In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: A cohort study

Critical Care Medicine

Volumn 40, Issue 6, 2012, Pages 1835-1843

  Koh, Gavin C K W ^a,b,c,d   Vlaar, Alexander P J ^a   Hofstra, Jorrit J ^a   De Jong, H Katrien ^a   Van Nierop, Samuel ^e   Peacock, Sharon J ^b,c   Wiersinga, W Joost ^a   Schultz, Marcus J ^a   Juffermans, Nicole P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b MAHIDOL UNIVERSITY   (Thailand)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

acute lung injury; acute respiratory distress syndrome; confounding factors (epidemiology); Cox regression; diabetes mellitus; heart failure; hydroxymethylglutaryl CoA reductase inhibitors; intensive care; mortality; multinomial logistic regression

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; METFORMIN; SULFONYLUREA DERIVATIVE;

ACUTE LUNG INJURY; ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CRITICALLY ILL PATIENT; DIABETES MELLITUS; FEMALE; HEART STRESS; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL;

ACUTE LUNG INJURY; AGED; CARDIAC VOLUME; CRITICAL ILLNESS; DIABETES COMPLICATIONS; DIABETES MELLITUS; FEMALE; HOSPITAL MORTALITY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84861512324     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31824e1696     Document Type: Article

References (36)

1. World Health Organization: Fact sheet no. 312: Diabetes. 2011
2. Brown JR, Edwards FH, O'Connor GT, et al: The diabetic disadvantage: Historical outcomes measures in diabetic patients undergoing cardiac surgery-the pre-intravenous insulin era. Semin Thorac Cardiovasc Surg 2006; 18:281-288
3. Stegenga ME, Vincent JL, Vail GM, et al: Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med 2010; 38:539-545
4. Slynkova K, Mannino DM, Martin GS, et al: The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohort. Crit Care 2006; 10:R137
5. Esper AM, Moss M, Martin GS: The effect of diabetes mellitus on organ dysfunction with sepsis: An epidemiological study. Crit Care 2009; 13:R18
6. Graham BB, Keniston A, Gajic O, et al: Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med 2010; 38:16-24
7. Koh GC, Maude RR, Schreiber MF, et al: Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis. Clin Infect Dis 2011; 52:717-725
8. Pittet D, Thiévent B, Wenzel RP, et al: Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med 1993; 19:265-272
9. Vincent JL, Preiser JC, Sprung CL, et al: Insulin-treated diabetes is not associated with increased mortality in critically ill patients. Crit Care 2010; 14:R12
10. Dahagam CK, Mora A, Wolf SE, et al: Diabetes does not influence selected clinical outcomes in critically ill burn patients. J Burn Care Res 2011; 32:256-262
11. MacCallum NS, Evans TW: Epidemiology of acute lung injury. Curr Opin Crit Care 2005; 11:43-49
12. Gong MN, Thompson BT, Williams P, et al: Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion. Crit Care Med 2005; 33:1191-1198
13. Moss M, Guidot DM, Steinberg KP, et al: Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med 2000; 28:2187-2192
14. Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med 2000; 342:1334-1349
15. Honiden S, Gong MN: Diabetes, insulin, and development of acute lung injury. Crit Care Med 2009; 37:2455-2464
16. Janda S, Young A, Fitzgerald JM, et al: The effect of statins on mortality from severe infections and sepsis: A systematic review and meta-analysis. J Crit Care 2010; 25:656.e7-656.22
17. Thomsen RW, Hundborg HH, Johnsen SP,et al: Statin use and mortality within 180 days after bacteremia: A population-based cohort study. Crit Care Med 2006; 34:1080-1086
18. O'Neal HR Jr, Koyama T, Koehler EA, et al: Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med 2011; 39:1343-1350
19. Hagiwara S, Iwasaka H, Matumoto S, et al: Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models. Crit Care Med 2009; 37:626-633
20. He X, Han B, Mura M, et al: Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats. Shock 2007; 28:106-111
21. Wang F, Xia ZF, Chen XL, et al: Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury. Cytokine 2009; 48:246-253
22. Rudiger A, Harjola VP, Müller A, et al: Acute heart failure: Clinical presentation, one-year mortality and prognostic factors. Eur J Heart Fail 2005; 7:662-670
23. Vlaar AP, Binnekade JM, Prins D, et al: Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case-control study. Crit Care Med 2010; 38:771-778
24. Bernard GR, Artigas A, Brigham KL, et al: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149(3 Pt 1):818-824
25. Gajic O, Gropper MA, Hubmayr RD: Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med 2006; 34(Suppl 5):S109-S113
26. Arts DG, De Keizer NF, Scheffer GJ: Defining and improving data quality in medical registries: A literature review, case study, and generic framework. J Am Med Inform Assoc 2002; 9:600-611
27. Arts D, de Keizer N, Scheffer GJ, et al: Quality of data collected for severity of illness scores in the Dutch National Intensive Care Evaluation (NICE) registry. Intensive Care Med 2002; 28:656-659
28. Schisterman EF, Cole SR, Platt RW: Overadjustment bias and unnecessary adjustment in epidemiologic studies. Epidemiology 2009; 20:488-495
29. Shannon P, Markiel A, Ozier O, et al: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res 2003; 13:2498-2504
30. Robins JM: Data, design, and background knowledge in etiologic inference. Epidemiology 2001; 12:313-320
31. Victora CG, Huttly SR, Fuchs SC, et al: The role of conceptual frameworks in epidemiological analysis: A hierarchical approach. Int J Epidemiol 1997; 26:224-227
32. Pearl J: Why there is no statistical test for confounding, why many think there is, and why they are almost right. In: Causality: Models, Reasoning and Inference. Cambridge, England, Cambridge University Press, 2009, p 182f
33. Christensen S, Thomsen RW, Johansen MB, et al: Preadmission statin use and one-year mortality among patients in intensive care- A cohort study. Crit Care 2010; 14:R29
34. Terblanche M, Almog Y, Rosenson RS, et al: Statins and sepsis: Multiple modifications at multiple levels. Lancet Infect Dis 2007; 7:358-368
35. Gajic O, Rana R, Winters JL, et al: Transfusion-related acute lung injury in the critically ill: Prospective nested case-control study. Am. J. Respir. Crit. Care Med 2007; 176:886-891
36. Moore SB: Transfusion-related acute lung injury (TRALI): Clinical presentation, treatment, and prognosis. Crit Care Med 2006; 34(Suppl 5):S114-S117