CLopidogrel trial in patients with elective percutaneous coronary intervention for stable angina and old myocardial infarction (CLEAN): Safety and efficacy of clopidogrel compared to ticlopidine in Japanese patients

International Heart Journal

Volumn 53, Issue 2, 2012, Pages 91-101

  Isshiki, Takaaki ^a   Kimura, Takeshi ^b   Ueno, Takafumi ^c   Nakamura, Masato ^d   Igarashi, Keiichi ^e   Yokoi, Hiroyoshi ^f   Kobayashi, Masahiko ^g   Ikari, Yuji ^h  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOHO UNIVERSITY OHASHI MEDICAL CENTER   (Japan)

^e Hokkaido Social Insurance Hospital   (Japan)

^f KOKURA MEMORIAL HOSPITAL   (Japan)

^g Sanofi Aventis KK ^*  (Japan)

^h TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Coronary artery disease; Dual antiplatelet therapy; Major adverse cardiac and cerebrovascular events; Major adverse cardiac events; Safety of clopidogrel; Stents

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; TICLOPIDINE;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BLEEDING; BLOOD DISEASE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HEART INFARCTION; HUMAN; INCIDENCE; JAPANESE; LIVER FUNCTION; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OLD HEART INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; Q WAVE; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; RISK BENEFIT ANALYSIS; RISK REDUCTION; SIDE EFFECT; STABLE ANGINA PECTORIS; STENT THROMBOSIS; TREATMENT DURATION;

ADULT; AGED; ANGINA, STABLE; ANGIOPLASTY, BALLOON, CORONARY; ASPIRIN; COMBINED MODALITY THERAPY; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; RISK ASSESSMENT; TICLOPIDINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84861325259     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.53.91     Document Type: Article

References (20)

1. Joint Research Group in year 2002-2003. Guidelines for management of anticoagulant and antiplatelet therapy in cardio-vascular disease (JCS2004). Circ J 2004; 68 Suppl IV: 1153-219. (Japanese)
2. Paradiso-Hardy FL, Angelo CM, Lanctôt KL, Cohen EA. Hematologic dyscrasia associated with ticlopidine therapy: evidence for causality. CMAJ 2000; 163: 1441-8.
3. Smith SC Jr, Dove JT, Jacobs AK, et al. ACC/AHA guidelines for percutaneous coronary interventions (revision of the 1993 PTCA guidelines)--executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J Am Coll Cardiol 2001; 37: 2215-39.
4. Mizushima M, Iwata N, Fujimoto TT, Ishikawa K, Fujimura K. Patient characteristics in ticlopidine hydrochloride-induced liver injury: Case-control study. Hepatol Res 2005; 33: 234-40.
5. Fox KA, Mehta SR, Peters R, et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation 2004; 110: 1202-8.
6. Fukuuchi Y, Tohgi H, Okudera T, et al. A randomized, doubleblind study comparing the safety and efficacy of clopidogrel ver sus ticlopidine in Japanese patients with noncardioembolic cerebral infarction. Cerebrovasc Dis 2008; 25: 40-9.
7. King SB 3rd, Smith SC Jr, Hirshfeld JW Jr, et al. 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing Committee. Circulation 2008; 117: 261-95.
8. Kimura T, Morimoto T, Nakagawa Y, et al. Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation. Circulation 2009; 119: 987-95.
9. Nakagawa Y, Kimura T, Morimoto T, et al. Incidence and risk factors of late target lesion revascularization after sirolimus-eluting stent implantation (3-year follow-up of the j-Cypher Registry). Am J Cardiol 2010; 106: 329-36.
10. Bertrand ME, Rupprecht HJ, Urban P, Gershlick AH, CLASSICS Investigators. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation 2000; 102: 624-9.
11. Taniuchi M, Kurz HI, Lasala JM. Randomized comparison of ticlopidine and clopidogrel after intracoronary stent implantation in a broad patient population. Circulation 2001; 104: 539-43.
12. Müller C, Büttner HJ, Petersen J, Roskamm H. A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents. Circulation 2000; 101: 590-3.
13. Calver AL, Blows LJ, Harmer S, et al. Clopidogrel for prevention of major cardiac events after coronary stent implantation: 30-day and 6-month results in patients with smaller stents. Am Heart J 2000; 140: 483-91.
14. Moussa I, Oetgen M, Roubin G, et al. Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation 1999; 99: 2364-6.
15. Berger PB. Clopidogrel instead of ticlopidine after coronary stent placement: is the switch justified? Am Heart J 2000; 140: 354-8.
16. Bhatt DL, Bertrand ME, Berger PB, et al. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting. J Am Coll Cardiol 2002; 39: 9-14.
17. Berger PB, Bell MR, Rihal CS, et al. Clopidogrel versus ticlopidine after intracoronary stent placement. J Am Coll Cardiol 1999; 34: 1891-4.
18. Mishkel GJ, Aguirre FV, Ligon RW, Rocha-Singh KJ, Lucore CL. Clopidogrel as adjunctive antiplatelet therapy during coronary stenting. J Am Coll Cardiol 1999; 34: 1884-90.
19. Silber S, Albertsson P, Avilés FF, et al. Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 2005; 26: 804-47.
20. Wijns W, Kolh P, Danchin N, et al. Guidelines on myocardial revascularization. Eur Heart J 2010; 31: 2501-55.