메뉴 건너뛰기




Volumn 35, Issue 3, 2012, Pages 134-140

Selegiline: A reappraisal of its role in parkinson disease

Author keywords

MAO B inhibitors; Parkinson disease; selegiline

Indexed keywords

BROMOCRIPTINE; CARBIDOPA PLUS LEVODOPA; LEVODOPA; RASAGILINE; SELEGILINE; TOCOPHEROL;

EID: 84861510378     PISSN: 03625664     EISSN: 1537162X     Source Type: Journal    
DOI: 10.1097/WNF.0b013e318255838b     Document Type: Review
Times cited : (42)

References (55)
  • 1
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson disease: The TEMPO Study
    • Parkinson Study Group.
    • Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol 2002;59(12):1937Y1943.
    • (2002) Arch. Neurol. , vol.59 , Issue.12 , pp. 1937-1943
  • 2
    • 67651165337 scopus 로고    scopus 로고
    • Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease
    • Hauser RA, Lew MF, Hurtig HI, et al. Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease. Mov Disord 2009;24(4):564Y573.
    • (2009) Mov. Disord. , vol.24 , Issue.4 , pp. 564-573
    • Hauser, R.A.1    Lew, M.F.2    Hurtig, H.I.3
  • 3
    • 15844386001 scopus 로고    scopus 로고
    • Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, lasting effect in adjunct therapy with rasagiline given once daily, study): A randomised, double-blind, parallel-group trial
    • Rascol O, Brooks DJ, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Lancet 2005;365(9463):947Y954.
    • (2005) Lancet , vol.365 , Issue.9463 , pp. 947-954
    • Rascol, O.1    Brooks, D.J.2    Melamed, E.3
  • 4
    • 70349456475 scopus 로고    scopus 로고
    • A double-blind, delayed-start trial of rasagiline in Parkinson's disease
    • Olanow CW, Rascol O, Hauser R, et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med 2009;361(13):1268Y1278.
    • (2009) N. Engl. J. Med. , vol.361 , Issue.13 , pp. 1268-1278
    • Olanow, C.W.1    Rascol, O.2    Hauser, R.3
  • 5
    • 77949378919 scopus 로고    scopus 로고
    • Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression
    • Sampaio C, Ferreira JJ. Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression. Nat Rev Neurol 2010;6(3):126Y128.
    • (2010) Nat. Rev. Neurol. , vol.6 , Issue.3 , pp. 126-128
    • Sampaio, C.1    Ferreira, J.J.2
  • 6
    • 0026150396 scopus 로고
    • Selegiline A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease
    • Chrisp P, Mammen GJ, Sorkin EM. Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease. Drugs Aging 1991;1(3):228Y248.
    • (1991) Drugs Aging , vol.1 , Issue.3 , pp. 228-248
    • Chrisp, P.1    Mammen, G.J.2    Sorkin, E.M.3
  • 7
    • 0029099867 scopus 로고
    • Selegiline: A review of its clinical efficacy in Parkinson's disease and its clinical potential in Alzheimer's disease
    • Wiseman LR, McTavish D. Selegiline: a review of its clinical efficacy in Parkinson's disease and its clinical potential in Alzheimer's disease. CNS Drugs 1995;4(3):230Y246.
    • (1995) CNS Drugs , vol.4 , Issue.3 , pp. 230-246
    • Wiseman, L.R.1    McTavish, D.2
  • 8
    • 77952118055 scopus 로고    scopus 로고
    • [online]. Available at: Accessed February 15
    • Eldepryl. Summary of product characteristics [online]. Available at: http://www.medicines.org.uk/emc/medicine/13200. Accessed February 15, 2011.
    • (2011) Eldepryl Summary of Product Characteristics
  • 9
    • 0031901862 scopus 로고    scopus 로고
    • Safety of selegiline (deprenyl) in the treatment of Parkinson's disease
    • Heinonen EH, Myllyla V. Safety of selegiline (deprenyl) in the treatment of Parkinson's disease. Drug Saf 1998;19(1):11Y22.
