Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 5, 2012, Pages 796-800

  Zhao, Xiaoyan ^a   Zhang, Jie ^b   Tong, Nannan ^a   Chen, Youran ^a   Luo, Yonghuang ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b CHONGQING THREE GORGES UNIVERSITY   (China)

Author keywords

Berberine; Doxorubicin; Hepatotoxicity; Serum parameter

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BERBERINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL INFILTRATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; LIVER CONGESTION; LIVER FIBROSIS; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BERBERINE; BODY WEIGHT; COPTIS; DOXORUBICIN; DRUG-INDUCED LIVER INJURY; FEMALE; LIVER; MALE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RANDOM ALLOCATION;

EID: 84861203702     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.796     Document Type: Article

References (26)

1. Young RC, Ozols RF, Myers CE. The anthracycline antineoplastic drugs. N. Engl. J. Med., 305, 139-153 (1981).
2. Weiss RB. The anthracyclines: will we ever find a better doxorubicin? Semin. Oncol., 19, 670-686 (1992).
3. Silber JH, Barber G. Doxorubicin-induced cardiotoxicity. N. Engl. J. Med., 333, 1359-1360 (1995).
4. Yeh ETH, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation, 109, 3122-3131 (2004).
5. Kalender Y, Yel M, Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209, 39-45 (2005).
6. Bárdi E, Bobok I, Oláh AV, Kappelmayer J, Kiss C. Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer. Pathol. Oncol. Res., 13, 249-253 (2007).
7. Yang XL, Fan CH, Zhu HS. Photo-induced cytotoxicity of malonic acid [C(60)]fullerene derivatives and its mechanism. Toxicol. In Vitro, 16, 41-46 (2002).
8. Kassner N, Huse K, Martin HJ, Gödtel-Armbrust U, Metzger A, Meineke I, Brockmöller J, Klein K, Zanger UM, Maser E, Wojnowski L. Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab. Dispos., 36, 2113-2120 (2008).
9. Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Khai NC, Maruyama R, Ogino A, Minatoguchi S, Fujiwara T, Fujiwara H. Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. Circulation, 113, 535-543 (2006).
10. Yeh YC, Lai HC, Ting CT, Lee WL, Wang LC, Wang KY, Lai HC, Liu TJ. Protection by doxycycline against doxorubicin-induced oxidative stress and apoptosis in mouse testes. Biochem. Pharmacol., 74, 969-980 (2007).
11. Onoda T, Ono T, Dhar DK, Yamanoi A, Nagasue N. Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and -independent apoptosis in human colon cancer cells. Int. J. Cancer, 118, 1309-1315 (2006).
12. Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Am. J. Physiol. Endocrinol. Metab., 294, E148-E156 (2008).
13. Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr. Vasc. Pharmacol., 7, 330-337 (2009).
14. Ko YJ, Lee JS, Park BC, Shin HM, Kim JA. Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. Vascul. Pharmacol., 47, 189-196 (2007).
15. Cho BJ, Im EK, Kwon JH, Lee KH, Shin HJ, Oh J, Kang SM, Chung JH, Jang Y. Berberine inhibits the production of lysophosphatidylcholine- induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. Mol. Cells, 20, 429-434 (2005).
16. Kalender Y, Yel M, Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209, 39-45 (2005).
17. Mimnaugh EG, Trush MA, Ginsburg E, Gram TE. Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation. Cancer Res., 42, 3574-3582 (1982).
18. Pradeep K, Mohan CV, Gobianand K, Karthikeyan S. Effect of Cassia fistula LINN. leaf extract on diethylnitrosamine induced hepatic injury in rats. Chem. Biol. Interact., 167, 12-18 (2007).
19. Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B. Doxorubicin- induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J. Biol. Chem., 275, 33585-33592 (2000).
20. Kalender Y, Yel M, Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209, 39-45 (2005).
21. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J. Clin. Endocrinol. Metab., 93, 2559-2565 (2008).
22. Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J, Wang Y, Li Z, Liu J, Jiang JD. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med., 10, 1344-1351 (2004).
23. Patil JB, Kim J, Jayaprakasha GK. Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. Eur. J. Pharmacol., 645, 70-78 (2010).
24. Kim JB, Yu JH, Ko E, Lee KW, Song AK, Park SY, Shin I, Han W, Noh DY. The alkaloid berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. Phytomedicine, 17, 436-440 (2010).
25. Kim S, Choi JH, Kim JB, Nam SJ, Yang JH, Kim JH, Lee JE. Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules, 13, 2975-2985 (2008).
26. Zhao XY, Zhang J, Tong NN, Liao XG, Wang EB, Li ZB, Luo YH, Zuo H. Berberine attenuates doxorubicin-induced cardiotoxicity in mice. J. Int. Med. Res., 39, 1720-1727 (2011).