Effects of testosterone administration and gonadectomy on incentive downshift and open field activity in rats

Physiology and Behavior

Volumn 106, Issue 5, 2012, Pages 657-663

  Justel, Nadia ^a   Ruetti, Eliana ^a   Bentosela, Mariana ^a   Mustaca, Alba E ^a   Papini, Mauricio R ^b  

^a ININCA (UBA CONICET)   (Argentina)

^b TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Anxiety; Consummatory extinction; Frustration; Gonadectomy; Incentive contrast; Open field activity; Rats; Testosterone

Indexed keywords

SUCROSE; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ARTICLE; CONSUMMATORY EXTINCTION; CONTROLLED STUDY; EJACULATION; EXPERIMENTAL TEST; GONADECTOMY; INCENTIVE DOWNSHIFT; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PRIORITY JOURNAL; RAT; REINFORCEMENT; TRANQUILIZING ACTIVITY;

ANDROGENS; ANIMALS; CONDITIONING, OPERANT; EXPLORATORY BEHAVIOR; GOALS; MALE; MOTIVATION; ORCHIECTOMY; RATS; RATS, WISTAR; TESTOSTERONE; TIME FACTORS;

EID: 84861390185     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2012.05.003     Document Type: Article

References (40)

1. Fernández-Guasti A., Roldán-Roldán G., Saldívar A. Reduction in anxiety after ejaculation in the rat. Behavioral Brain Research 1989, 32:23-29.
2. Freidin E., Kamenetzky G., Mustaca A.E. Anxiolytic-like effect of ejaculation upon frustration. Learn Behav 2005, 33:277-286.
3. Flaherty C.F., Grigson P.S., Lind S. Chlordiazepoxide and the moderation of the initial response to reward reduction. Q J Exp Psychol 1990, 42B:87-105.
4. Mustaca A.E., Bentosela M., Papini M.R. Consummatory successive negative contrast in mice. Learn Motiv 2000, 31:272-282.
5. Kamenetzky G., Mustaca A.E., Papini M.R. An analysis of the anxiolytic effects of ethanol on consummatory successive negative contrast. Av Psicol Latinoam 2008, 26:135-144.
6. Edinger K., Frye C. Sexual experience of male rats influences anxiety-like behavior and androgen levels. Physiol Behav 2007, 92:443-453.
7. Kamel F., Mock E.J., Wright W.W., Frankel A.I. Alterations in plasma concentrations of T, LH, and prolactin associated with mating in the male rat. Horm Behav 1975, 6:277-288.
8. Harding C.F., Feder H.H. Relation between individual differences in sexual behavior and plasma T levels in the guinea pig. Endocrinology 1976, 98:1198-1205.
9. Herndon J.G., Turner J.J., Collins D.C. Ejaculation is important for mating-induced T increases in male rhesus monkeys. Physiol Behav 1981, 27:873-877.
10. Bing O., Heilig M., Kakoulidis P., Sundblad C., Wiklund L., Eriksson E. High doses of testosterone increase anticonflict behavior in rat. Eur Neuropsycopharm 1998, 8:321-323.
11. Aikey J., Nyby J., Anmuth D., James P. Testosterone rapidly reduces anxiety in male house mice (Mus musculus). Horm Behav 2002, 42:448-460.
12. Bitran D., Kellog C., Hilvers R. Treatment with an anabolic-androgenic steroid affects anxiety-related behavior and alters the sensitivity of cortical GABAA receptors in the rat. Horm Behav 1993, 27:568-583.
13. Edinger K., Frye C. Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alfa-reduced metabolites in the hippocampus. Behav Neurosci 2004, 118:1352-1364.
14. Fernández-Guasti A., Martínez-Mota L. Orchidectomy sensitizes male rats to the action of diazepam on burying behavior latency: role of testosterone. Pharmacol Biochem Behav 2003, 75:473-479.
15. Edinger K., Frye C. Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5-alfa-reduced metabolites in the hippocampus. Psychoneuroendocrinology 2005, 30:418-430.
16. Edinger K., Frye C. Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats. Horm Behav 2006, 50:216-222.
