IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease

Journal of Hepatology

Volumn 56, Issue 6, 2012, Pages 1356-1362

  Petta, Salvatore ^a   Grimaudo, Stefania ^a   Cammà, Calogero ^a   Cabibi, Daniela ^a   Marco, Vito Di ^a   Licata, Giusalba ^a   Pipitone, Rosaria Maria ^a   Craxì, Antonio ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

IL28B; NASH

Indexed keywords

INTERLEUKIN 28B; PATATIN LIKE PHOSPHOLIPASE 3; PHOSPHOLIPASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERURICEMIA; LIVER BIOPSY; LIVER FIBROSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HUMANS; INTERLEUKINS; LIPASE; LIVER; LOGISTIC MODELS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84861201337     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.01.007     Document Type: Article

References (39)

1. S. Petta, C. Muratore, and A. Craxì Non-alcoholic fatty liver disease pathogenesis: the present and the future Dig Liver Dis 41 2009 615 625
2. G. Marchesini, E. Bugianesi, and G. Forlani Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome Hepatology 37 2003 917 923 (Pubitemid 36397405)
3. G. Bedogni, L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, and S. Bellentani Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study Hepatology 42 2005 44 52 (Pubitemid 40911310)
4. S. Petta, and A. Craxì Hepatocellular carcinoma and non-alcoholic fatty liver disease: from a clinical to a molecular association Curr Pharm Des 16 2010 741 752
5. Petta S, Tripodo C, Grimaudo S, et al. High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis. Dig Liver Dis 2011 Feb 14. [Epub ahead of print] PubMed PMID: 21324757.
6. D. van der Poorten, K.L. Milner, and J. Hui Visceral fat: a key mediator of steatohepatitis in metabolic liver disease Hepatology 48 2008 449 457
7. E. Bugianesi, G. Marchesini, and E. Gentilcore Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis Hepatology 44 2006 1648 1655 (Pubitemid 44953669)
8. C.K. Argo, P.G. Northup, and A.M. Al-Osaimi Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis J Hepatol 51 2009 371 379
9. H. Tilg, and A. Moschen Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation Curr Opin Clin Nutr Metab Care 13 2010 391 396
10. S. Sookoian, G.O. Castano, A.L. Burgueno, G.T. Fernandez, M.S. Rosselli, and C.J. Pirola A nonsynonymous gene variant in adiponutrin gene is associated with nonalcoholic fatty liver disease severity J Lipid Res 50 2009 2111 2116
11. Y. Rotman, C. Koh, J.M. Zmuda, D.E. Kleiner, and T.J. Liang The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease Hepatology 52 2010 894 903
12. E.K. Speliotes, J.L. Butler, C.D. Palmer, B.F. Voight, and J.N. Hirschhorn PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease Hepatology 52 2010 904 912
13. L. Valenti, A. Al-Serri, A.K. Daly, E. Galmozzi, R. Rametta, and P. Dongiovanni Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease Hepatology 51 2010 1209 1217
14. S. Sookoian, and C.J. Pirola Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease Hepatology 53 2011 1883 1894
15. D. Ge, J. Fellay, and A.J. Thompson Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
16. V. Suppiah, M. Moldovan, and G. Ahlenstiel IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy Nat Genet 41 2009 1100 1104
17. Y. Tanaka, N. Nishida, and M. Sugiyama Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Nat Genet 41 2009 1105 1109
18. A. Rauch, Z. Kutalik, and P. Descombes Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study Gastroenterology 138 2010 1338 1345
19. A.J. Thompson, A.J. Muir, and M.S. Sulkowski Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus Gastroenterology 139 2010 120 129
