The influence of HPMC viscosity as FRC parameter on the release of low soluble drug from hydrophylic matrix tablets

Pharmaceutical Development and Technology

Volumn 18, Issue 2, 2013, Pages 343-347

  Novak, S Devjak ^a   Kuhelj, V ^a   Vrecer F ^a   Baumgartner, S ^b  

^a KRKA D D   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Apparent viscosity; Dissolution testing; Functionality related characteristics (FRC); Hydroxypropyl methylcellulose (HPMC)

Indexed keywords

DICLOFENAC; HYDROXYPROPYLMETHYLCELLULOSE;

ARTICLE; DRUG RELEASE; DRUG SOLUBILITY; FUNCTIONALITY RELATED CHARACTERISTIC; MATRIX TABLET; MOLECULAR WEIGHT; PHYSICAL PARAMETERS; PRIORITY JOURNAL; VISCOSITY;

CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; EXCIPIENTS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHYLCELLULOSE; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TABLETS; VISCOSITY;

EID: 84861222181     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2011.609991     Document Type: Article

References (10)

1. The European Pharmacopeia, 6th. Edition, Council of Europe, Strasbourg 2008
2. Medicines Complete: Pharmaceutical excipients (database on the internet). London, Washington: Pharmaceutical Press and American Pharmacists Association; 2010. p. 1-13
3. Baumgartner S, Planinšek O, Srčič S, Kristl J. Analysis of surface properties of cellulose ethers and drug release from their matrix tablets. Eur J Pharm Sci 2006;27:375-383
4. Herder J, Adolfsson A, Larsson A. Initial studies of water granulation of eight grades of hypromellose (HPMC). Int J Pharm 2006;313:57-65
5. Bin C, Joshi SC, Lam YC. Bio-fluid uptake and release of indomethacin of direct-compressed HPMC tablets. Carbohydrate Polymers 2009;75:282-286
6. Baumgartner S, Kristl J, Peppas NA. Network structure of cellulose ethers used in pharmaceutical applications during swelling and at equilibrium. Pharm Res 2002;19:1084-1090 (Pubitemid 34984990)
7. Campos-Aldrete ME, Villafuerte-Robles L. Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets. Eur J Pharm Biopharm 1997;43:173-178 (Pubitemid 28298798)
8. Viridén A, Larsson A, Wittgren B. The effect of substitution pattern of HPMC on polymer release from matrix tablets. Int J Pharm 2010;389:147-156
9. Colombo P, Santi P, Bettini R, Brazel SB, Peppas NA. (2000) Drug release from swelling controlled systems. In: Wise, D. L, Ed. Handbook of Pharmaceutical Conrtolled Release Technology. Marcel Dekker, NY, 183-209
10. Baumgartner S, Pavli M, Kristl J. Effect of calcium ions on the gelling and drug release characteristics of xanthan matrix tablets. Eur J Pharm Biopharm 2008;69:698-707