Kynurenine and hypotension: Historic perspectives

Critical Care Medicine

Volumn 40, Issue 6, 2012, Pages 2006-

  Oxenkrug, Gregory F ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KYNURENINE;

BLOOD PRESSURE; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; VASODILATATION;

FEMALE; HUMANS; HYPOTENSION; KYNURENINE; MALE; SHOCK, SEPTIC; TRYPTOPHAN;

EID: 84861511461     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31824e1e3b     Document Type: Letter

References (14)

1. Eiserich JP, Hayakawa KA, Cross CE: Sepsis and hypotension: Enter kynurenine, move over nitric oxide. Crit Care Med 2011; 39:2767-2769
2. Changsirivathanathamrong D, Wang Y, Rajbhandari D, et al: Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Crit Care Med 2011; 39:2678-2683
3. Changsirivathanathamrong D, Wang Y, Woolfe C, et al: Kynurenine is a novel vasodilator in human septic shock [Abstract 3679]. Circulation 2008; 118:S465
4. Wang Y, Liu H, McKenzie G, et al: Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med 2010; 16:279-285
5. Wang Y, Liu H, McKenzie G, et al: Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation. BMC Pharmacology 2009; 9:S39
6. Hofmann F: Ido brings down the pressure in systemic inflammation. Nat Med 2010; 16:265-267
7. Lapin IP: Depressor effect of kynurenine and its metabolites in rats. Life Sci 1976; 19:1479-1483
8. Lapin IP, Umanskaia LG: Effect of kynurenine and its metabolites on the vascular effects of serotonin, noradrenaline, and acetylcholine. Biull Eksp Biol Med 1980; 89:704-706
9. Lapin IP, Oxenkrug GF: Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet 1969; 1:32-39
10. Lapin IP: Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety. Adv Exp Med Biol 2003; 527:121-125
11. Lapin IP: Kynurenines and seizures. Epilepsia 1981; 22:257-265
12. Lapin IP: Kynurenines as probable participants of depression. Pharmakopsychiatr Neuropsychopharmakol 1973; 6:273-279
13. Wonodi I, Schwarcz R: Cortical kynurenine pathway metabolism: A novel target for cognitive enhancement in Schizophrenia. Schizophr Bull 2010; 36:211-218
14. Oxenkrug GF: Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: The serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci 2010; 47:56-63