17. Fernández-Guasti A., Martínez-Mota L. Anxiolytic-like actions of testosterone in the burying behavior test: Role of androgen and GABA-benzodiazepine receptors. Psyconeuroendocrinology 2005, 30:762-770.
18. Frye C., Edinger K. Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats. Pharmacol Biochem Behav 2004, 78:473-481.
19. Svensson A., Soderpalm B., Engel J. Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: implications for impulsive behavior. Pharmacol Biochem Behav 2000, 65:731-736.
20. Mustaca A.E., Freidin E., Papini M.R. Extinction of consummatory behavior in rats. Int J Comp Psychol 2002, 1:1-10.
21. Kamenetzky G., Mustaca A.E., Pedrón V., Cuenya L., Papini M.R. Ethanol facilitates consummatory extinction. Behav Processes 2009, 82:352-354.
22. Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 2003, 463:3-33.
23. Justel N., Ruetti E., Mustaca A.E., Papini M.R. Effects of pretraining treatment with testosterone on successive and anticipatory negative contrast. Physiol Behav 2012, 105:933-937.
24. Flaherty C.F., Coppotelli C., Potaki J. Effect of chlordiazepoxide on the response to repeated reductions in sucrose concentration in free-fed rats. Physiol Behav 1996, 60:1291-1298.
25. Papini M.R., Mustaca A.E., Bitterman M.E. Successive negative contrast in the consummatory responding of didelphid marsupials. Anim Learn Behav 1988, 16:53-57.
26. Riley E.A., Dunlap W.P. Successive negative contrast as a function of deprivation condition following shifts in sucrose concentration. Am J Psychol 1979, 92:59-70.
27. Flaherty C.F. Incentive relativity 1996, Cambridge University Press, Cambridge, UK.
28. Pellegrini S., Muzio R.N., Mustaca A.E., Papini M.R. Successive negative contrast after partial reinforcement in the consummatory behavior of rats. Learn Motiv 2004, 35:303-321.
29. Papini M.R., Pellegrini S. Scaling relative incentive value in consummatory behavior. Learn Motiv 2006, 37:357-378.
30. Mustaca A.E., Bentosela M., Ruetti E., Kamenetzky G., Cuenya L., Justel N., et al. Similitudes y discrepancias en dos modelos animales de frustración. Recientes desarrollos iberoamericanos en investigación en ciencias del comportamiento 2009, Vol. 2:921-940. CIIPME-CONICET, Buenos Aires, Argentina. M.C. Richaud de Minzi, E. Moreno (Eds.).
31. Wagner A. Effects of amount and percentage of reinforcement and number of acquisition trials on conditioning and extinction. J Exp Psychol 1961, 62:234-242.
32. Becker H.C., Flaherty C.F. Influence of ethanol on contrast in consummatory behaviour. Psychopharmacology 1982, 77:253-258.
33. Norris J.N., Daniel A.M., Papini M.R. Spontaneous recovery of consummatory behavior, but not of consummatory successive negative contrast. Learn Motiv 2008, 39:296-312.
34. Pellegrini S., Wood M.D., Daniel A.M., Papini M.R. Opioid receptors modulate recovery from consummatory successive negative contrast. Behav Brain Res 2005, 164:239-249.
35. Pellow S., Chopin P., File S.E., Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14:149-167.
36. Edinger K., Lee B., Frye C. Mnemonic effects of testosterone and its 5a-reduced metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacol Biochem Behav 2004, 78:559-568.
37. Frye C., Edinger K., Seliga A., Wawrzycki J. 5a-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 2004, 29:1019-1027.
38. Flaherty C.F., Grigson P.S., Rowan G.A. Chlordiazepoxide and the determinants of contrast. Anim Learn Behav 1986, 14:315-321.
39. Daniel A.M., Ortega L.A., Papini M.R. Role of the opioid system in incentive downshift situations. Neurobiol Learn Mem 2009, 92:439-450.
40. Norris J.N., Perez-Acosta A.M., Ortega L.A., Papini M.R. Naloxone facilitates appetitive extinction and eliminates escape from frustration. Pharmacol Biochem Behav 2009, 94:81-87.