Successful treatment of septic shock and respiratory failure due to leptospirosis and scrub typhus coinfection with penicillin, levofloxacin, and activated protein C

Journal of Microbiology, Immunology and Infection

Volumn 45, Issue 3, 2012, Pages 251-254

  Wei, Yu Feng ^a   Chiu, Chien Tung ^a   Lai, Yung Fa ^a   Lai, Chung Hsu ^a,b   Lin, Hsi Hsun ^a,c  

^a E DA HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Human recombinant activated protein C; Leptospirosis; Scrub typhus; Septic shock

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATININE; DROTRECOGIN; LEVOFLOXACIN; PENICILLIN G;

ABNORMAL RESPIRATORY SOUND; ADD ON THERAPY; ADULT; AGGLUTINATION TEST; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ARTIFICIAL VENTILATION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD EXAMINATION; CARDIOMEGALY; CASE REPORT; CONVALESCENCE; COUGHING; CREATININE BLOOD LEVEL; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; ELECTROCARDIOGRAPHY; ENDEMIC DISEASE; ENDOTRACHEAL INTUBATION; EYE JAUNDICE; FEVER; GRAM NEGATIVE INFECTION; HEADACHE; HEMODYNAMICS; HOSPITALIZATION; HUMAN; HYPOXEMIA; IMMUNOASSAY; INTENSIVE CARE; INTENSIVE CARE UNIT; KIDNEY FUNCTION; LEPTOSPIROSIS; LYMPHADENOPATHY; MALE; METABOLIC ACIDOSIS; MICROSCOPIC AGGLUTINATION TEST; MIXED INFECTION; MULTIPLE ORGAN FAILURE; MYALGIA; OLIGURIA; OXYGEN SATURATION; PHYSICIAN; RESPIRATORY FAILURE; RICKETTSIOSIS; SCRUB TYPHUS; SEPTIC SHOCK; SEROLOGY; SINUS TACHYCARDIA; SPUTUM; SURVIVAL TIME; THORAX RADIOGRAPHY; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL; URINALYSIS;

ANTI-INFECTIVE AGENTS; ANTIBODIES, BACTERIAL; HUMANS; LEPTOSPIRA; LEPTOSPIROSIS; MALE; MIDDLE AGED; OFLOXACIN; ORIENTIA TSUTSUGAMUSHI; PENICILLINS; PROTEIN C; RESPIRATORY INSUFFICIENCY; SCRUB TYPHUS; SHOCK, SEPTIC;

EID: 84861235449     PISSN: 16841182     EISSN: 19959133     Source Type: Journal    
DOI: 10.1016/j.jmii.2011.09.015     Document Type: Article

References (19)

1. Levett P.N. Leptospirosis. Clin Microbiol Rev 2001, 14:296-326.
2. Jeong Y.J., Kim S., Wook Y.D., Lee J.W., Kim K.I., Lee S.H. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 2007, 27:161-172.
3. Chen Y.S., Cheng S.L., Wang H.C., Yang P.C. Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange. J Formos Med Assoc 2007, 106:S1-S6.
4. Lee C.H., Liu J.W. Coinfection with leptospirosis and scrub typhus in Taiwanese patients. Am J Trop Med Hyg 2007, 77:525-527.
5. Lu P.L., Tseng S.H. Fatal septicemic melioidosis in a young military person possibly co-infected with Leptospira interrogans and Orientia tsutsugamushi. Kaohsiung J Med Sci 2005, 21:173-178.
6. Wang N.C., Ni Y.H., Peng M.Y., Chang F.Y. Acute acalculous cholecystitis and pancreatitis in a patient with concomitant leptospirosis and scrub typhus. J Microbiol Immunol Infect 2003, 36:285-287.
7. Watt G., Jongsakul K., Suttinont C. Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. Am J Trop Med Hyg 2003, 68:89-91.
8. Levi M. Activated protein C in sepsis: a critical review. Curr Opin Hematol 2008, 15:481-486.
9. Srinivas R., Agarwal R., Gupta D. Severe sepsis due to severe falciparum malaria and leptospirosis co-infection treated with activated protein C. Malar J 2007, 6:42.
10. Chou Y.L., Chen C.S., Liu C.C. Leptospirosis in Taiwan, 2001-2006. Emerg Infect Dis 2008, 14:856-857.
11. Lai C.H., Huang C.K., Chen Y.H., Chang L.L., Weng H.C., Lin J.N., et al. Epidemiology of acute Q fever, scrub typhus, and murine typhus, and identification of their clinical characteristics compared to patients with acute febrile illness in southern taiwan. J Formos Med Assoc 2009, 108:367-376.
12. Lai C.H., Huang C.K., Weng H.C., Chung H.C., Liang S.H., Lin J.N., et al. The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. Int J Infect Dis 2009, 13:387-393.
13. Tsay R.W., Chang F.Y. Serious complications in scrub typhus. J Microbiol Immunol Infect 1998, 31:240-244.
14. Tantibhedhyangkul W., Angelakis E., Tongyoo N., Newton P.N., Moore C.E., Phetsouvanh R., et al. Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi. Int J Antimicrob Agents 2010, 35:338-341.
15. Maurin M., Raoult D. Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii. J Antimicrob Chemother 1997, 39:725-730.
16. Tsai C.C., Lay C.J., Wang C.L., Ho Y.H., Wang L.S., Chen L.K. Levofloxacin versus tetracycline antibiotics for the treatment of scrub typhus. Int J Infect Dis 2010, 14:e62-e67.
17. Watt G., Chouriyagune C., Ruangweerayud R., Watcharapichat P., Phulsuksombati D., Jongsakul K., et al. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Lancet 1996, 348:86-89.
18. Seong S.Y., Choi M.S., Kim I.S. Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect 2001, 3:11-21.
19. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327.