    • (1998) Drug Saf. , vol.19 , Issue.1 , pp. 11-22
    • Heinonen, E.H.1    Myllyla, V.2
  • 10
    • 0028593637 scopus 로고
    • Amphetamine-like effect of L-deprenyl (selegiline) in drug discrimination studies
    • 6 Pt 2
    • Yasar S, Bergman J. Amphetamine-like effect of L-deprenyl (selegiline) in drug discrimination studies. Clin Pharmacol Ther 1994; 56(6 Pt 2):768Y773.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 768-773
    • Yasar, S.1    Bergman, J.2
  • 11
    • 28344449888 scopus 로고    scopus 로고
    • A comparison of drug-seeking behavior maintained by D-amphetamine L-deprenyl (selegiline) and D-deprenyl under a second-order schedule in squirrel monkeys
    • Yasar S, Gaal J, Panlilio LV, et al. A comparison of drug-seeking behavior maintained by D-amphetamine, L-deprenyl (selegiline), and D-deprenyl under a second-order schedule in squirrel monkeys. Psychopharmacology (Berl) 2006;183(4):413Y421.
    • (2006) Psychopharmacology (Berl. , vol.183 , Issue.4 , pp. 413-421
    • Yasar, S.1    Gaal, J.2    Panlilio, L.V.3
  • 12
    • 0030008656 scopus 로고    scopus 로고
    • The effect of dosing regimen and food on the bioavailability of the extensively metabolized, highly variable drug Eldepryl(\) (selegiline hydrochloride
    • Barrett JS, Rohatagi S, DeWitt KE, et al. The effect of dosing regimen and food on the bioavailability of the extensively metabolized, highly variable drug Eldepryl(\) (selegiline hydrochloride). Am J Ther 1996;3(4):298Y313.
    • (1996) Am. J. Ther. , vol.3 , Issue.4 , pp. 298-313
    • Barrett, J.S.1    Rohatagi, S.2    DeWitt, K.E.3
  • 13
    • 0031958859 scopus 로고    scopus 로고
    • Drug-delivery products and the Zydis fast-dissolving dosage forms
    • Seager H. Drug-delivery products and the Zydis fast-dissolving dosage forms. J Pharm Pharmacol 1998;50(4):375Y382.
    • (1998) J. Pharm. Pharmacol. , vol.50 , Issue.4 , pp. 375-382
    • Seager, H.1
  • 14
    • 0345189359 scopus 로고    scopus 로고
    • A new formulation of selegiline: Improved bioavailability and selectivity for MAO-B inhibition
    • Clarke A, Brewer F, Johnson ES, et al. A new formulation of selegiline: improved bioavailability and selectivity for MAO-B inhibition. J Neural Transm 2003;110(11):1241Y1255.
    • (2003) J. Neural. Transm. , vol.110 , Issue.11 , pp. 1241-1255
    • Clarke, A.1    Brewer, F.2    Johnson, E.S.3
  • 15
    • 0347415712 scopus 로고    scopus 로고
    • Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation
    • Youdim MB, Weinstock M. Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation. Neurotoxicology 2004;25 (1Y2):243Y250.
    • (2004) Neurotoxicology , vol.25 , Issue.1-2 , pp. 243-250
    • Youdim, M.B.1    Weinstock, M.2
  • 16
    • 66949117423 scopus 로고    scopus 로고
    • The scientific and clinical basis for the treatment of Parkinson disease (2009
    • Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson disease (2009). Neurology 2009; 72(21 suppl 4):S1YS136.
    • (2009) Neurology , vol.72 , Issue.21 SUPPL. 4
    • Olanow, C.W.1    Stern, M.B.2    Sethi, K.3
  • 17
    • 0021712735 scopus 로고
    • Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridine (MPTP) in monkeys
    • Cohen G, Pasik P, Cohen B, et al. Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys. Eur J Pharmacol 1984;106(1):209Y210.
    • (1984) Eur. J. Pharmacol. , vol.106 , Issue.1 , pp. 209-210
    • Cohen, G.1    Pasik, P.2    Cohen, B.3
  • 18
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine by monoamine oxidase inhibitors
    • Heikkila RE, Manzino L, Cabbat FS, et al. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5, 6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984;311(5985):467Y469.
