Frozen section pathology at time of hysterectomy accurately predicts endometrial cancer in patients with preoperative diagnosis of atypical endometrial hyperplasia

Gynecologic Oncology

Volumn 125, Issue 3, 2012, Pages 536-540

  Morotti, Matteo ^a   Menada, Mario Valenzano ^a   Moioli, Melita ^a,b   Sala, Paolo ^a   Maffeo, Ilaria ^a   Abete, Luca ^a   Fulcheri, Ezio ^a   Menoni, Stefania ^a   Venturini, Pierluigi ^a   Papadia, Andrea ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Atypical endometrial hyperplasia; Endometrial cancer; Frozen section

Indexed keywords

ADULT; AGED; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER INVASION; CANCER RISK; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; ENDOMETRIUM BIOPSY; ENDOMETRIUM CANCER; ENDOMETRIUM HYPERPLASIA; FEMALE; FROZEN SECTION; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MYOMETRIUM; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TUMOR DIFFERENTIATION;

ADULT; AGED; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; FEMALE; FROZEN SECTIONS; HUMANS; HYSTERECTOMY; MIDDLE AGED; MONITORING, INTRAOPERATIVE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES;

EID: 84861202787     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.02.011     Document Type: Conference Paper

References (35)

1. R.E. Scully, T.A. Bonfiglio, R.J. Kurman, S.G. Silverberg, and J. Wilkinson Uterine corpus R.E. Scully, H.E. Poulsen, L.H. Sobin, Histological typing of female genital tract tumors 1994 Springer-Verlag New York 13
2. R. Kurman, P. Kaminski, and H. Norris The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients Cancer 56 1985 403 411
3. C.L. Trimble, J. Kauderer, and R. Zaino Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study Cancer 106 2006 812 819
4. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. American College of Obstetricians and Gynecologists Obstet Gynecol 106 2005 413 425
5. ASTEC study group H. Kitchener, A.M. Swart, Q. Qian, C. Amos, and M.K. Parmar Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study Lancet 373 2009 125 136
6. P. Benedetti Panici, S. Basile, F. Maneschi, A.A. Lissoni, M. Signorelli, and G. Scambia Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial J Natl Cancer Inst 100 2008 1707 1716
7. W.T. Creasman, C.P. Morrow, B.N. Bundy, H.D. Homesley, J.E. Graham, and P.B. Heller Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group study Cancer 60 1987 2035 2041
8. R.R. Barakat, G. Lev, A.J. Hummer, Y. Sonoda, D.S. Chi, and K.M. Alektiar Twelve-year experience in the management of enodometrial cancer: a change in surgical and postoperative radiation approaches Gynecol Oncol 105 2007 150 156
9. S. Pecorelli, J.L. Benedet, W.T. Creasman, and J.H. Shepherd FIGO staging of gynecologic cancer. 1994-1997 FIGO Committee on Gynecologic Oncology. International Federation of Gynecology and Obstetrics Int J Gynaecol Obstet 65 1999 243 249
10. T. Bilgin, S. Ozuysal, H. Ozan, and T. Atakan Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia J Obstet Gynaecol Res 30 2004 205 209
11. M.F. Janicek, and N.B. Rosenshein Invasive endometrial carcinoma in uteri resected for atypical endometrial hyperplasia Gynecol Oncol 52 1994 373 378
12. T. Kimura, S. Kamiura, T. Komoto, H. Seino, K. Tenma, and Y. Ohta Clinical over- and under-estimation in patients who underwent hysterectomy for atypical endometrial hyperplasia diagnosed by endometrial biopsy: the predictive value of clinical parameters and diagnostic imaging Eur J Obstet Gynecol Reprod Biol 108 2003 213 216
13. J. Kovacic, and S. Rainer Atypical hyperplasia and endometrial carcinoma Jugosl Ginekol Opstet 18 1978 201 206
14. R.J. Kurman, and H.J. Norris Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma Cancer 49 1982 2547 2559
