Nitric oxide-donating statins: A new concept to boost the lipid-independent effects

Cardiovascular Research

Volumn 94, Issue 3, 2012, Pages 395-397

  Schirmer, Stephan H ^a   Werner, Christian M ^a   Laufs, Ulrich ^a   Bhm, Michael ^a  

^a Klinik fur Innere Medizin III   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOSORBIDE MONONITRATE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NCX 6560; NITRIC OXIDE; NITRIC OXIDE DONOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; HUMAN; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; HEPTANOIC ACIDS; NITRIC OXIDE; PYRROLES;

EID: 84861371520     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs148     Document Type: Review

References (16)

1. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-1135. (Pubitemid 28152885)
2. Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998;273:24266-24271. (Pubitemid 28435775)
3. Laufs U. Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur J Clin Pharmacol 2003;58:719-731. (Pubitemid 36399228)
4. Wassmann S, Werner N, Czech T, Nickenig G. Improvement of endothelial function by systemic transfusion of vascular progenitor cells. Circ Res 2006;99:e74-83. (Pubitemid 44556373)
5. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 2005;45: 89-118. (Pubitemid 40261799)
6. John S, Schneider MP, Delles C, Jacobi J, Schmieder RE. Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. Am Heart J 2005;149:473.
7. Gresele P, Migliacci R, Procacci A, De Monte P, Bonizzoni E. Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication. Thromb Haemost 2007;97:444-450. (Pubitemid 46437807)
8. Momi S, Monopoli A, Alberti PF, Falcinelli E, Corazzi T, Conti V et al. Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis. Cardiovasc Res 2012;94:428-438.
9. Venkatesh PK, Pattillo CB, Branch B, Hood J, Thoma S, Illum S et al. Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxidedependent pathway. Cardiovasc Res 2010;85:661-670.
10. Chen J, Kuhlencordt P, Urano F, Ichinose H, Astern J, Huang PL. Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice. Arterioscler Thromb Vasc Biol 2003;23:97-103. (Pubitemid 36091632)
11. Antoniades C, Bakogiannis C, Leeson P, Guzik TJ, Zhang MH, Tousoulis D et al. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling. Circulation 2011;124:335-345.
12. Laufs U, Adam O. Acute effects of statins. J Am Coll Cardiol 2012;59:71-73.
13. Muller S, Konig I, Meyer W, Kojda G. Inhibition of vascular oxidative stress in hypercholesterolemia by eccentric isosorbide mononitrate. J Am Coll Cardiol 2004;44: 624-631. (Pubitemid 39078190)
14. Djian JP, Maucci R, Guilmin L, Ferreira T, Pfister P. Abstract 14267: Ncx 6560, a novel nitric oxyde donating atorvastatin with a promising safety and efficacy profile: a randomised, double blind placebo and active control study. Circulation 2010;122: A14267.
15. Förstermann U, Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113:1708-1714.
16. Gielis JF, Lin JY, Wingler K, Van Schil PE, Schmidt HH, Moens AL. Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders. Free Radic Biol Med 2011;50: 765-776.