Fetuin-A serum levels are not correlated to kidney function in long-lived subjects

Clinical Biochemistry

Volumn 45, Issue 9, 2012, Pages 637-640

  Bellia, Chiara ^a   Tomaiuolo, Rossella ^b,d   Caruso, Antonietta ^a   Sasso, Bruna Lo ^a   Zarrilli, Federica ^b,e   Carru, Ciriaco ^c   Deiana, Maria ^c   Zinellu, Angelo ^c   Pinna, Sara ^c   Castaldo, Giuseppe ^b,d   Deiana, Luca ^c   Ciaccio, Marcello ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF MOLISE   (Italy)

Author keywords

AHSG; Cystatin C; Elderly; Fetuin A; Kidney disease

Indexed keywords

CYSTATIN C; FETUIN A; SERINE; THREONINE;

AGE DISTRIBUTION; AGED; AGING; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NEPHELOMETRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SENESCENCE;

AGED, 80 AND OVER; AGING; ALPHA-2-HS-GLYCOPROTEIN; CALCINOSIS; CYSTATIN C; FEMALE; GENE EXPRESSION; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84861229584     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.02.024     Document Type: Article

References (26)

1. Schafer C., Heiss A., Shwarz A., Westenfeld R., Ketteler M., Floege J., et al. The serum protein α2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Inv 2003, 112:357-366.
2. Schinke T., Amendt C., Trindl A., Pöschke O., Müller-Esterl W., Jahnen-Dechent W. The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells: a possible role in mineralization and calcium homeostasis. J Biol Chem 1996, 271:20789-20796.
3. Westenfeld R., Schafer C., Kruger T., Haarmann C., Schurgers L.J., Reutelingsperger C., et al. Fetuin-A protects against atherosclerotic calcification in CKD. J Am Soc Nephrol 2009, 20:1264-1274.
4. Koos R., Brandenburg V., Mahnken A.H., Mühlenbruch G., Stanzel S., Günther R.W., et al. Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients. Eur Heart J 2009, 30:2054-2061.
5. Shastri S., Tighiouart H., Katz R., Rifkin D.E., Fried L.F., Shlipak M.G., et al. Chronic kidney disease in octogenarians. Clin J Am Soc Nephrol 2011, 6:1410-1417.
6. Cecelia M., Jiang B., Bevan L., Frost M.L., Spector T.D., Chowienczyk P.J. Arterial stiffening relates to arterial calcification but not to noncalcified atheroma in women. A twin study. J Am Coll Cardiol 2011, 57:1480-1486.
7. Jono S., Shioi A., Ikari Y., Nishizawa Y. Vascular calcification in chronic kidney disease. J Bone Miner Metab 2006, 24:176-181.
8. Osawa M., Yuasa I., Kitano T., Henke J., Kaneko M., Udono T., et al. Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene. Ann Hum Genet 2001, 65:27-34.
9. Stenvinkel P., Wang K., Qureshi A.R., Axelsson J., Pecoits-Filho R., Gao P., et al. Low fetuin-A levels are associated with cardiovascular death: impact of variation in the gene encoding fetuin. Kidney Int 2005, 67:2383-2392.
10. Ferguson M.A., Waikar S.S. Established and Emerging Markers of Kidney Function. Clin Chem 2012, (Feb 6).
11. Deiana L., Ferrucci L., Pes G.M., Carru C., Delitala G., Ganau A., et al. AKEntAnnos. The Sardinia study of extreme longevity. Aging 1999, 11(3):142-149.
12. Baggio G. Occurrence of chronic disease and their impact on physical disability over the whole spectrum of aging: from 65 to over 100 years of age. Z Gerontol Geriatr 1999, 32:420-424.
13. Hoek F.J., Kemperman F.A.W., Krediet R.T. A comparison between cystatin C, plasma creatinine and the Cockroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant 2003, 18:2024-2031.
14. Hending D., Schulz V., Arndt M., Szliska C., Kleesiek K., Götting C. Role of serum Fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum. Clin Chem 2006, 52:227-234.
15. Cozzolino M., Biondi M.L., Galassi A., Gallieni M., d'Eril G.V., Brancaccio D. Gene polymorphisms and serum alpha-2-Heremans-Schmid levels in Italian haemodialysis patients. Am J Nephrol 2007, 27:639-642.
16. Ketteler M., Bongartz P., Westenfeld R., Wildberger J.E., Mahnken A.H., Böhm R., et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 2003, 361:827-833.
17. Ciaccio M., Bivona G., Di Sciacca R., Iatrino R., Di Natale E., Li Vecchi M., et al. Changes in serum fetuin-A and inflammatory markers levels in end-stage renal disease (ESRD): effect of a single session haemodialysis. Clin Chem Lab Med 2008, 46(2):212-214.
18. El-Shehaby A.M., Zakaria A., El-Khatib M., Mostafa N. Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients. Scand J Clin Lab Invest 2010, 70:575-582.
19. Goustin A.S., Abou-Samra A.B. The "thrifty" gene encoding Ahsg/Fetuin-A meets the insulin receptor: insights into the mechanism of insulin resistance. Cell Signal 2011, 23:980-990.
20. Ix J.H., Wassel C.L., Chertow G.M., Koster A., Johnson K.C., Tylavsky F.A., et al. Fetuin-A and change in body composition in older persons. J Clin Endocrinol Metab 2009, 94:4492-4498.
21. Osawa M., Tian W., Horiuchi H., Kaneko M., Umetsu K. Association of α2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. Hum Genet 2005, 116:146-151.
22. Shlipak M.G., Katz R., Kestenbaum B., Fried L.F., Newman A.B., Siscovick D.S., et al. Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C. Am J Nephrol 2009, 30:171-178.
23. Fliser D. Assessment of renal function in elderly patients. Curr Opin Nephrol Hypertens 2008, 17:604-608.
24. Christensson A., Elmstahl S. Estimation of the age-dependent decline of glomerular filtration rate from formulas based on creatinine and cystatin C in the general elderly population. Nephron Clin Pract 2011, 117:c40-c50.
25. Dharnidharka V., Kwon C., Stevens G. Serum Cystatin C is superior to Serum Creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002, 40:221-226.
26. Ix J.H., Chertow G.M., Shlipak Mg, Brandenburg V.M., Ketteler M., Whooley M.A. Fetuin-A and kidney function in persons with coronary artery disease-data from the heart and soul study. Nephrol Dial Transplant 2006, 21:2144-2151.