Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestine

PLoS Pathogens

Volumn 8, Issue 3, 2012, Pages

  Couesnon, Aurélie ^a   Molgó, Jordi ^b   Connan, Chloé ^a   Popoff, Michel R ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; CELL SURFACE RECEPTOR; HALF C TERMINAL DOMAIN OF HEAVY CHAIN OF BOTULINUM NEUROTOXIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CRYPT CELL; HUMAN; HUMAN CELL; ILEUM; INTESTINE CONTRACTION; MALE; MOUSE; MYENTERIC PLEXUS; NONHUMAN; SEROTONINERGIC NERVE CELL; SUBMUCOSA; ANIMAL; DRUG EFFECT; INTESTINE CELL; METABOLISM; MOUSE STRAIN; NEUROSECRETION; NEUROSECRETORY CELL; PATHOLOGY; PROTEIN TRANSPORT;

ANIMALS; BOTULINUM TOXINS, TYPE A; CHOLINERGIC NEURONS; ENTEROCYTES; ILEUM; MALE; MICE; MICE, INBRED STRAINS; NEUROENDOCRINE CELLS; NEUROSECRETORY SYSTEMS; PROTEIN TRANSPORT;

EID: 84861215299     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002583     Document Type: Article

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