HIF-1α, VEGF and WT-1 are protagonists in bilateral primary angiosarcoma of breast: A case report and review of literature

International Journal of Clinical and Experimental Pathology

Volumn 5, Issue 3, 2012, Pages 247-253

  Al Salam, Suhail ^a   Balalaa, Nahed ^b   Faour, Issam ^b   Akhter, Sayed ^c   Alashari, Mouied ^c  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c TAWAM HOSPITAL   (United Arab Emirates)

Author keywords

Angiosarcoma; Breast; HIF 1 ; VEGF; WT 1

Indexed keywords

HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TUMOR MARKER; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN; WT1 PROTEIN;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ANGIOSARCOMA; ARTICLE; BIOPSY; BREAST TUMOR; CASE REPORT; CHEMISTRY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHADENECTOMY; MASTECTOMY; METABOLISM; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATION; REOPERATION; TREATMENT OUTCOME;

BIOPSY; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; FEMALE; HEMANGIOSARCOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LYMPH NODE EXCISION; MASTECTOMY; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; RADIOTHERAPY, ADJUVANT; REOPERATION; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WT1 PROTEINS;

EID: 84861205846     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. McGowan TS, Cummings BJ, O'Sullivan B, Catton CN, Miller N, Panzarella T. An analysis of 78 breast sarcoma patients without distant metastases at presentation. Int J Radiat Oncol Biol Phys 2000; 46: 383-390.
2. Chen KT, Kirkegaard DD, Bocian JJ: Angiosarcoma of the breast. Cancer 1980; 46: 368-371.
3. van Geel AN, den Bakker MA. Bilateral angiosarcoma of the breast in a fourteen-year-old child. Rare Tumors 2009; 28: e38.
4. Zhou SA, Wei H, Ding K. A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast. Breast Care (Basel) 2009; 4: 405-407.
5. Marchant LK, Orel SG, Perez-Jaffe LA, Reynolds C, Schnall MD. Bilateral angiosarcoma of the breast on MR imaging. AJR Am J Roentgenol 1997; 169: 1009-1010.
6. Khoshim M, Sadiq S, Ajarim D, Jamjoom ZA. Bilateral angiosarcoma of the breast-a case report. Jpn J Surg 1991; 21: 693-695.
7. Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 2007; 19: 2003-2012.
8. Greijer AE, van der Groep P, Kemming D, Shvarts A, Semenza GL, Meijer GA, van de Wiel MA, Belien JA, van Diest PJ, van der Wall E. Upregulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol 2005; 206: 291-304.
9. Dohi S, Ohno S, Ohno Y, Kyo S, Soma G, Sugiyama H, Inoue M. WT1 expression correlates with angiogenesis in endometrial cancer tissue. Anticancer Res 2010; 30: 3187-3192.
10. Cancellieri A, Eusebi V, Mambelli V, Ricotti G, Gardini G, Pasquinelli G. Well-differentiated angiosarcoma of the skin following radiotherapy. Report of two cases. Pathol Res Pract 1991; 187: 301-306.
11. Marcon I, Collini P, Casanova M, Meazza C, Ferrari A. Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. Pediatr Hematol Oncol 2004; 21: 23-26.
12. Elli M, Can B, Ceyhan M, Pinarli FG, Dagdemir A, Ayyildiz HS, Gürsel B, Dagçinar A. Intrathoracic malignant peripheral nerve sheath tumor with angiosarcoma in a child with NF1. Tumori 2007; 93: 641-644.
13. Kirchner SG, Heller RM, Kasselberg AG, Greene HL. Infantile hepatic hemangioendothelioma with subsequent malignant degeneration. Pediatr Radiol 1981; 11: 42-45.
14. Boucher LD, Swanson PE, Stanley MW, Silverman JF, Raab SS, Geisinger KR. Cytology of angiosarcoma. Findings in fourteen fine-needle aspiration biopsy specimens and one pleural fluid specimen. Am J Clin Pathol 2000; 114: 210-219.
15. Kirschner KM, Sciesielski LK, Scholz H. Wilms' tumour protein Wt1 stimulates transcription of the gene encoding vascular endothelial cadherin. Pflugers Arch 2010; 460: 1051-1061.
16. Gennaro M, Valeri B, Casalini P, Carcangiu ML, Gronchi A, Conti AR, Agresti R, Greco M. Angiosarcoma of the breast and vascular endothelial growth factor receptor. Tumori 2010; 96: 930-935.
17. Brentani MM, Pacheco MM, Oshima CT. Steroid receptor in breast angiosarcoma. Cancer 1983; 51: 2105-2111.
18. Staingaszner LC, Enzinger FM, Taylor HB. Hemangiosarcoma of the breast. Cancer 1965; 18: 352-361.
19. Chen KTK, Kirkengaard DD, Bocian JJ. Angiosarcoma of the breast. Cancer 1981; 46: 368-371.
20. Kumar A, Gupta S, Chopra P, Sharma LK. Bilateral angiosarcoma of the breast: an overview. Aust N Z J Surg 1990; 60: 341-345.
21. Liberman L, Dershaw DD, Kaufman RJ, Rosen PP. Angiosarcoma of the breast Radiology 1992; 183: 649-654.
22. Bernathova M, Jaschke W, Pechlahner C, Zelger B, Bodner G. Primary angiosarcoma of the breast associated with Kasabach-Merritt syndrome during pregnancy. Breast 2006; 15: 255-258.
23. Donnell RM, Rosen PP, Lieberman PH, Kaufman RJ, Kay S, Braun DW Jr, Kinne DW. Angiosarcoma and other vascular tumors of the breast. Am J Surg Path 1981; 5: 629-642.
24. Donnell RM, Rosen PP, Lieberman PH, Kaufman RJ, Kay S, Braun DW Jr, Kinne DW. Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat 2007; 105: 81-85.
25. Tiwary SK, Singh MK, Prasad R, Sharma D, Kumar M, Shukla VK. Primary angiosarcoma of the breast. Surgery 2007; 141: 821-822.
26. Fernandez Ortega A, Gil Gil JM, Urruticoetxea A, Serra Payró JM. Angiosarcoma of the breast. Two cases following breast conserving treatment for invasive carcinoma. Clin Transl Oncol 2006; 8: 536-539.
27. Nascimento AF, Raut CP, Fletcher CD. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol 2008; 32: 1896-1904.
28. Silverman LR, Deligdisch L, Mandeli J, Greenspan EM. Chemotherapy for angiosarcoma of the breast: case report of 30 year survival and analysis of the literature. Cancer Invest 1994; 12: 145-155.