Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy

Amyloid

Volumn 19, Issue SUPPL. 1, 2012, Pages 47-49

  Hayashi, Yuya ^a   Mori, Yoshimasa ^a   Higashi, Taishi ^a   Motoyama, Keiichi ^a   Jono, Hirofumi ^a   Sah, Dinah W Y ^b   Ando, Yukio ^a   Arima, Hidetoshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

Conjugate; Cyclodextrin; Dendrimer; Familial amyloidotic polyneuropathy; Small interfering RNA; Transthyretin

Indexed keywords

ALPHA CYCLODEXTRIN DERIVATIVE; DENDRIMER; DRUG CARRIER; GLYCOSAMINOGLYCAN; PLASMID DNA; PREALBUMIN; PROTEIN VARIANT; SMALL INTERFERING RNA;

CONFERENCE PAPER; FAMILIAL AMYLOID POLYNEUROPATHY; GENE DELIVERY SYSTEM; GENE SILENCING; HUMAN; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; PLASMID; PRIORITY JOURNAL; RNA INTERFERENCE; RNA SEQUENCE; SYSTEMIC THERAPY;

ALPHA-CYCLODEXTRINS; AMYLOID NEUROPATHIES, FAMILIAL; ANIMALS; DENDRIMERS; HEPATOCYTES; HUMANS; PREALBUMIN; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84861422685     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.3109/13506129.2012.674581     Document Type: Conference Paper

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