Genomic loss of patient-specific HLA in acute myeloid leukemia relapse after well-matched unrelated donor HSCT

Blood

Volumn 119, Issue 20, 2012, Pages 4813-4815

  Toffalori, Cristina ^a   Cavattoni, Irene ^b   Deola, Sara ^b   Mastaglio, Sara ^a   Giglio, Fabio ^a   Mazzi, Benedetta ^a   Assanelli, Andrea ^a   Peccatori, Jacopo ^a   Bordignon, Claudio ^a   Bonini, Chiara ^a   Cortelazzo, Sergio ^b   Ciceri, Fabio ^a   Fleischhauer, Katharina ^a   Vago, Luca ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Azienda Sanitaria dell'Alto Adige   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; HLA ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASIA; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PATIENT; CANCER RELAPSE; CASE REPORT; CHROMOSOME 6P; CONSOLIDATION CHEMOTHERAPY; DONOR LYMPHOCYTE INFUSION; FEMALE; GENE MUTATION; GENOME ANALYSIS; HAPLOIDY; HAPLOTYPE; HUMAN; KARYOTYPE; LETTER; MOLECULAR TYPING; MYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; SALVAGE THERAPY; SINGLE NUCLEOTIDE POLYMORPHISM; UNIPARENTAL DISOMY; UNRELATED DONORS;

EID: 84861215240     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-02-411686     Document Type: Letter

References (5)

1. Vago L, Perna SK, Zanussi M, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med. 2009;361(5):478-488.
2. Villalobos IB, Takahashi Y, Akatsuka Y, et al. Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. Blood. 2010;115(15):3158-3161.
3. Waterhouse M, Pfeifer D, Pantic M, Emmerich F, Bertz H, Finke J. Genomewide profiling in AML patients relapsing after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2011;17(10):1450-1459.
4. Baldomero H, Gratwohl M, Gratwohl A, et al. The EBMT activity survey 2009: trends over the past 5 years. Bone Marrow Transplant. 2011;46(4):485-501.
5. Cloos J, Goemans BF, Hess CJ, et al. Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples. Leukemia. 2006; 20(7):1217-1220. (Pubitemid 43905824)