Longitudinal trajectories of awareness in early-stage dementia

Alzheimer Disease and Associated Disorders

Volumn 26, Issue 2, 2012, Pages 140-147

  Clare, Linda ^a   Nelis, Sharon M ^a   Martyr, Anthony ^a   Whitaker, Christopher J ^a   Marková, Ivana S ^b   Roth, Ilona ^c   Woods, Robert T ^a   Morris, Robin G ^d  

^a BANGOR UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF HULL   (United Kingdom)

^c OPEN UNIVERSITY   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer disease; anosognosia; insight; meta cognition; vascular dementia

Indexed keywords

AGED; ARTICLE; AWARENESS; DAILY LIFE ACTIVITY; DEMENTIA; DISEASE COURSE; FEMALE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY; MOOD; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; STRESS;

AGED; AGED, 80 AND OVER; AWARENESS; CAREGIVERS; DEMENTIA; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; QUALITY OF LIFE; QUESTIONNAIRES; SELF CONCEPT; STRESS, PSYCHOLOGICAL;

EID: 84861459512     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e31822c55c4     Document Type: Article

References (46)

1. Clare L., Rowlands J., Bruce E., et al. "I don't do like I used to do": a grounded theory approach to conceptualising awareness in people with moderate to severe dementia living in longterm care. Soc Sci Med. 2008;66:2366-2377. (Pubitemid 351608732)
2. Clare L. The construction of awareness in early-stage Alzheimer's disease: a review of concepts and models. Br J Clin Psychol. 2004;43:155-175. (Pubitemid 38923509)
3. Aalten P., van Valen E., Clare L., et al. Awareness in dementia: a review of clinical correlates. AgingMent Health. 2005;9:414-422. (Pubitemid 41097714)
4. Marková IS Insight in Psychiatry. Cambridge., UK: Cambridge University Press 2005.
5. Neundorfer MJ. Awareness of variability in awareness. Alzheimer Dis Assoc Disord. 1997;11:121-122.
6. Weinstein EA., Friedland RP., Wagner EE. Denial/unawareness of impairment and symbolic behavior in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol. 1994;7:176-184. (Pubitemid 24268941)
7. McDaniel KD., Edland SD., Heyman A., et al. Relationship between level of insight and severity of dementia in Alzheimer disease. Alzheimer Dis Assoc Disord. 1995;9:101-104.
8. Vasterling JJ., Seltzer B., Foss JW., et al. Unawareness of deficit in Alzheimer's disease: domain-specific differences and disease correlates. Neuropsychiatry Neuropsychol Behav Neurol. 1995; 8:26-32.
9. Kaszniak AW., Christenson GD. One-year longitudinal changes in the metamemory impairment of Alzheimer's disease. J Int Neuropsychol Soc. 1995;1:145.
10. Derouesne C., Thibault S., Lagha-Pierucci S., et al. Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type. Int J Geriatr Psychiatry. 1999;14:1019-1030. (Pubitemid 30066036)
11. Clare L., Wilson BA. Longitudinal assessment of awareness in early-stage Alzheimer's disease using comparable questionnairebased and performance-based measures: a prospective one-year follow up study. Aging Ment Health. 2006;10:156-165. (Pubitemid 43355126)
12. Sevush S. Relationship between denial of memory deficit and dementia severity in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol. 1999;12:88-94. (Pubitemid 30130772)
13. Akai T., Hanyu H., Sakurai H., et al. Longitudinal patterns of unawareness of memory deficits in mild Alzheimer's disease. Geriatr Gerontol Int. 2009;9:16-20.
14. Vasterling JJ., Seltzer B., Carpenter BD., et al. Unawareness of social interaction and emotional control deficits in Alzheimer's disease. Aging Neuropsychol Cognit. 1997;4:280-289. (Pubitemid 28191861)
15. Kiyak HA., Teri L., Borson S. Physical and functional health assessment in normal aging and in Alzheimer's disease: selfreports versus family reports. Gerontologist. 1994;34:324-330. (Pubitemid 24182792)
16. Marková IS., Clare L., Wang M., et al. Awareness in dementia: conceptual issues. Aging Ment Health. 2005;9:386-393. (Pubitemid 41097712)
17. Clare L., Whitaker CJ., Nelis SM. Appraisal of memory functioning and memory performance in healthy ageing and early-stage Alzheimer's disease. Aging Neuropsychol Cognit. 2010;17:462-491.
18. World Health Organisation The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva., Switzerland: World Health Organisation., Division of Mental Health 1992.
19. Folstein MF., Folstein SE., McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