    • (1984) Nature , vol.311 , Issue.5985 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3
  • 19
    • 0026353406 scopus 로고
    • Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism
    • Tatton WG, Greenwood CE. Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. J Neurosci Res 1991;30(4):666Y672.
    • (1991) J. Neurosci. Res. , vol.30 , Issue.4 , pp. 666-672
    • Tatton, W.G.1    Greenwood, C.E.2
  • 20
    • 33750858897 scopus 로고    scopus 로고
    • Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases
    • Ebadi M, Brown-Borg H, Ren J, et al. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Curr Drug Targets 2006;7(11):1513Y1529.
    • (2006) Curr. Drug Targets. , vol.7 , Issue.11 , pp. 1513-1529
    • Ebadi, M.1    Brown-Borg, H.2    Ren, J.3
  • 21
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Study Group.
    • Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328(3):176Y183.
    • (1993) N. Engl. J. Med. , vol.328 , Issue.3 , pp. 176-183
  • 22
    • 0024343466 scopus 로고
    • The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
    • Tetrud JW, Langston JW. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science 1989;245(4917): 519Y522.
    • (1989) Science , vol.245 , Issue.4917 , pp. 519-522
    • Tetrud, J.W.1    Langston, J.W.2
  • 23
    • 84996067716 scopus 로고
    • Selegiline as primary treatment in early phase parkinson's diseaseyan interim report
    • Myllyla VV, Sotaniemi KA, Tuominen J, et al. Selegiline as primary treatment in early phase Parkinson's diseaseYan interim report. Acta Neurol Scand Suppl 1989;126:177Y182.
    • (1989) Acta. Neurol. Scand. Suppl. , vol.126 , pp. 177-182
    • Myllyla, V.V.1    Sotaniemi, K.A.2    Tuominen, J.3
  • 24
    • 0028858370 scopus 로고
    • The effect of deprenyl and levodopa on the progression of Parkinson's disease
    • Olanow CW, Hauser RA, Gauger L, et al. The effect of deprenyl and levodopa on the progression of Parkinson's disease. Ann Neurol 1995;38(5):771Y777.
    • (1995) Ann. Neurol. , vol.38 , Issue.5 , pp. 771-777
    • Olanow, C.W.1    Hauser, R.A.2    Gauger, L.3
  • 25
    • 0024456653 scopus 로고
    • Effect of deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Study Group.
    • Parkinson Study Group. Effect of deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1989;321(20):1364Y1371.
    • (1989) N. Engl. J. Med. , vol.321 , Issue.20 , pp. 1364-1371
  • 26
    • 0035954349 scopus 로고    scopus 로고
    • Freezing of gait in PD: Prospective assessment in the DATATOP cohort
    • Giladi N, McDermott MP, Fahn S, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology 2001;56(12):1712Y1721.
    • (2001) Neurology , vol.56 , Issue.12 , pp. 1712-1721
    • Giladi, N.1    McDermott, M.P.2    Fahn, S.3
  • 27
    • 0033385038 scopus 로고    scopus 로고
    • Does selegiline modify the progression of early Parkinson's disease Results from a five-year study
    • The Norwegian-Danish Study Group
    • Larsen JP, Boas J, Erdal JE. Does selegiline modify the progression of early Parkinson's disease? Results from a five-year study. The Norwegian-Danish Study Group. Eur J Neurol 1999;6(5):539Y547.
    • (1999) Eur. J. Neurol. , vol.6 , Issue.5 , pp. 539-547
    • Larsen, J.P.1    Boas, J.2    Erdal, J.E.3
  • 28
    • 33646686620 scopus 로고    scopus 로고
    • Selegiline slows the progression of the symptoms of Parkinson disease
    • Palhagen S, Heinonen E, Hagglund J, et al. Selegiline slows the progression of the symptoms of Parkinson disease. Neurology 2006;66(8): 1200Y1206.
