and A. T. Cheung, Hematocrit, volume expander, temperature, and shear rate effects on blood viscosity, Anesthesia and Analgesia 91 (2000), 539-545.
12. M. Ekstedt, L. E. Franzen, U. L. Mathiesen, L. Thorelius, M. Holmqvist, G. Bodemar andS. Kechagias, Long-term follow-up of patients with NAFLD and elevated liver enzymes, Hepatology 44 (2006), 865-873. (Pubitemid 46489550)
13. Ethical. guidelines for publication in clinical hemorheology and microcirculation, Clinical Hemorheology and Microcir-culation 44 (2010), 1-2.
14. J. G. Fan and G. C. Farrell, Epidemiology of non-alcoholic fatty liver disease in China, Journal of Hepatology 50 (2009), 204-210.
15. S. Goland, S. Shimoni, T. Zornitzki, H. Knobler, O. Azoulai, G. Lutaty, E. Melzer, A. Orr, A. Caspi and S. Malnick, Cardiac abnormalities as a new manifestation of nonalcoholic fatty liver disease: Echocardiographic and tissue Doppler imaging assessment, Journal of Clinical Gastroenterology 40 (2006), 949-955. (Pubitemid 44690772)
16. F. Grubbs, Procedures for detecting outlying observations in samples, Technometrics 11 (1969), 1-21.
17. M. Hamaguchi, T. Kojima, N. Takeda, C. Nagata, J. Takeda, H. Sarui, Y. Kawahito, N. Yoshida, A. Suetsugu, T. Kato, J. Okuda, K. Ida and T. Yoshikawa, Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease, World journal of gastroenterology 13 (2007), 1579-1584. (Pubitemid 46672668)
18. D. W. Hosmer and S. Lemeshow, Applied logistic regression. 2nd ed., Wiley, New York, 2000.
19. F. Jung, Fromhemorheology to microcirculation and regenerative medicine:Fahraeus Lecture 2009, Clinical Hemorheology and Microcirculation 45 (2010), 79-99.
20. H. Kiesewetter, F. Jung, S. Spitzer and E. Wenzel, (The flow properties of blood and their clinical significance in the arterial vascular patient), Internist (Berl) 30 (1989), 420-428.
21. W. Koenig, M. Sund, H. Lowel, A. Doring and E. Ernst, Association between plasma viscosity and all-cause mortality: Results from the MONICA-Augsburg Cohort Study 1984-92, British Journal of Haematology 109 (2000), 453-458. (Pubitemid 30350734)
22. A. J. Lee, P. I. Mowbray, G. D. Lowe, A. Rumley, F. G. Fowkes and P. L. Allan, Blood viscosity and elevated carotid intima-media thickness in men and women: The Edinburgh Artery Study, Circulation 97 (1998), 1467-1473. (Pubitemid 28191302)
23. G. Li, L. Liu, H. Hu, Q. Zhao, F. Xie, K. Chen, S. Liu, Y. Chen, W. Shi and D. Yin, Age-related carbonyl stress and erythrocyte membrane protein carbonylation, Clinical Hemorheology and Microcirculation 46 (2010), 305-311.
24. S. Liu, W. Shi, G. Li, B. Jin, Y. Chen, H. Hu, L. Liu, F. Xie, K. Chen and D. Yin, Plasma reactive carbonyl species levels and risk of nonalcoholic fatty liver disease, Journal of Gastroenterology and Hepatology 26 (2011), 1010-1015.
25. E. P. Lopes, L. H. Sette, J. B. Sette, C. F. Luna, A. M. Andrade, M. Moraes, P. C. Sette, R. Menezes, R. L. Cavalcanti and S. C. Conceicao, Serum alanine aminotransferase levels, hematocrit rate and body weight correlations before and after hemodialysis session, Clinics (Sao Paulo) 64 (2009), 941-945.
26. G. Loute, D. Pieters, J. P. Jadot, A. Bosly and M. Moriau, Effect of the variation of hematocrit on the proteinuria of a patient with polycythemia and congenital heart disease, Nephron 46 (1987), 109-111.
27. G. Lowe, A. Rumley, J. Norrie, I. Ford, J. Shepherd, S. Cobbe, P. Macfarlane and C. Packard, Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study, Thrombosis and Haemostasis 84 (2000), 553-558.
28. C. A. Matteoni, Z. M. Younossi, T. Gramlich, N. Boparai, Y. C. Liu and A. J. McCullough, Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity, Gastroenterology 116 (1999), 1413-1419. (Pubitemid 29258890)
29. G. Miao, Y. Yan, Z. Chuanmin and L. Naiying, Discussion on the relationship between normal hematocrit and geographical factors in China, Clinical Hemorheology and Microcirculation 17 (1997), 459-465. (Pubitemid 28092757)
30. S. M. Moghimi and H. M. Patel, Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition, Journal of Controlled Release 78 (2002), 55-65. (Pubitemid 34081853)
31. V. Nobili, A. Alisi and M. Raponi, Pediatric non-alcoholic fatty liver disease: Preventive and therapeutic value of lifestyle intervention, World journal of gastroenterology 15 (2009), 6017-6022.