15. C. Merisio, R. Berretta, A. De Ioris, D.C. Pultrone, M. Rolla, and G. Giordano Endometrial cancer in patients with preoperative diagnosis of atypical endometrial hyperplasia Eur J Obstet Gynecol Reprod Biol 112 2005 107 111
16. J. Shutter, and T.C. Wright Jr. Prevalence of underlying adenocarcinoma in women with atypical endometrial hyperplasia Int J Gynecol Pathol 24 2005 313 318
17. F. Tavassoli, and F.T. Kraus Endometrial lesions in uteri resected for atypical endometrial hyperplasia Am J Clin Pathol 70 1978 770 779
18. P. Valenzuela, J.M. Sanz, and J. Keller Atypical endometrial hyperplasia: grounds for possible misdiagnosis of endometrial adenocarcinoma Gynecol Obstet Invest 56 2003 163 167
19. K.C. Ventura, D. Popiolek, and K. Mittal Endometrial adenocarcinoma in situ in complex atypical hyperplasia: correlation with findings in subsequent hysterectomy specimen Int J Surg Pathol 12 2004 225 230
20. S. Pennant, S. Manek, and S. Kehoe Endometrial atypical hyperplasia and subsequent diagnosis of endometrial cancer: a retrospective audit and literature review J Obstet Gynaecol 28 2008 632 633
21. C. Bergeron, F.F. Nogales, M. Masseroli, V. Abeler, P. Duvillard, and E. Müller-Holzner A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens Am J Surg Pathol 23 1999 1102 1108
22. R.J. Zaino, J. Kauderer, C.L. Trimble, S.G. Silverberg, J.P. Curtin, and P.C. Lim Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study Cancer 106 2006 804 811
23. G.L. Mutter, J.P. Baak, C.P. Crum, R.M. Richart, A. Ferenczy, and W.C. Faquin Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry J Pathol 190 2000 462 469
24. M.M. Leitao Jr., G. Han, L.X. Lee, N.R. Abu-Rustum, C.L. Brown, and D.S. Chi Complex atypical hyperplasia of the uterus: characteristics and prediction of underlying carcinoma risk Am J Obstet Gynecol 203 2010 e1 e6
25. K. Ushijima, H. Yahata, H. Yoshikawa, I. Konishi, T. Yasugi, and T. Saito Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women J Clin Oncol 25 2007 2798 2803
26. W.H. Parker, M.S. Broder, and Z. Liu Ovarian conservation at the time of hysterectomy for benign disease Obstet Gynecol 106 2005 219 226
27. W.H. Parker, M.S. Broder, Z. Liu, D. Shoupe, and C. Farquhar Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study Obstet Gynecol 113 2009 1027 1037
28. M. Franchi, F. Ghezzi, C. Riva, M. Miglierina, M. Buttarelli, and P. Bolis Postoperative complications after pelvic lymphadenectomy for the surgical staging of endometrial cancer J Surg Oncol 78 2001 232 240
29. N.R. Abu-Rustum, K. Alektiar, A. Iasonos, G. Lev, and Y. Sonoda The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: a 12-year experience at Memorial Sloan-Kettering Cancer Center Gynecol Oncol 103 2006 714 718
30. A. Papadia, G. Azioni, B. Brusacà, E. Fulcheri, K. Nishida, and S. Menoni Frozen section underestimates the need for surgical staging in endometrial cancer patients Int J Gynecol Cancer 19 2009 1570 1573
31. S.L. Antonsen, L. Ulrich, and C. Hogdall Patients with atypical hyperplasia of the endometrium should be treated in oncological centers Gynecol Oncol 2011 [e-pub ahead of print] PMID: 22198048
32. T. Bilgin, S. Ozuysal, H. Ozan, and T. Atakan Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia J Obstet Gynaecol Res 3 2004 205 209
33. M.D. Indermaur, B. Shoup, S. Tebes, and J.M. Lancaster The accuracy of frozen pathology at time of hysterectomy in patients with complex atypical hyperplasia on preoperative diagnosis Am J Obstet Gynecol 196 2007 e40 e42
34. M.C. Salman, A. Usubutun, N.U. Dogan, and K. Yuce The accuracy of frozen section at hysterectomy in patients with atypical endometrial hyperplasia Clin Exp Obstet Gynecol 36 2009 31 34
35. S. Attard Montalto, M. Coutts, O. Devaja, J. Summers, R. Jyothirmayi, and A. Papadopoulos Accuracy of frozen section diagnosis in pre-malignant and malignant lesions of the endometrium Eur J Gynaecol Oncol 29 2008 435 440