Two weeks of muscle immobilization impairs functional sympatholysis but increases exercise hyperemia and the vasodilatory responsiveness to infused ATP

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 10, 2012, Pages

  Mortensen, S P ^a   Morkeberg J ^a   Thaning, P ^a   Hellsten, Y ^b   Saltin, B ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Adenosine; Adenosine 5 triphosphate; Blood flow; Sympathetic nerve activity

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; CATECHOLAMINE; PURINERGIC P2Y2 RECEPTOR; TYRAMINE;

ADRENERGIC ACTIVITY; ADULT; ARTICLE; BLOOD GAS ANALYSIS; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; EXERCISE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPEREMIA; IMMOBILIZATION; LEG BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MUSCLE CONTRACTION; MUSCLE TRAINING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REST; SKELETAL MUSCLE; SYMPATHETIC FUNCTION; VASODILATATION;

ADENOSINE; ADENOSINE TRIPHOSPHATE; EXERCISE; HUMANS; HYPEREMIA; INFUSIONS, INTRA-ARTERIAL; LEG; MALE; MUSCLE, SKELETAL; RECEPTORS, PURINERGIC P2Y2; REGIONAL BLOOD FLOW; RESTRAINT, PHYSICAL; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS; TYRAMINE; VASOCONSTRICTION; VASODILATION; YOUNG ADULT;

EID: 84861173125     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01204.2011     Document Type: Article

References (51)

