β-microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium- and pH-dependent mechanism

PLoS Pathogens

Volumn 8, Issue 4, 2012, Pages

  Hägerwall, Anneli M L Edström ^a   Rydengård, Victoria ^a   Fernlund, Per ^b   Mörgelin, Matthias ^a   Baumgarten, Maria ^a   Cole, Alexander M ^c   Malmsten, Martin ^d   Kragelund, Birthe B ^e   Sørensen, Ole E ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^d UPPSALA UNIVERSITY   (Sweden)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA MICROSEMINOPROTEIN; CALCIUM; ERGOSTEROL; LIPOSOME; ANTIFUNGAL AGENT; BETA-MICROSEMINOPROTEIN; PROSTATIC SECRETORY PROTEIN;

ACIDIFICATION; ACIDITY; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; COITUS; COLONY FORMING UNIT; CONTROLLED STUDY; DIMERIZATION; DRUG ANTAGONISM; DRUG MECHANISM; EXPERIMENTAL PIG; FEMALE; FUNGICIDAL ACTIVITY; FUNGUS TRANSMISSION; HUMAN; HUMAN TISSUE; LYSIS; MALE; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; SCANNING ELECTRON MICROSCOPY; SEMEN ANALYSIS; SEMINAL PLASMA; SEXUAL TRANSMISSION; VAGINA FLORA; CANDIDIASIS; CHEMISTRY; CLINICAL TRIAL; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MULTICENTER STUDY; PATHOGENICITY; PROTEIN TERTIARY STRUCTURE; SPERM; VAGINA;

CANDIDA; CANDIDA ALBICANS; FUNGI; SUS;

ANTIFUNGAL AGENTS; CALCIUM; CANDIDA ALBICANS; CANDIDIASIS; COITUS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNITY, INNATE; LIPOSOMES; MALE; PROSTATIC SECRETORY PROTEINS; PROTEIN STRUCTURE, TERTIARY; SEMEN; VAGINA;

EID: 84861216390     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002625     Document Type: Article

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