Association between PLA2G6 gene polymorphisms and Parkinson's disease in the Chinese Han population

Parkinsonism and Related Disorders

Volumn 18, Issue 5, 2012, Pages 641-644

  Lv, Zhanyun ^a   Guo, Jifeng ^a   Sun, Qiying ^a   Li, Kai ^a   Yu, Rili ^a   Tian, Jinyong ^a   Yan, Xinxiang ^a   Tang, Beisha ^a,b,c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c The First People s Hospital of Changde City)   (China)

Author keywords

Parkinson's disease; PLA2G6; Rs132985; Rs2267369; Rs2284063; Rs4375; Single nucleotide polymorphisms

Indexed keywords

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENE; GENE AMPLIFICATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MUTATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PLA2G6 GENE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GROUP VI PHOSPHOLIPASES A2; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84861194147     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2012.02.015     Document Type: Article

References (12)

1. Rocca W.A. Prevalence of Parkinson's disease in China. Lancet Neurol 2005, 4:328-329.
2. Paisan-Ruiz C., Bhatia K.P., Li A., Hernandez D., Davis M., Wood N.W., et al. Characterization of PLA2G6 as a locus for dystonia-parkinsonism. Ann Neurol 2009, 65:19-23.
3. McNeill A., Chinnery P.F. Neurodegeneration with brain iron accumulation. Handb Clin Neurol 2011, 100:161-172.
4. Rosa A.O., Rapoport S.I. Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids. Biochim Biophys Acta 2009, 1791:697-705.
5. Paisan-Ruiz C., Li A., Schneider S.A., Holton J.L., Johnson R., Kidd D., et al. Widespread lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging 2010, published online 9 July 2010. 10.1016/j.neurobiolaging.2010.05.009.
6. Shi C.H., Tang B.S., Wang L., Lv Z.Y., Wang J., Luo L.Z., et al. PLA2G6 gene mutation in autosomal recessive early-onset parkinsonism in a Chinese cohort. Neurology 2011, 77:75-81.
7. Kauther K.M., Hoft C., Rissling I., Oertel W.H., Moller J.C. The PLA2G6 gene in early-onset Parkinson's disease. Mov Disord 2011, 26:2415-2417.
8. Yoshino H., Tomiyama H., Tachibana N., Ogaki K., Li Y., Funayama M., et al. Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism. Neurology 2010, 75:1356-1361.
9. Bishop D.T., Demenais F., Iles M.M., Harland M., Taylor J.C., Corda E., et al. Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet 2009, 41(8):920-925.
10. Falchi M., Bataille V., Hayward N.K., Duffy D.L., Bishop J.A., Pastinen T., et al. Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi. Nat Genet 2009, 41:915-919.
11. Liu R., Gao X., Lu Y., Chen H. Meta-analysis of the relationship between Parkinson disease and melanoma. Neurology 2011, 76:2002-2009.
12. Kvaskoff M., Whiteman D.C., Zhao Z.Z., Montgomery G.W., Martin N.G., Hayward N.K., et al. Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma. Twin Res Hum Genet 2011, 14:422-432.