20. Tillmann HL, Patel K, Muir AJ, Guy CD, Li JH, Lao XQ, et al. Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. J Hepatol 2011 Apr 14. [Epub ahead of print] PubMed PMID: 21703198.
21. Cai T, Dufour JF, Muellhaupt B, Gerlach T, Heim M, Moradpour D, et al. On behalf of the Swiss Hepatitis C Cohort Study Group. Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. J Hepatol 2011 Jan 12. [Epub ahead of print] PubMed PMID: 21236304.
22. H. Abe, H. Ochi, T. Maekawa, C.N. Hayes, M. Tsuge, and D. Miki Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients J Hepatol 53 2010 439 443
23. A.J. Thompson, P.J. Clark, M. Zhu, Q. Zhu, D. Ge, and M.S. Sulkowski Genome wide-association study identifies IL28B polymorphism to be associated with baseline alt and hepatic necroinflammatory activity in chronic hepatitis C patients enrolled in the IDEAL study Hepatology 52 2010 1220
24. Marabita F, Aghemo A, De Nicola S, Rumi MG, Cheroni C, Scavelli R, et al. Genetic variation in IL28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection. Hepatology. 2011 Jun 30. doi:10.1002/hep.24503. [Epub ahead of print] PubMed PMID: 21721028.
25. Falleti E, Bitetto D, Fabris C, Cussigh A, Fornasiere E, Cmet S, et al. Role of Interleukin 28B rs12979860 C/T Polymorphism on the Histological Outcome of Chronic Hepatitis C: Relationship with Gender and Viral Genotype. J Clin Immunol 2011 Jun 7. [Epub ahead of print] PubMed PMID: 21647799.
26. A.J. Thompson, P.J. Clark, J. Fellay, A.J. Muir, H.L. Tillmann, and K. Patel IL28B genotype is not associated with advanced hepatic fibrosis in chronic hepatitis C patients enrolled in the ideal study Hepatology 52 2010 437A
27. American Diabetes Association Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. American Diabetes Association: clinical practice recommendations 2000 committee report Diabetes Care 23 2000 S4 S19
28. D.R. Matthews, J.P. Hosker, and A.S. Rudenski Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
29. Y. Ikeda, T. Suehiro, and T. Nakamura Clinical significance of the insulin resistance index as assessed by homeostasis model assessment Endocr J 48 2001 81 86 (Pubitemid 32230388)
30. J. Fang, and M.H. Alderman Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey JAMA 283 2000 2404 2410 (Pubitemid 30257539)
31. G. Colloredo, M. Guido, A. Sonzogni, and G. Leandro Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease J Hepatol 39 2003 239 244 (Pubitemid 36920560)
32. D.E. Kleiner, E.M. Brunt, and M. Van Natta Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 411 2005 313 321
33. SAS Technical Report, SAS/STAT software: changes and enhancement, Release 6.07. Cary, NC: SAS Institute, Inc.; 1992.
34. J.B. Schwimmer, M.A. Celedon, J.E. Lavine, R. Salem, N. Campbell, and N.J. Schork Heritability of nonalcoholic fatty liver disease Gastroenterology 136 2009 1585 1592
35. Petta S, Ferraro D, Cammà C, Cabibi D, Di Cristina A, Di Marco V, et al. Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C. Antiviral Ther, in press.
36. Di Marco V, Bronte F, Calvaruso V, Capra M, Borsellino Z, Maggio A, et al. IL28B polymorphisms influence stage of the liver fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection. Haematologica 2011 Dec 16. [Epub ahead of print] PMID: 22180419.
37. M. Honda, A. Sakai, T. Yamashita, Y. Nakamoto, E. Mizukoshi, and Y. Sakai Hokuriku Liver Study Group. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C Gastroenterology 139 2010 499 509
38. S. Petta, C. Cammà, D. Cabibi, V. Di Marco, and A. Craxì Hyperuricemia is associated with histological liver damage in patients with nonalcoholic fatty liver disease APT 34 2011 757 766
39. E.M. Brunt, D.E. Kleiner, L.A. Wilson, and P. Belt NASH Clinical Research Network (CRN). Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings Hepatology 53 2011 810 820