    • (2006) Neurology , vol.66 , Issue.8 , pp. 1200-1206
    • Palhagen, S.1    Heinonen, E.2    Hagglund, J.3
  • 29
    • 4544279090 scopus 로고    scopus 로고
    • Monoamine oxidase type B inhibitors in early Parkinson's disease: Meta-analysis of 17 randomised trials involving 3525 patients
    • Ives NJ, Stowe RL, Marro J, et al. Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients. BMJ 2004;329(7466):593.
    • (2004) BMJ , vol.329 , Issue.7466 , pp. 593
    • Ives, N.J.1    Stowe, R.L.2    Marro, J.3
  • 30
    • 0037039267 scopus 로고    scopus 로고
    • Practice parameter: Initiation of treatment for parkinson's disease: An evidence-based review: Report of the quality standards subcommittee of the american academy of neurology
    • Miyasaki JM, Martin W, Suchowersky O, et al. Practice parameter: initiation of treatment for Parkinson's disease: an evidence-based review: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2002;58(1):11Y17.
    • (2002) Neurology , vol.58 , Issue.1 , pp. 11-17
    • Miyasaki, J.M.1    Martin, W.2    Suchowersky, O.3
  • 32
    • 0033038628 scopus 로고    scopus 로고
    • SELEDO: A 5-year long-term trial on the effect of selegiline in early Parkinsonian patients treated with levodopa
    • Przuntek H, Conrad B, Dichgans J, et al. SELEDO: a 5-year long-term trial on the effect of selegiline in early Parkinsonian patients treated with levodopa. Eur J Neurol 1999;6(2):141Y150.
    • (1999) Eur. J. Neurol. , vol.6 , Issue.2 , pp. 141-150
    • Przuntek, H.1    Conrad, B.2    Dichgans, J.3
  • 33
    • 76749121372 scopus 로고    scopus 로고
    • Early addition of selegiline to L-dopa treatment is beneficial for patients with Parkinson disease
    • Mizuno Y, Kondo T, Kuno S, et al. Early addition of selegiline to L-dopa treatment is beneficial for patients with Parkinson disease. Clin Neuropharmacol 2010;33(1):1Y4.
    • (2010) Clin. Neuropharmacol. , vol.33 , Issue.1 , pp. 1-4
    • Mizuno, Y.1    Kondo, T.2    Kuno, S.3
  • 34
    • 80052641121 scopus 로고    scopus 로고
    • The natural history of treated Parkinson's disease in an incident, community based cohort
    • Vans JR, Mason SL, Williams-Gray CH, et al. The natural history of treated Parkinson's disease in an incident, community based cohort. J Neurol Neurosurg Psychiatry 2011;82(10):1112Y1118.
    • (2011) J. Neurol. Neurosurg. Psychiatry , vol.82 , Issue.10 , pp. 1112-1118
    • Vans, J.R.1    Mason, S.L.2    Williams-Gray, C.H.3
  • 35
    • 79951554114 scopus 로고    scopus 로고
    • Selegiline use is associated with a slower progression in early Parkinson's disease as evaluated by Hoehn and Yahr Stage transition times
    • Zhao YJ, Wee HL, Au WL, et al. Selegiline use is associated with a slower progression in early Parkinson's disease as evaluated by Hoehn and Yahr Stage transition times. Parkinsonism Relat Disord 2011;17(3):194Y197.
    • (2011) Parkinsonism. Relat. Disord. , vol.17 , Issue.3 , pp. 194-197
    • Zhao, Y.J.1    Wee, H.L.2    Au, W.L.3
  • 36
    • 33750067356 scopus 로고    scopus 로고
    • Review of the therapeutic management of parkinson's disease report of a joint task force of the european federation of neurological societies and the movement disorder society european section part i: Early (uncomplicated) parkinson's disease
    • Horstink M, Tolosa E, Bonuccelli U, et al. Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies and the Movement Disorder SocietyYEuropean Section. Part I: early (uncomplicated) Parkinson's disease. Eur J Neurol 2006;13(11):1170Y1185.
