Moral decision-making, ToM, empathy and the default mode network

Biological Psychology

Volumn 90, Issue 3, 2012, Pages 202-210

  Reniers, Renate L E P ^a   Corcoran, Rhiannon ^a   Völlm, Birgit A ^a   Mashru, Asha ^a   Howard, Richard ^a   Liddle, Peter F ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Default mode network; Empathy; FMRI; Moral decision making; Psychopathy; ToM

Indexed keywords

ADULT; ARTICLE; BOLD SIGNAL; BRAIN FUNCTION; COMPARATIVE STUDY; COMPETENCE; CORRELATION ANALYSIS; DECISION MAKING; DEFAULT MODE NETWORK; EMPATHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL FUNCTION; MORALITY; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOPATHY; SELF CONCEPT; SOCIAL BELIEF; THEORY OF MIND;

ADOLESCENT; ADULT; ANTISOCIAL PERSONALITY DISORDER; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; DECISION MAKING; EDUCATIONAL STATUS; EMPATHY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; JUDGMENT; MAGNETIC RESONANCE IMAGING; MALE; MORALS; NERVE NET; NEUROPSYCHOLOGICAL TESTS; OXYGEN; REACTION TIME; SOCIOECONOMIC FACTORS; THEORY OF MIND; YOUNG ADULT;

EID: 84861168021     PISSN: 03010511     EISSN: 18736246     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2012.03.009     Document Type: Article

References (79)

