Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor

Biotechnology and Bioengineering

Volumn 109, Issue 7, 2012, Pages 1844-1854

  Youssef, K ^a   Mack, J J ^a   Iruela Arispe, M L ^a   Bouchard, L S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Flow mapping; Flow simulation; Porous scaffold; Topology optimization

Indexed keywords

CELL FUNCTIONS; CELL TYPES; CHANNEL TOPOLOGY; COMPUTATIONAL FLUID DYNAMICS SIMULATIONS; EX-VIVO; FLOW CONDITION; FLOW DISTRIBUTION; FLOW MAPPING; GROWTH FACTOR; MACRO SCALE; MICROSTRUCTURAL PARAMETERS; OPTIMIZATION ALGORITHMS; PHYSICAL FACTORS; POROUS SCAFFOLD; TARGET VALUES;

ALGORITHMS; BIOCONVERSION; BIOREACTORS; BLOOD VESSELS; CELL CULTURE; COMPUTATIONAL FLUID DYNAMICS; FLOW SIMULATION; FUZZY LOGIC; MAGNETIC RESONANCE IMAGING; OPTIMIZATION; SHAPE OPTIMIZATION; SHEAR STRESS;

SCAFFOLDS (BIOLOGY);

MOLECULAR SCAFFOLD;

ARTICLE; BIOREACTOR; COMPUTATIONAL FLUID DYNAMICS; FLOW MEASUREMENT; FLOW RATE; FUZZY LOGIC; GENETIC ALGORITHM; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCESS OPTIMIZATION; SHEAR STRESS; VALIDATION PROCESS;

ALGORITHMS; BIOREACTORS; COMPUTER SIMULATION; FUZZY LOGIC; HYDRODYNAMICS; MODELS, CHEMICAL; POROSITY; SHEAR STRENGTH; STRESS, MECHANICAL; TISSUE SCAFFOLDS;

EID: 84861188537     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24440     Document Type: Article

References (23)

1. Bancroft GN, Sikavitsas VI, Mikos AG. 2003. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng 9: 549-554.
2. Brown MA, Iyer RK, Radisic M. 2008. Pulsatile perfusion bioreactor for cardiac tissue engineering. Biotechnol Prog 24: 907-920.
3. Callaghan PT. 1994. Principles of nuclear magnetic resonance microscopy. New York: Oxford University Press.
4. Choi NW, Cabodi M, Held B, Gleghorn JP, Bonassar LJ, Stroock AD. 2007. Microfluidic scaffolds for tissue engineering. Nat Mater 6: 908-915.
5. Datta N, Pham QP, Sharma U, Sikavitsas VI, Jansen JA, Mikos AG. 2006. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblatic differentiation. PNAS 103: 2488-2493.
6. Dermenoudis S, Missirlis YF. 2010. Bioreactors in tissue engineering. Adv Mater 12: B592-B608.
7. Hillsley MV, Frangos JA. 1997. Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow. Calcif Tissue Int 60: 48-53.
8. Jiang GL, White CR, Stevens HY, Frangos JA. 2002. Temporal gradients in shear stimulate osteoblastic proliferation via ERK 1/2 and retinoblastoma protein. Am J Physiol Endocrinol Metab 283: E383-E389.
9. Khoda AFMB, Ozbolat IT, Koc B. 2011. Engineered tissue scaffolds with variational porous architecture. J Biomech Eng 133: 011001.
10. Klein-Nulend J, Helfrich MH, Sterck JG, MacPherson H, Joldersma M, Ralston SH, Semeins CM, Burger EH. 1998. Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent. Biochem Biophys Res Commun 250: 108-114.
11. McAllister TN, Du T, Frangos JA. 2000. Fluid shear stress stimulates prostaglandin and nitric oxide release in bone marrow derived preosteoclast-like cells. Biochem Biophys Res Commun 270: 643-648.
12. Nollert MU, Diamond SL, McIntire LV. 1991. Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Biotechnol Bioeng 38: 588.
13. Okkels F, Dufva M, Bruus H. 2011. Optimal homogenization of perfusion flows in microfluidic bio-reactors: A Numerical Study. PLoS ONE 6: e14574-e14574.
14. Porter B, Zauel R, Stockman H, Guldberg R, Fyhrie D. 2005. 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J Biomech 38: 543.
15. Reich KM, Frangos JA. 1991. Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts. Am J Physiol 261: C428-C432.
16. Sivanandam SN, Sumathi S, Deepa SN. 2007. Introduction to Fuzzy Logic Using MATLAB. Berlin: Springer-Verlag.
17. Smalt R, Mitchell FT, Howard RL, Chambers TJ. 1997. Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain. Am J Physiol 273: E751-E758.
18. Stolberg S, McCloskey KE. 2009. Can shear stress direct stem cell fate? Biotechnol Prog 25: 10-19.
19. Succi S. 2001. The Lattice Boltzmann equation for fluid dynamics and beyond: Numerical mathematics and scientific computation. New York: Oxford University Press.
20. Torquato S. 2001. Random heterogeneous materials: Microstructure and macroscopic properties. New York: Springer-Verlag.
21. VanGordon SB, Voronov RS, Blue TB, Shambaugh RL, Papavassiliou DV, Sikavitsas VI. 2011. Effects of scaffold architecture on preosteoblastic cultures under continuous fluid shear. Ind Eng Chem Res 50: 620-629.
22. Voronov RS, VanGordon SB, Sikavitsas VI, Papavassiliou DV. 2010a. Distribution of flow-induced stresses in highly porous media. Appl Phys Lett 97: 024101.
23. Voronov RS, VanGordona SB, Sikavitsasa VI, Papavassiliou DV. 2010b. Computational modeling of flow-induced shear stresses within 3D salt-leached porous scaffolds imaged via micro-CT. J Biomech 43: 1279-1286.