Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators

Journal of Ethnopharmacology

Volumn 141, Issue 3, 2012, Pages 989-996

  Bhujade, Arti M ^a   Talmale, Suhas ^a   Kumar, Naresh ^b   Gupta, Geetika ^b   Reddanna, P ^b   Das, Samar K ^b   Patil, M B ^a  

^a LAXMINARAYAN INSTITUTE OF TECHNOLOGY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

5 LOX; AA; Cissus quadrangularis; COX 1; COX 2; COX LOX inhibition; Cycloxygenase; HO 1; Inflammation; Nrf 2; Proinflammatory mediator

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONE; ALCOHOL; ARACHIDONATE 5 LIPOXYGENASE; CISSUS QUADRANGULARIS EXTRACT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HEME OXYGENASE 1; HEXANE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOXYGENASE INHIBITOR; METHANOL; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SILICON DIOXIDE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CISSUS QUADRANGULARIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; INFLAMMATION; NONHUMAN; PLANT STEM; SPECTROSCOPY; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; CELL PROLIFERATION; CISSUS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HEME OXYGENASE-1; LIPOXYGENASE INHIBITORS; MEMBRANE PROTEINS; MICE; NF-E2-RELATED FACTOR 2; PLANT EXTRACTS;

CISSUS QUADRANGULARIS;

EID: 84861332270     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.03.044     Document Type: Article

References (28)

1. M.K. Annukka, K. Emilia, J. Henna-Kaisa, N. Tarja, and Y.H. Seppo Levonen enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells The Journal of Nutrition 138 2008 1263 1268
2. P. Balasubramaniana, K. Jayalakshmib, N. Vidhyab, R. Prasada, A. Khaleefathullah, G. Kathiravana, and K. Rajagopala Antiviral activity of ancient system of ayurvedic medicinal plant Cissus quadrangularis linn. (Vitaceae) Journal of Basic Clinical Pharmacy 1 2010 37 40
3. R.A. Copeland, J.M. Williams, J. Giannaras, S. Nurnberg, M. Covington, and D. Pinto Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase Proceedings of the National Academy Science of the United States of America 91 1994 11202 11206
4. D.K. Deka, L.C. Lahon, J. Saikia, and A. Mukit Effect of Cissus quadrangularis in accelerating healing process of experimentally fractured radius-ulna of dog: a preliminary study Indian Journal of Pharmacology 26 1994 44 45
5. M. Daniel, I.R. Ana, S. Marta, D. Raquel, G. German, and A. Jawed Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/akt pathway and the nrf-2 transcription factor in response to the antioxidant phytochemical carnosol Journal of Biological Chemistry 279 2004 8919 8929
6. R.W. Egan, J. Paxton, and F.A. Kuehl Jr. Mechanism for irreversible self deactivation of prostaglandin synthetase Journal of Biological Chemistry 251 1976 7329 7335
7. M. Hemler, W.E. Lands, and W.L. Smith Purification of the cyclooxygenase that forms prostaglandins: demonstration of two forms of iron in the holoenzyme Journal of Biological Chemistry 251 1976 5575 5579
8. M. Jainu, and C. Shyamaladevi Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer - a comparative study with sucralfate Journal of Medicinal Food 7 2004 372 376
9. M. Jainu, and C.S. Shyamaladevi In vitro and in vivo evaluation of free radical scavenging potential of Cissus quadrangularis African Journal of Biomedical Research 8 2005 95 99
10. M. Jainu, and C. Shyamaladevi Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage Chemico-Biological Interactions 161 2006 262 270
11. M. Jainu, K. Vijaimohan, and K. Kannan Cissus quadrangularis l. extract attenuates chronic ulcer by possible involvement of polyamines and proliferating cell nuclear antigen Pharmacognsy Magazine 23 2010 225 233
12. N.D. Kashikar, and I. George Antibacterial activity of Cissus quadrangularis International Journal of Pharmaceutical Science 68 2006 245 247
13. A.P. Kulkarni Lipoxygenase - a versatile biocatalyst for biotransformation of endobiotics and xenobiotics Cell and Molecular Life Science 58 2001 1805 1825
14. J.M. Martel-Pelletier, D. Lajeunesse, P. Reboul, and J.P. Pelletier Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs Annual Rheumatological Disease 62 2003 501 509
15. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
16. J. Oben, D. Kuate, G. Agbor, C. Momo, and X. Talla The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome Lipid Health Disease 5 2006 1 7
17. J.E. Oben, D.M. Enyegue, G.I. Fomekong, Y.B. Soukontoua, and G.A. Agbor The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress Lipids in Health Disease 6 2007 1 8
18. W.R. Pagels, R.J. Sachs, L.J. Marnett, D.L. Dewitt, J.S. Day, and W.L. Smith Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes Journal of Biological Chemistry 258 1983 6517 6523
19. M. Pairet, L. Churchill, G. Trummlitz, and G. Engelhardt Differential inhibition of cyclooxygenase-1 (COX-1) and (COX-2) by NASAIDs: consequences on anti-inflammatory activity versus gastric and renal safety Inflammopharmacology 4 1996 61 70
20. Panda Journal of Research Ayurvedic Siddha 11 1990 7
21. D. Parisuthiman, W. Singhatanadgit, T. Dechatiwongse, and S. Koontongkaew Cissus quadrangularis extract enhances biomineralization through up-regulation of mapk-dependent alkaline phosphatase activity in osteoblasts In Vitro Cellular and Developmental Biology - Animal 45 2009 194 200
22. B.K. Potu, M.S. Rao, G.K. Nampurath, M.C. Rao, S.R. Nayak, and H. Thomas Anti-osteoporotic activity of the petroleum ether extract of Cissus quadrangularis linn. in ovariectomized wistar rats Chang Gung Medical Journal 33 2010 252 257
23. P. Reddanna, J. Whelan, K.R. Maddipati, and C.C. Reddy Purification of arachidonate 5-lipoxygenase from potato tubers Methods in Enzymology 187 1990 268 277
24. C.M. Reddy, V.B. Bhat, G. Kiranmai, M.N. Reddy, P. Reddanna, and K.M. Madyastha Selective inhibition of cyclooxygenase-2 by c-phycocyanin, a biliprotein from spirulina platensis Biochemical and Biophysical Research Communication 277 2000 599 603
25. A. Shirwaikar, S. Khan, and S. Malini Anti-osteoporotic effect of ethanol extract of Cissus quadrangularis linn on ovariectomized rat Journal of Ethnopharmacology 89 2003 245 250
26. H. Sharpa, J. Hollinsheada, B.B. Bartholomewa, J. Obenb, A. Watsona, and J.N. Robert Inhibitory effects of Cissus quadrangularis l. derived components on lipase, amylase and glucosidase activity in vitro Natural Product Communication 2 2007 817 822
27. A. Thakur, V. Jain, L. Hingorani, and K.S. Laddha Phytochemical studies on Cissus quadrangularis linn Pharmacognocy Research 1 2009 213 215
28. K.N. Udupa, G. Prasad, and S.P. Sen The effect of phytogenic anabolic steroid in the acceleration of fracture repairs Life Sciences 4 1965 317 327