1. Adolphs R. Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience 2003, 4(3):165-178.
2. Ammons R.B., Ammons C.H. The Quick Test 1962, Psychological Test Specialists, Missoula, MT.
3. Anderson S.W., Bechara A., Damasio H., Tranel D., Damasio A.R. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature Neuroscience 1999, 2(11):1032-1037.
4. Andrews-Hanna J.R., Reidler J.S., Sepulcre J., Poulin R., Buckner R.L. Functional-anatomic fractionation of the brain's default network. Neuron 2010, 65(4):550-562.
5. Ashburner J., Friston K.J. Unified segmentation. Neuroimage 2005, 26(3):839-851.
6. Baron-Cohen S., Richler J., Bisarya D., Gurunathan N., Wheelwright S. The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences 2003, 358(1430):361-374.
7. Blair R.J. A cognitive developmental approach to mortality: investigating the psychopath. Cognition 1995, 57(1):1-29.
8. Brinkley C.A., Schmitt A.S., Smith S.S., Newman J.P. Construct validation of a self-report psychopathy scale: does Levenson's self-report psychopathy scale measure the same constructs as Hare's psychopathy checklist-revised?. Personality and Individual Differences 2001, 31:1021-1038.
9. Cale E.M., Lilienfeld S.O. What every forensic psychologist should know about psychopathic personality. Handbook of Forensic Psychology: Resource for Mental Health and Legal Professionals 2004, Elsevier Inc. W.T. O'Donohue, E.R. Levensky (Eds.).
10. Cavanna A.E., Trimble M.R. The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006, 129(Pt 3):564-583.
11. Christoff K., Gabrieli J.D.E. The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex. Psychobiology 2000, 28(2):168-186.
12. Christoff K., Ream J.M., Geddes L.P., Gabrieli J.D. Evaluating self-generated information: anterior prefrontal contributions to human cognition. Behavioral Neuroscience 2003, 117(6):1161-1168.
13. Ciaramelli E., Muccioli M., Ladavas E., di Pellegrino G. Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Social Cognitive and Affective Neuroscience 2007, 2(2):84-92.
14. Cima M., Tonnaer F., Hauser M.D. Psychopaths know right from wrong but don't care. Social Cognitive and Affective Neuroscience 2010, 5(1):59-67.
15. Corbetta M., Shulman G.L. Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience 2002, 3(3):201-215.
16. Corcoran R. The allusive cognitive deficit in paranoia: the case for mental time travel or cognitive self-projection. Psychological Medicine 2010, 40(8):1233-1237.
17. D'Argembeau A., Collette F., Van der Linden M., Laureys S., Del Fiore G., Degueldre C., et al. Self-referential reflective activity and its relationship with rest: a PET study. Neuroimage 2005, 25(2):616-624.
18. D'Argembeau A., Ruby P., Collette F., Degueldre C., Balteau E., Luxen A., et al. Distinct regions of the medial prefrontal cortex are associated with self-referential processing and perspective taking. Journal of Cognitive Neuroscience 2007, 19(6):935-944.
19. D'Argembeau A., Stawarczyk D., Majerus S., Collette F., Van der Linden M., Salmon E. Modulation of medial prefrontal and inferior parietal cortices when thinking about past, present, and future selves. Social Neuroscience 2010, 5(2):187-200.
20. Eisenberg N. Emotion, regulation and moral development. Annual Review of Psychology 2000, 51:665-697.
21. Eslinger P.J., Robinson-Long M., Realmuto J., Moll J., De Oliveira-Souza R., Tovar-Moll F. Developmental frontal lobe imaging in moral judgment: Arthur Benton's enduring influence 60 years later. Journal of Clinical and Experimental Neuropsychology 2009, 31(2):158-169.
22. Farrow T.F., Zheng Y., Wilkinson I.D., Spence S.A., Deakin J.F., Tarrier N., et al. Investigating the functional anatomy of empathy and forgiveness. Neuroreport 2001, 12(11):2433-2438.
23. Friston K.J., Worsley K.J., Frackowiak R.S.J., Mazziotta J.C., Evans A.C. Assessing the significance of focal activations using their spatial extent. Human Brain Mapping 1994, 1:210-220.
24. Frith U., Frith C.D. Development and neurophysiology of mentalizing. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences 2003, 358(1431):459-473.
25. Fukui H., Murai T., Shinozaki J., Aso T., Fukuyama H., Hayashi T., et al. The neural basis of social tactics: an fMRI study. Neuroimage 2006, 32(2):913-920.
26. Fumagalli M., Ferrucci R., Mameli F., Marceglia S., Mrakic-Sposta S., Zago S., et al. Gender-related differences in moral judgments. Cognitive Processing 2010, 11(3):219-226.
27. Gilbert S.J., Burgess P.W. Executive function. Current Biology 2008, 18(3):R110-R114.
28. Glenn A.L., Raine A., Schug R.A., Young L., Hauser M. Increased DLPFC activity during moral decision-making in psychopathy. Molecular Psychiatry 2009, 14:909-911.
29. Gobbini M.I., Koralek A.C., Bryan R.E., Montgomery K.J., Haxby J.V. Two takes on the social brain: a comparison of theory of mind tasks. Journal of Cognitive Neuroscience 2007, 19(11):1803-1814.
30. Gowland P.A., Bowtell R. Theoretical optimization of multi-echo fMRI data acquisition. Physics in Medicine and Biology 2007, 52(7):1801-1813.
