Evidence for reduced angiogenesis in bone marrow in SSc: Immunohistochemistry and multiparametric computerized imaging analysis

Rheumatology (United Kingdom)

Volumn 51, Issue 6, 2012, Pages 1042-1048

  Carrai, Valentina ^a   Miniati, Irene ^a   Guiducci, Serena ^a   Capaccioli, Gloria ^a   Alterini, Renato ^a   Saccardi, Riccardo ^a   Conforti, Maria L ^a   Rigacci, Luigi ^a   Rotunno, Giada ^a   Bosi, Alberto ^a   Cerinic, Marco Matucci ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Angiogenesis; Bone marrow; Fibrosis; Systemic sclerosis; VEGF

Indexed keywords

CD34 ANTIGEN; GELATINASE B; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BONE MARROW; BONE MARROW BIOPSY; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FIBROSIS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; SILVER IMPREGNATION; SYSTEMIC SCLEROSIS; VASCULARIZATION;

ADULT; ANTIGENS, CD34; BIOPSY; BONE MARROW; ENDOTHELIAL CELLS; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MALE; MATRIX METALLOPROTEINASE 9; MESENCHYMAL STROMAL CELLS; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; SCLERODERMA, SYSTEMIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84861470552     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ker447     Document Type: Article

References (24)

1. LeRoy EC. Systemic sclerosis. A vascular perspective. Rheum Dis Clin North Am 1996;22:675-94.
2. Blann AD, Illingworth K, Jayson MI. Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud's phenomenon. J Rheumatol 1993;20: 1325-30.
3. Chung L, Fiorentino D. Digital ulcers in patients with systemic sclerosis. Autoimmun Rev 2006;5:125-8.
4. Distler O, Distler JH, Scheid A et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004;95: 109-16.
5. Choi JJ, Min DJ, Lacho M et al. Elevated vascular endothelial growth factor in systemic sclerosis. J Rheumatol 2003;30:1529-33.
6. Allanore Y, Batteux F, Avouac J et al. Levels of circulating endothelial progenitor cells in systemic sclerosis. Clin Exp Rheumatol 2007;25:60-6.
7. Cipriani P, Guiducci S, Miniati I et al. Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum 2007;56: 1994-2004.
8. Lemaire R, Korn JH, Shipley JM et al. Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma. Arthritis Rheum 2005;52:1812-23.
9. Tyndall A, Daikeler T. Autologous hematopoietic stem cell transplantation for autoimmune diseases. Acta Haematol 2005;114:239-47.
10. Farge D, Passweg J, van Laar JM et al. Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry. Ann Rheum Dis 2004;63:974-81.
11. Boveri E, Passamonti F, Rumi E et al. Bone marrow micro vessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations. Br J Haematol 2008;140:162-8.
12. Aguayo A, Kantarjian H, Manshouri T et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood 2000;96:2240-5.
13. Kuzu I, Beksac M, Arat M et al. Bone marrow microvessel density (MVD) in adult acute myeloid leukaemia (AML): therapy induced changes and effects on survival. Leuk Lymphoma 2004;45:1185-90.
14. Bauermeister DE. Quantification of bone marrow reticulina normal range. Am J Clin Pathol 1971;56:24-31.
15. Kvasnicka HM, Thiele J. Bone marrow angiogenesis: methods of quantification and changes evolving in chronic myeloproliferative disorders. Histol Histopathol 2004;19: 1245-60.
16. Sunderkotter C, Goebeler M, Schulze-Osthoff K et al. Macrophage-derived angiogenesis factors. Pharamacol Ther 1991;51:195-216.
17. Cutolo M, Pizzorni C, Sulli A. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000;27:155-60.
18. Kuwana M, Okazaki Y, Yasuoka H et al. Defective vasculogenesis in systemic sclerosis. Lancet 2004;364: 14.
19. Del Papa N, Quirici N, Soligo D et al. Bone marrow endothelial progenitors are defective in systemic sclerosis. Arthritis Rheum 2006;54:2605-15.
20. Dor Y, Djonov V, Abramovitch R et al. Conditional switching of VEGF provides new insights into adult neovascularisation and pro-angiogenic therapy. EMBO J 2002;21:1939-47.
21. Faller DV. Endothelial cell repsonses to hypoxic stress. Clin Exp Pharmacol Physiol 1999;146:1541-5.
22. Kikuchi K, Kubo M, Kadono T et al. Serum concentration of vascular endothelial growth factor in collagen diseases. Br J Dermatol 1998;139:1049-51.
23. Kikuchi K, Kubo M, Hoashi T et al. Decreased MMP-9 activity in the serum of patients with diffuse cutaneous systemic sclerosis. Clin Exp Dermatol 2002;27:301-5.
24. Kim WU, Min SY, Cho ML et al. Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. Arthritis Res Ther 2005;7:71-9.