1. Alam M, Smirk FH. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89: 372-383, 1937.
2. Amann M, Runnels S, Morgan DE, Trinity JD, Fjeldstad AS, Wray DW, Reese VR, Richardson RS. On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans. J Physiol 589: 3855-3866, 2011.
3. Bevegard BS, Shepherd JT. Reaction in man of resistance and capacity vessels in forearm and hand to leg exercise. J Appl Physiol 21: 123-132, 1966.
4. Borno A, Ploug T, Bune LT, Rosenmeier JB, Thaning P. Purinergic receptors expressed in human skeletal muscle fibres. Purinergic Signal In press.
5. Callister R, Ng AV, Seals DR. Arm muscle sympathetic nerve activity during preparation for and initiation of leg-cycling exercise in humans. J Appl Physiol 77: 1403-1410, 1994.
6. Clifford PS, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393-403, 2004.
7. Ellsworth ML, Forrester T, Ellis CG, Dietrich HH. The erythrocyte as a regulator of vascular tone. Am J Physiol Heart Circ Physiol 269: H2155-H2161, 1995.
8. González-Alonso J, Olsen DB, Saltin B. Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP. Circ Res 91: 1046-1055, 2002.
9. Hansen J, Thomas GD, Harris SA, Parsons WJ, Victor RG. Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle. J Clin Invest 98: 584-596, 1996.
10. Hansen J, Thomas GD, Jacobsen TN, Victor RG. Muscle metaboreflex triggers parallel sympathetic activation in exercising and resting human skeletal muscle. Am J Physiol Heart Circ Physiol 266: H2508-H2514, 1994.
11. Hollander AP, Bouman LN. Cardiac acceleration in man elicited by a muscle-heart reflex. J Appl Physiol 38: 272-278, 1975.
12. Kalliokoski KK, Oikonen V, Takala TO, Sipilä H, Knuuti J, Nuutila P. Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men. Am J Physiol Endocrinol Metab 280: E1015-E1021, 2001.
13. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol 469: 459-478, 1993.
14. Kiens B, Lithell H. Lipoprotein metabolism influenced by traininginduced changes in human skeletal muscle. J Clin Invest 83: 558-564, 1989.
15. Kirby BS, Voyles WF, Carlson RE, Dinenno FA. Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle. J Physiol 586: 4305-4316, 2008.
16. Kirby BS, Crecelius AR, Voyles WF, Dinenno FA. Modulation of postjunctional +{pipe}-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans. J Physiol 589: 2641-2653, 2011.
17. Klausen K, Secher NH, Clausen JP, Hartling O, Trap-Jensen J. Central and regional circulatory adaptations to one-leg training. J Appl Physiol 52: 976-983, 1982.
18. Koch DW, Leuenberger UA, Proctor DN. Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation. J Physiol 551: 337-344, 2003.
19. Krustrup P, Hellsten Y, Bangsbo J. Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities. J Physiol 559: 335-345, 2004.
20. Linke A, Schoene N, Gielen S, Hofer J, Erbs S, Schuler G, Hambrecht R. Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol 37: 392-397, 2001.
21. Marcus AJ, Broekman MJ, Drosopoulos JHF, Islam N, Pinsky DJ, Sesti C, Levi R. Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1). J Thromb Haemosta 1: 2497-2509, 2003.
22. Martin EA, Nicholson WT, Eisenach JH, Charkoudian N, Joyner MJ. Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia. J Appl Physiol 101: 492-499, 2006.
23. Mitchell JH, Kaufman MP, Iwamoto GA. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol 45: 229-242, 1983.
24. Mortensen SP, Gonzalez-Alonso J, Bune LT, Saltin B, Pilegaard H, Hellsten Y. ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine. Am J Physiol Regul Integr Comp Physiol 296: R1140-R1148, 2009.
25. Mortensen SP, Gonzalez-Alonso J, Nielsen JJ, Saltin B, Hellsten Y. Muscle interstitial ATP and norepinephrine concentrations in the human leg during exercise and ATP infusion. J Appl Physiol 107: 1757-1762, 2009.
26. Mortensen SP, Nyberg M, Thaning P, Saltin B, Hellsten Y. Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. Hypertension 53: 993-999, 2009.
27. Mortensen SP, Thaning P, Nyberg M, Saltin B, Hellsten Y. Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique. J Physiol 589: 1847-1857, 2011.
28. Mourtzakis M, Gonzalez-Alonso J, Graham TE, Saltin B. Hemodynamics and O2 uptake during maximal knee extensor exercise in untrained and trained human quadriceps muscle: effects of hyperoxia. J Appl Physiol 97: 1796-1802, 2004.
29. Nyberg M, Jensen LG, Thaning P, Hellsten Y, Mortensen SP. Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training. J Physiol In press.
30. Nyberg M, Mortensen SP, Thaning P, Saltin B, Hellsten Y. Interstitial and plasma adenosine stimulate nitric oxide and prostacyclin formation in human skeletal muscle. Hypertension 56: 1102-1108, 2010.
31. Padilla J, Simmons GH, Bender SB, Arce-Esquivel AA, Whyte JJ, Laughlin MH. Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiology 26: 132-145, 2011.
32. Proctor DN, Miller JD, Dietz NM, Minson CT, Joyner MJ. Reduced submaximal leg blood flow after high-intensity aerobic training. J Appl Physiol 91: 2619-2627, 2001.
33. Rådegran G, Calbet JA. Role of adenosine in exercise-induced human skeletal muscle vasodilatation. Acta Physiol Scand 171: 177-185, 2001.
34. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492, 1998.
35. Ray CA, Mark AL. Sympathetic nerve activity to nonactive muscle of the exercising and nonexercising limb. Med Sci Sports Exerc 27: 183-187, 1995.
36. Ray CA. Sympathetic adaptations to one-legged training. J Appl Physiol 86: 1583-1587, 1999.
37. Remensnyder J, Mitchell JH, Sarnoff SJ. Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptake. Circ Res 11: 370-380, 1962.
38. Rosenmeier JB, Hansen J, González-Alonso J. Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol 558: 351-365, 2004.
39. Rosenmeier JB, Yegutkin GG, Gonzalez-Alonso J. Activation of ATP/ UTP selective receptors increase blood flow and blunt sympathetic vasoconstriction in human skeletal muscle. J Physiol 586: 4993-5002, 2008.
40. Rowell LB. Human cardiovascular control. Ann Intern Med 119: 1234-123b, 1993.
41. Saito M, Tsukanaka A, Yanagihara D, Mano T. Muscle sympathetic nerve responses to graded leg cycling. J Appl Physiol 75: 663-667, 1993.
42. Saltin B, Blomqvist G, Mitchell JH, Johnson RL Jr, Wildenthal K, Chapman CB. Response to exercise after bed rest and after training. Circulation 38: VII1-VII78, 1968.
43. Saltin B, Nazar K, Costill DL, Stein E, Jansson E, Essen B, Gollnick D. The nature of the training response; peripheral and central adaptations of one-legged exercise. Acta Physiol Scand 96: 289-305, 1976.
44. Seals DR, Victor RG. Regulation of muscle sympathetic nerve activity during exercise in humans. Exerc Sport Sci Rev 19: 313-349, 1991.
45. Sennepin AD, Charpentier Sp Normand T, Sarré C, Legrand A, Mollet LM. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Anal Biochem 393: 129-131, 2009.
46. Strange S. Cardiovascular control during concomitant dynamic leg exercise and static arm exercise in humans. J Physiol 514: 283-291, 1999.
47. Thomas GD, Hansen J, Victor RG. Inhibition of alpha 2-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle. Am J Physiol Heart Circ Physiol 266: H920-H929, 1994.
48. Thomas GD, Segal SS. Neural control of muscle blood flow during exercise. J Appl Physiol 97: 731-738, 2004.
49. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, Joyner MJ. Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541: 623-635, 2002.
50. Vongpatanasin W, Wang Z, Arbique D, Arbique G, Adams-Huet B, Mitchell JH, Victor RG, Thomas GD. Functional sympatholysis is impaired in hypertensive humans. J Physiol 589: 1209-1220, 2011.
51. Wray DW, Donato AJ, Nishiyama SK, Richardson RS. Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans. J Appl Physiol 102: 704-712, 2007.