Lactone metabolite common to the carcinogens dioxane, diethylene glycol, and N-nitrosomorpholine: Aqueous chemistry and failure to mediate liver carcinogenesis in the F344 rat

Chemical Research in Toxicology

Volumn 25, Issue 5, 2012, Pages 1022-1028

  Koissi, Niangoran ^a   Shah, Niti H ^a   Ginevan, Brandon ^a   Eck, William S ^b   Roebuck, Bill D ^c   Fishbein, James C ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b Army Institute of Public Health   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIOXAN 2 ONE; ACETONITRILE; AFLATOXIN B1; BUFFER; CARBOXYLIC ACID; DIETHYLENE GLYCOL; DIOXANE DERIVATIVE; DRUG METABOLITE; LACTONE; NITROSOMORPHOLINE; PROTON; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; FISCHER 344 RAT; IONIC STRENGTH; LIVER CARCINOGENESIS; MALE; NONHUMAN; PH; PKA; RAT; SOLVOLYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CARCINOGENS; DIOXANES; ETHYLENE GLYCOLS; LACTONES; LIVER; LIVER NEOPLASMS; MALE; NITROSAMINES; RATS; RATS, INBRED F344;

RATTUS;

EID: 84861310355     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3000076     Document Type: Article

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