    • (2006) Eur. J. Neurol. , vol.13 , Issue.11 , pp. 1170-1185
    • Horstink, M.1    Tolosa, E.2    Bonuccelli, U.3
  • 37
    • 33750077251 scopus 로고    scopus 로고
    • Review of the therapeutic management of parkinson's disease report of a joint task force of the european federation of neurological societies (efns) and the movement disorder society-european section (MDS-ES) Part II: Late (complicated) Parkinson's disease
    • Horstink M, Tolosa E, Bonuccelli U, et al. Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson's disease. Eur J Neurol 2006;13(11):1186Y1202.
    • (2006) Eur. J. Neurol. , vol.13 , Issue.11 , pp. 1186-1202
    • Horstink, M.1    Tolosa, E.2    Bonuccelli, U.3
  • 38
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • rkinson Study Group.
    • Parkinson Study Group. A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol 2004;61(4):561Y566.
    • (2004) Arch. Neurol. , vol.61 , Issue.4 , pp. 561-566
  • 39
    • 0036231440 scopus 로고    scopus 로고
    • Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial
    • Shoulson I, Oakes D, Fahn S, et al. Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial. Ann Neurol 2002;51(5):604Y612.
    • (2002) Ann.Neurol. , vol.51 , Issue.5 , pp. 604-612
    • Shoulson, I.1    Oakes, D.2    Fahn, S.3
  • 40
    • 52649164003 scopus 로고    scopus 로고
    • Medical treatment of freezing of gait
    • Giladi N. Medical treatment of freezing of gait. Mov Disord 2008; 23(suppl 2):S482YS488.
    • (2008) Mov. Disord. , vol.23 , Issue.SUPPL. 2
    • Giladi, N.1
  • 41
    • 0029731809 scopus 로고    scopus 로고
    • Role of selegiline in combination therapy of Parkinson's disease
    • Myllyla VV, Sotaniemi K, Maki-Ikola O, et al. Role of selegiline in combination therapy of Parkinson's disease. Neurology 1996; 47(6 suppl 3):S200YS209.
    • (1996) Neurology , vol.47 , Issue.6 SUPPL. 3
    • Myllyla, V.V.1    Sotaniemi, K.2    Maki-Ikola, O.3
  • 42
    • 3242784708 scopus 로고
    • Deprenyl in the treatment of symptom fluctuations in adVanced Parkinson's disease
    • Golbe LI, Lieberman AN, Muenter MD, et al. Deprenyl in the treatment of symptom fluctuations in adVanced Parkinson's disease. Clin Neuropharmacol 1988;11(1):45Y55.
    • (1988) Clin. Neuropharmacol. , vol.11 , Issue.1 , pp. 45-55
    • Golbe, L.I.1    Lieberman, A.N.2    Muenter, M.D.3
  • 43
    • 0023507276 scopus 로고
    • Deprenyl versus placebo in Parkinson disease: A double-blind study
    • Lieberman AN, Gopinathan G, Neophytides A, et al. Deprenyl versus placebo in Parkinson disease: a double-blind study. N Y State J Med 1987;87(12):646Y649.
    • (1987) N. Y. State. J. Med. , vol.87 , Issue.12 , pp. 646-649
    • Lieberman, A.N.1    Gopinathan, G.2    Neophytides, A.3
  • 44
    • 84996059578 scopus 로고
    • Selegiline and levodopa in early or moderately adVanced Parkinson's disease: A double-blind controlled short- and long-term study
    • Sivertsen B, Dupont E, Mikkelsen B, et al. Selegiline and levodopa in early or moderately adVanced Parkinson's disease: a double-blind controlled short- and long-term study. Acta Neurol Scand Suppl 1989;126:147Y152.
    • (1989) Acta. Neurol. Scand. Suppl. , vol.126 , pp. 147-152
    • Sivertsen, B.1    Dupont, E.2    Mikkelsen, B.3
  • 45
    • 34848857679 scopus 로고    scopus 로고
    • Selegiline orally disintegrating tablets in patients with Parkinson disease and ''wearing off '' symptoms
    • Ondo WG, Sethi KD, Kricorian G. Selegiline orally disintegrating tablets in patients with Parkinson disease and ''wearing off '' symptoms. Clin Neuropharmacol 2007;30(5):295Y300.
