Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17812-17822

  O'Shea, Patrick J ^a,b   Kim, Dong Wook ^a   Logan, John G ^b   Davis, Sean ^a   Walker, Robert L ^a   Meltzer, Paul S ^a   Cheng, Sheue Yann ^a   Williams, Graham R ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DEVELOPMENT; BONE FORMATION; CANONICAL WNT SIGNALING; CHONDROCYTES; GAIN-OF FUNCTION; IN-SITU HYBRIDIZATION; NEGATIVE MUTANTS; OSTEOBLASTIC CELLS; PRIMARY OSTEOBLASTS; PROTEASOMAL DEGRADATION; PROTEIN SIGNALING; SIGNALING PATHWAYS; SKELETAL DEVELOPMENT; TARGET GENE EXPRESSION; THYROID HORMONE RECEPTOR; THYROID HORMONES; WILD TYPES; WNT PATHWAY;

ACTIVATION ANALYSIS; BONE; DEGRADATION; GENE EXPRESSION; HORMONES;

MAMMALS;

BETA CATENIN; LIOTHYRONINE; THYROID HORMONE RECEPTOR BETA; WNT PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HORMONE ACTION; IN SITU HYBRIDIZATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYROID HORMONE RECEPTOR BETA GENE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BETA CATENIN; MICE; MICE, MUTANT STRAINS; MUTATION; OSTEOBLASTS; OSTEOGENESIS; PITUITARY GLAND; PROTEIN STABILITY; THYROID HORMONE RECEPTORS BETA; TRIIODOTHYRONINE; WNT SIGNALING PATHWAY;

MUS;

EID: 84861206346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311464     Document Type: Article

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