Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

International Journal of Molecular Medicine

Volumn 30, Issue 1, 2012, Pages 93-99

  Liu, Ling ^a,b   Lin, Zhi Xiu ^a   Leung, Po Sing ^b   Chen, Li Hua ^b   Zhao, Ming ^a   Liang, Juan ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Prince of Wales Hospital   (Hong Kong)

Author keywords

Apoptosis; Bruceine D; Capan 2 cells; Mitochondrial pathway; Pancreatic cancer

Indexed keywords

BRUCEINE D; CAMPTOTHECIN; CASPASE 3; CASPASE 9; CELL DNA; GEMCITABINE; GENOMIC DNA; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER STEM CELL; CELL ASSAY; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; INTRACELLULAR SIGNALING; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRUCEA; CAMPTOTHECIN; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DEOXYCYTIDINE; DNA DAMAGE; DRUGS, CHINESE HERBAL; HEPATOCYTES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUASSINS; STEM CELLS;

EID: 84861478196     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.980     Document Type: Article

References (16)

1. Wanebo HJ and Vezeridis MP: Pancreatic carcinoma in perspective. A continuing challenge. Cancer 78: 580-591, 1996. (Pubitemid 26251517)
2. Blackstock AW, Cox AD and Tepper JE: Treatment of pancreatic cancer: current limitations, future possibilities. Oncology 10: 301-307, 1996. (Pubitemid 26135274)
3. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistic. CA Cancer J Clin 58: 71-96, 2008.
4. Oettle. H, Post S, Neuhaus P, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, Schramm H, Fahlke J, Zuelke C, Burkart C, Gutberlet K, Kettner E, Schmalenberg H, Koehler KW, Bechstein WO, Niedergethmann M, Wolf IS, Roll L, Doerken B and Riess H: Adjuvant chemotherapy with gemcitabine vs observation in patient undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 297: 267-277, 2007. (Pubitemid 46143304)
5. Barton-Burke M: Gemcitabine: a pharmacologic and clinical review. Cancer Nurs 22: 176-183, 1999.
6. Hui YF and Reitz J: Gemcitabine: a cytidine analogue active against solid tumors. Am J Health Syst Pharm 54: 162-170, 1997. (Pubitemid 27058210)
7. Chang C, Zhu YQ, Mei JJ, Liu SQ and Luo J: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells. J Exp Clin Cancer Res 29: 145, 2010.
8. Lau ST, Lin ZX, Zhao M and Leung PS: Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines. Phytotherapy Res 22: 477-486, 2008. (Pubitemid 351613412)
9. Lau ST, Lin ZX, Liao YH, Zhao M, Cheng CHK and Leung PS: Brucein D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein. Cancer Lett 281: 42-52, 2009.
10. Lin ZX, Hoult JRS and Raman A: Sulforhodamine B assay for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of crude drugs used in the treatment of vitiligo. J Ethnopharmacol 66: 141-150, 1999. (Pubitemid 29307912)
11. Suen PM, Zou C, Zhang YA, Lau TK, Chan J, Yao KM and Leung PS: PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. Int J Biochem Cell Biol 40: 789-803, 2008. (Pubitemid 351288600)
12. Leung KK, Suen PM, Lau TK, Ko WH, Yao KM and Leung PS: PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. Stem Cells Development 18: 979-990, 2009.
13. He LJ, Lou HQ and Xiang L: Efficacy of Brucea javanica oil emulsion combined radiotherapy on treating advanced esophageal carcinoma. Chin J Exp Trad Med Formul 16: 212-215, 2010.
14. Zhao BY and Fang M: Brucea javanica oil emulsion combined cisplatin and etoposide in the treatment of small cell lung cancer in advanced stage. J Clin Pulmon Med 15: 1233-1234, 2010.
15. Lu HJ, Xu H and Ning SQ: Treatment of advanced gastric cancer with DX chemotherapy and Bruceolic oil emulsion. Pract J Clin Med 7: 76-77, 2010.
16. Wang Q, Frolova AI, Purcell S, Adastra K, Schoeller E, Chi MM, Schedl T and Moley KH: Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. PLoS One 5: e15901, 2010.