20. Clare L., Wilson BA., Carter G., et al. Assessing awareness in early-stage Alzheimer's disease: development and piloting of the Memory Awareness Rating Scale. Neuropsychol Rehabil. 2002;12:341-362. (Pubitemid 35006180)
21. Pfeffer RI., Kurosaki TT., Harrah C.H., et al. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323-329. (Pubitemid 12117513)
22. Karagiozis H., Gray S., Sacco J., et al. The Direct Assessment of Functional Abilities (DAFA): a comparison to an indirect measure of instrumental activities of daily living. Gerontologist. 1998;38:113-121. (Pubitemid 28128347)
23. Teng E., Becker BW., Woo E., et al. Utility of the Functional Activities Questionnaire for distinguishing mild cognitive impairment from very mild Alzheimer disease. Alzheimer Dis Assoc Disord. 2010;24:348-353.
24. Bramham J., Morris RG., Hornak J., et al. Social and emotional functioning following bilateral and unilateral neurosurgical prefrontal cortex lesions. J Neuropsychol. 2009;3:125-143.
25. Wall S., Williams W., Morris RG., et al. The development of a new measure of social-emotional functioning for young adolescents. J Child Psychol Psychiatr. (In press).
26. Nelis SM., Clare L., Martyr A., et al. Awareness of social and emotional functioning in people with early stage dementia and implications for carers. Aging Ment Health. (In press).
27. Wechsler D. Wechsler Memory Scale. 3rd ed. San Antonio., TX The Psychological Corporation; 1997.
28. Delis DC., Kaplan E., Kramer JH Delis-Kaplan Executive Function System (D-KEFS). London., UK: Pearson 2001.
29. Warrington EK. The Graded Naming Test: a restandardisation. Neuropsychol Rehabil. 1997;7:143-146.
30. Snaith RP., Zigmond AS The Hospital Anxiety and Depression Scale. Windsor., UK: NFER-Nelson 1994.
31. Logsdon RG., Gibbons LE., McCurry SM., et al. Quality of life in Alzheimer's disease: patient and caregiver reports. J Ment Health Aging. 1999;5:21-32. (Pubitemid 29235115)
32. Kaufer D.C.J., Ketchel P., Smith V., et al. Validation of the NPIQ., a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000;12:233-239. (Pubitemid 30303778)
33. Goldberg D General Health Questionnaire (GHQ-12). Windsor., UK: NFER-Nelson 1992.
34. Greene JG., Smith R., Gardiner M., et al. Measuring behavioural disturbance of elderly demented patients in the community and its effect on relatives. Age Ageing. 1982;11: 121-126. (Pubitemid 12102597)
35. West BT. Analyzing longitudinal data with the linear mixed models procedure in SPSS. Eval Health Prof. 2009;32:207-228.
36. Laird NM., Ware JH. Random-effects models for longitudinal data. Biometrics. 1982;38:963-974.
37. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr. 1974;19:716-723.
38. Clare L., Nelis SM., Martyr A., et al. The influence of psychological., social and contextual factors on the expression and measurement of awareness in early-stage dementia: testing a biopsychosocial model. Int J Geriatr Psychiatry. (In press).
39. Starkstein SE., Chemerinski E., Sabe L., et al. Prospective longitudinal study of depression and anosognosia in Alzheimer's disease. Br J Psychiatry. 1997;171:47-52.
40. Zanetti O., Vallotti B., Frisoni GB., et al. Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status. J Gerontol B Psychol Sci Soc Sci. 1999;54:P100-P106. (Pubitemid 29144645)
41. DeBettignies BH., Mahurin RK., Pirozzolo FJ. Insight for impairment in independent living skills in Alzheimer's disease and multi-infarct dementia. J Clin Exp Neuropsychol. 1990; 12:355-363. (Pubitemid 20203703)
42. Jorm AF., Christensen H., Henderson AS., et al. Complaints of cognitive decline in the elderly: a comparison of reports by subjects and informants in a community survey. Psychol Med. 1994;24:365-374. (Pubitemid 24158850)
43. Green J., Goldstein FC., Sirockman BE., et al. Variable awareness of deficits in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol. 1993;6:159-165. (Pubitemid 23220666)
44. Mangone CA., Hier DB., Gorelick PB., et al. Impaired insight in Alzheimer's disease. J Geriatr Psychiatry Neurol. 1991;4: 189-193.
45. Clare L., Markova I., Verhey F., et al. Awareness in dementia: a review of assessment methods and measures. Aging Ment Health. 2005;9:394-413. (Pubitemid 41097713)
46. Trosset MW., Kaszniak AW. Measures of deficit unawareness for predicted performance experiments. J Int Neuropsychol Soc. 1996;2:315-322. (Pubitemid 126449026)