    • (2007) Clin. Neuropharmacol. , vol.30 , Issue.5 , pp. 295-300
    • Ondo, W.G.1    Sethi, K.D.2    Kricorian, G.3
  • 46
    • 2342426425 scopus 로고    scopus 로고
    • Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study
    • Waters CH, Sethi KD, Hauser RA, et al. Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: a 3-month, randomized, placebo-controlled study. Mov Disord 2004;19(4): 426Y432.
    • (2004) Mov. Disord. , vol.19 , Issue.4 , pp. 426-432
    • Waters, C.H.1    Sethi, K.D.2    Hauser, R.A.3
  • 47
    • 79551499995 scopus 로고    scopus 로고
    • Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease
    • Ondo WG, Hunter C, Isaacson SH, et al. Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease. Parkinsonism Relat Disord 2011;17(2):117Y118.
    • (2011) Parkinsonism. Relat. Disord. , vol.17 , Issue.2 , pp. 117-118
    • Ondo, W.G.1    Hunter, C.2    Isaacson, S.H.3
  • 48
    • 13444302612 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: The PRESTO study
    • Parkinson Study Group.
    • Parkinson Study Group. A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study. Arch Neurol 2005;62(2):241Y248.
    • (2005) Arch. Neurol. , vol.62 , Issue.2 , pp. 241-248
  • 49
    • 9044227267 scopus 로고
    • Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild parkinson's disease parkinson's disease research group of the united kingdom
    • Lees AJ. Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease. Parkinson's Disease Research Group of the United Kingdom. BMJ 1995;311(7020):1602Y1607.
    • (1995) BMJ , vol.311 , Issue.7020 , pp. 1602-1607
    • Lees, A.J.1
  • 50
    • 0032542955 scopus 로고    scopus 로고
    • Investigation by parkinson's disease research group of united kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: Further results of randomised trial and confidential inquiry
    • Ben-Shlomo Y, Churchyard A, Head J, et al. Investigation by Parkinson's Disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: further results of randomised trial and confidential inquiry. BMJ 1998;316(7139):1191Y1196.
    • (1998) BMJ , vol.316 , Issue.7139 , pp. 1191-1196
    • Ben-Shlomo, Y.1    Churchyard, A.2    Head, J.3
  • 51
    • 0031893241 scopus 로고    scopus 로고
    • Mortality in DATATOP: A multicenter trial in early Parkinson's disease
    • Parkinson Study Group.
    • Parkinson Study Group. Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Ann Neurol 1998;43(3):318Y325.
    • (1998) Ann. Neurol. , vol.43 , Issue.3 , pp. 318-325
  • 52
    • 0031750983 scopus 로고    scopus 로고
    • Effect of selegiline on mortality in patients with Parkinson's disease: A meta-analysis
    • Olanow CW, Myllyla VV, Sotaniemi KA, et al. Effect of selegiline on mortality in patients with Parkinson's disease: a meta-analysis. Neurology 1998;51(3):825Y830.
    • (1998) Neurology , vol.51 , Issue.3 , pp. 825-830
    • Olanow, C.W.1    Myllyla, V.V.2    Sotaniemi, K.A.3
  • 54
    • 67650462721 scopus 로고    scopus 로고
    • Selegiline transdermal system: A novel treatment option for major depressive disorder
    • Nandagopal JJ, DelBello MP. Selegiline transdermal system: a novel treatment option for major depressive disorder. Expert Opin Pharmacother 2009;10(10):1665Y1773.
    • (2009) Expert Opin. Pharmacother. , vol.10 , Issue.10 , pp. 1665-1773
    • Nandagopal, J.J.1    DelBello, M.P.2
  • 55
    • 84863229239 scopus 로고    scopus 로고
    • Selegiline transdermal system (STS) as an aid for smoking cessation
    • Kahn R, Gorgon L, Jones K, et al. Selegiline transdermal system (STS) as an aid for smoking cessation. Nicotine Tob Res 2012;14(3):377Y382.
    • (2012) Nicotine Tob. Res. , vol.14 , Issue.3 , pp. 377-382
    • Kahn, R.1    Gorgon, L.2    Jones, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.