32. G. Nollert, J. Sperling, T. Sakamoto, B. R. Jaeger and R. A. Jonas, Higher hematocrit improves liver blood flow and metabolism during cardiopulmonary bypass in piglets, Thoracic and Cardiovascular Surgeon 49 (2001), 226-230. (Pubitemid 32776893)
33. A. G. Olsson, M. Blomback and L. G. Ekelund, The relation between plasma fibrinogen, blood hematocrit and exercise ST segment depressions in hyperlipoproteinemia, Artery 7 (1980), 215-223. (Pubitemid 11253130)
34. M. X. Richardson, R. de Bruijn and E. Schagatay, Hypoxia augments apnea-induced increase in hemoglobin concentration and hematocrit, European Journal of Applied Physiology and Occupational Physiology 105 (2009), 63-68.
35. M. J. Schindl, A. M. Millar, D. N. Redhead, K. C. Fearon, J. A. Ross, C. H. Dejong, O. J. Garden and S. J. Wigmore, The adaptive response of the reticuloendothelial system to major liver resection in humans, Annals of Surgery 243 (2006), 507-514.
36. B. Schuler, M. Arras, S. Keller, A. Rettich, C. Lundby, J. Vogel andM. Gassmann, Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice, Proceedings of the National Academy of Sciences of the United States of America 107 (2010), 419-423.
37. J. Shibata, J. Hasegawa, H. J. Siemens, E. Wolber, L. Dibbelt, D. Li, D. M. Katschinski, J. Fandrey, W. Jelkmann, M. Gassmann, R. H. Wenger and K. F. Wagner, Hemostasis and coagulation at a hematocrit level of 0. 85: Functional consequences of erythrocytosis, Blood 101 (2003), 4416-4422. (Pubitemid 36857807)
38. S. Steiner, T. Jax, S. Evers, M. Hennersdorf, A. Schwalen and B. E. Strauer, Altered blood rheology in obstructive sleep apnea as a mediator of cardiovascular risk, Cardiology 104 (2005), 92-96. (Pubitemid 41197018)
39. G. Targher, L. Bertolini, R. Padovani, S. Rodella, G. Zoppini, L. Zenari, M. Cigolini, G. Falezza and G. Arcaro, Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease, Diabetes Care 29 (2006), 1325-1330. (Pubitemid 44125930)
40. G. Targher, L. Bertolini, S. Rodella, R. Tessari, L. Zenari, G. Lippi and G. Arcaro, Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients, Diabetes Care 30 (2007), 2119-2121. (Pubitemid 47219432)
41. G. Targher, F. Marra and G. Marchesini, Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: Causal effect or epiphenomenon? Diab tologia 51 (2008), 1947-1953.
42. D. G. Tiniakos, M. B. Vos and E. M. Brunt, Nonalcoholic fatty liver disease: Pathology and pathogenesis, Annual Review of Pathology 5 (2010), 145-171.
43. K. Tominaga, J. H. Kurata, Y. K. Chen, E. Fujimoto, S. Miyagawa, I. Abe and Y. Kusano, Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey, Digestive Diseases and Sciences 40 (1995), 2002-2009.
44. J. Tripette, M. D. Hardy-Dessources, E. Beltan, A. Sanouiller, J. Bangou, T. Chalabi, R. Chout, M. Hedreville, C. Broquere, D. Nebor, G. Dotzis, O. Hue and P. Connes, Endurance running trial in tropical environment: A blood rheological study, Clinical Hemorheology and Microcirculation 47 (2011), 261-268.
45. M. L. Turgeon, Principles of blood collection, In: Clinical hematology: Theory and procedures, M. L. Turgeon, ed. Lippincott Williams & Wilkins, Philadelphia, 2004, pp. 18-40.
46. L. F. Van Gaal, I. L. Mertens and C. E. De Block, Mechanisms linking obesity with cardiovascular disease, Nature 444 (2006), 875-880. (Pubitemid 46028447)
47. N. Villanova, S. Moscatiello, S. Ramilli, E. Bugianesi, D. Magalotti, E. Vanni, M. Zoli and G. Marchesini, Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease, Hepatology 42 (2005), 473-480. (Pubitemid 41061101)
48. M. D. Zeng, J. G. Fan, L. G. Lu, Y. M. Li, C. W. Chen, B. Y. Wang and Y. M. Mao, Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases, J Dig Dis 9 (2008), 108-112. (Pubitemid 351566633)
49. M. H. Zweig and G. Campbell, Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine, Clinical Chemistry 39 (1993), 561-577. (Pubitemid 23118304)