Non-invasive diagnosis of hepatocellular carcinoma ≤2 cm in cirrhosis. Diagnostic accuracy assessing fat, capsule and signal intensity at dynamic MRI

Journal of Hepatology

Volumn 56, Issue 6, 2012, Pages 1317-1323

  Rimola, Jordi ^a,b   Forner, Alejandro ^a,b   Tremosini, Silvia ^a   Reig, Maria ^a,b   Vilana, Ramón ^a,b   Bianchi, Luis ^a,b   Rodríguez Lope, Carlos ^a   Solé, Manel ^a,b   Ayuso, Carmen ^a,b   Bruix, Jordi ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Cirrhosis; Diagnosis; Dynamic imaging; Hepatocellular carcinoma; Magnetic resonance

Indexed keywords

GADODIAMIDE; SONOVUE;

ADULT; AGED; ARTICLE; BENIGN TUMOR; BILE DUCT CARCINOMA; CANCER DIAGNOSIS; CANCER SCREENING; CANCER SIZE; CONTRAST ENHANCEMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ECHOGRAPHY; FALSE POSITIVE RESULT; FATTY LIVER; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HEMANGIOMA; LIVER METASTASIS; LIVER NODULE; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIODIAGNOSIS; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84861198235     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.01.004     Document Type: Article

References (26)

1. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
2. A. Sangiovanni, G.M. Prati, P. Fasani, G. Ronchi, R. Romeo, and M. Manini The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients Hepatology 43 2006 1303 1310 (Pubitemid 43980109)
3. J. Bruix, and M. Sherman Management of hepatocellular carcinoma: an update Hepatology 53 2011 1020 1022
4. P. Ferenci, M. Fried, D. Labrecque, J. Bruix, M. Sherman, and M. Omata Hepatocellular carcinoma (HCC): a global perspective J Clin Gastroenterol 44 2010 239 245
5. S. Jelic Hepatocellular carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up Ann Oncol 20 Suppl. 4 2009 41 45
6. A. Forner, C. Ayuso, M. Isabel Real, J. Sastre, R. Robles, and B. Sangro Diagnosis and treatment of hepatocellular carcinoma Med Clin (Barc) 132 2009 272 287
7. International Consensus Group for Hepatocellular Neoplasia The International Consensus Group for Hepatocellular Neoplasia consists of: Masamichi Kojiro IRW, Venancio Alves, Sunil Badve, Charles Balabaud, Pierre Bedosa, Prithi Bhathal, Paulette Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia Hepatology 49 2008 658 664
8. M. Burrel, J.M. Llovet, C. Ayuso, C. Iglesias, M. Sala, and R. Miquel MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation Hepatology 38 2003 1034 1042 (Pubitemid 37221687)
9. R. Lencioni, D. Cioni, C. Della Pina, L. Crocetti, and C. Bartolozzi Imaging diagnosis Semin Liver Dis 25 2005 162 170 (Pubitemid 40781069)
10. J.M. Llovet, A.M. Di Bisceglie, J. Bruix, B.S. Kramer, R. Lencioni, and A.X. Zhu Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 2008 698 711
11. A. Forner, R. Vilana, C. Ayuso, L. Bianchi, M. Solé, and J.R. Ayuso Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma Hepatology 47 2008 97 104 (Pubitemid 351171046)
12. S. Leoni, F. Piscaglia, R. Golfieri, V. Camaggi, G. Vidili, and P. Pini The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria Am J Gastroenterol 105 2010 599 609
13. K.T. Khalili, T.K. Kim, H.J. Jang, M.A. Haider, L. Khan, and M. Guindi Optimization of imaging diagnosis of 1-2 cm hepatocellular carcinoma: an analysis of diagnostic performance and resource utilization J Hepatol 54 2011 723 728
14. A. Sangiovanni, M.A. Manini, M. Iavarone, R. Romeo, L.V. Forzenigo, and M. Fraquelli The diagnostic and economic impact of contrast imaging technique in the diagnosis of small hepatocellular carcinoma in cirrhosis Gut 59 2010 638 644
15. L. Grazioli, L. Olivetti, C. Fugazzola, A. Benetti, C. Stanga, and E. Dettori The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology Eur Radiol 9 1999 62 67
16. Forner A, Llovet J, Bruix J. Hepatocellular carcinoma. Lancet 2012. doi:10.1016/S0140-6736(11)61347-0 [Epub ahead of print].
17. J.M. Willatt, H.K. Hussain, S. Adusumilli, and J.A. Marrero MR imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies Radiology 247 2008 311 330
18. G.A. Krinsky, and V.S. Lee MR imaging of cirrhotic nodules Abdom Imaging 25 2000 471 482 (Pubitemid 30659299)
19. A.S. Khan, H.K. Hussain, T.D. Johnson, W.J. Weadock, S.J. Pelletier, and J.A. Marrero Value of delayed hypointensity and delayed enhancing rim in magnetic resonance imaging diagnosis of small hepatocellular carcinoma in the cirrhotic liver J Magn Reson Imaging 32 2010 360 366
20. T.K. Kim, K.H. Lee, H.J. Jang, M.A. Haider, L.M. Jacks, and R.J. Menezes Analysis of gadobenate dimeglumine-enhanced MR findings for characterizing small (1-2-cm) hepatic nodules in patients at high risk for hepatocellular carcinoma Radiology 259 2011 730 738
21. K. Okuda, T. Nakashima, H. Obata, and Y. Kubo Clinicopathological studies of minute hepatocellular carcinoma. Analysis of 20 cases, including 4 with hepatic resection Gastroenterology 73 1977 109 115 (Pubitemid 8143349)
22. A. Eguchi, O. Nakashima, S. Okudaira, S. Sugihara, and M. Kojiro Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma Hepatology 15 1992 843 848
23. J. Martin, M. Sentis, A. Zidan, L. Donoso, J. Puig, and J. Falco Fatty metamorphosis of hepatocellular carcinoma: detection with chemical shift gradient-echo MR imaging Radiology 195 1995 125 130
24. J.S. Yu, J.J. Chung, J.H. Kim, and K.W. Kim Fat-containing nodules in the cirrhotic liver: chemical shift MRI features and clinical implications AJR Am J Roentgenol 188 2007 1009 1016 (Pubitemid 46496933)
25. V. Vandecaveye, F. De Keyzer, C. Verslype, K. Op de Beeck, M. Komuta, and B. Topal Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma Eur Radiol 19 2009 2456 2466
26. H.Y. Sun, J.M. Lee, C.I. Shin, D.H. Lee, S.K. Moon, and K.W. Kim Gadoxetic acid-enhanced magnetic resonance imaging for differentiating small hepatocellular carcinomas (< or = 2cm in diameter) from arterial enhancing pseudolesions: special emphasis on hepatobiliary phase imaging Invest Radiol 45 2010 96 103