31. Greene J.D., Nystrom L.E., Engell A.D., Darley J.M., Cohen J.D. The neural bases of cognitive conflict and control in moral judgment. Neuron 2004, 44:389-400.
32. Greene J.D., Sommerville R.B., Nystrom L.E., Darley J.M., Cohen J.D. An fMRI investigation of emotional engagement in moral judgment. Science 2001, 293(5537):2105-2108.
33. Gusnard D.A., Akbudak E., Shulman G.L., Raichle M.E. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(7):4259-4264.
34. Hare R.D. Hare Psychopathy Checkllist-Revised (PCL-R). Technical Manual 2003, Multi-Health Systems, North Tonawanda, NY. 2nd ed.
35. Harenski C.L., Antonenko O., Shane M.S., Kiehl K.A. A functional imaging investigation of moral deliberation and moral intuition. Neuroimage 2010, 49(3):2707-2716.
36. Harrison B.J., Pujol J., Lopez-Sola M., Hernandez-Ribas R., Deus J., Ortiz H., et al. Consistency and functional specialization in the default mode brain network. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(28):9781-9786.
37. Huebner B., Dwyer S., Hauser M. The role of emotion in moral psychology. Trends in Cognitive Sciences 2009, 13(1):1-6.
38. Hynes C.A., Baird A.A., Grafton S.T. Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking. Neuropsychologia 2006, 44(3):374-383.
39. Intrator J., Hare R.D., Stritzke P., Brichtswein K., Dorfman D., Harpur T., et al. A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biological Psychiatry 1997, 42:96-103.
40. Karpman B. On the need for separating psychopathy into two distinct clinical types: symptomatic and idiopathic. Journal of Criminology and Psychopathology 1941, 3:112-137.
41. Kiehl K.A., Smith A.M., Hare R.D., Mendrek A., Forster B.B., Brink J., et al. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry 2001, 50(9):677-684.
42. Knobe J. Theory of mind and moral cognition: exploring the connections. Trends in Cognitive Sciences 2005, 9(8):357-359.
43. Lane R.D., Reiman E.M., Bradley M.M., Lang P.J., Ahern G.L., Davidson R.J., et al. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia 1997, 35(11):1437-1444.
44. Leiberg S., Anders S. The multiple facets of empathy: a survey of theory and evidence. Progress in Brain Research 2006, 156:419-440.
45. Levenson M.R., Kiehl K.A., Fitzpatrick C.M. Assessing psychopathic attributes in a noninstitutionalized population. Journal of Personality and Social Psychology 1995, 68(1):151-158.
46. Lind G. The meaning and measurement of moral judgment competence revisited: a dual-aspect model. Contemporary Philosophical and Psychological Perspectives on Moral Development and Education 2002, Hampton Press, Cresskill, NJ. D. Fasko, W. Willis (Eds.).
47. Lind G. The cross-cultural validity of the moral judgment test: findings from 28 cross-cultural studies. Paper presented at the American Psychological Association 2005.
48. Wie misst man moralisches Urteil? Probleme und alternative Moglichkeiten der Messung eines komplexen Konstrukts 1978, Beltz, Weinheim. G. Lind (Ed.).
49. The Meaning and Measurement of Moral Judgment Competence: A Dual-Aspect Model 2008, Hampton Press., Cresskill, New York. G. Lind (Ed.).
50. Luo Q., Nakic M., Wheatley T., Richell R., Martin A., Blair R.J. The neural basis of implicit moral attitude-an IAT study using event-related fMRI. Neuroimage 2006, 30(4):1449-1457.
51. Lynam D.R., Whiteside S., Jones S. Self-reported psychopathy: a validation study. Journal of Personality Assessment 1999, 73(1):110-132.
52. Mantini D., Perrucci M.G., Del Gratta C., Romani G.L., Corbetta M. Electrophysiological signatures of resting state networks in the human brain. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(32):13170-13175.
53. Mason R.A., Just M.A. Differentiable cortical networks for inferences concerning people's intentions versus physical causality. Human Brain Mapping 2011, 32(2):313-329.
54. Miller J.D., Gaughan E.T., Pryor L.R. The Levenson Self-Report Psychopathy scale: an examination of the personality traits and disorders associated with the LSRP factors. Assessment 2008, 15(4):450-463.
55. Moll J., De Oliveira-Souza R., Bramati I.E., Grafman J. Functional networks in emotional moral and nonmoral social judgments. Neuroimage 2002, 16:696-703.
56. Moll J., de Oliveira-Souza R., Eslinger P.J. Morals and the human brain: a working model. Neuroreport 2003, 14(3):299-305.
57. Moll J., De Oliveira-Souza R., Eslinger P.J., Bramati I.E., Mourao-Miranda J., Andreiuolo P.A., et al. The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. The Journal of Neuroscience 2002, 22(7):2730-2736.
58. Moll J., de Oliveira-Souza R., Garrido G.J., Bramati I.E., Caparelli-Daquer E.M., Paiva M.L., et al. The self as a moral agent: linking the neural bases of social agency and moral sensitivity. Social Neuroscience 2007, 2(3-4):336-352.
59. Moll J., Eslinger P.J., De Oliveira-Souza R. Frontopolar and anterior temporal cortex activation in a moral judgment task. Arquivos de Neuro-psiquiatria 2001, 59(3-B):657L 664.
60. Northoff G., Heinzel A., de Greck M., Bermpohl F., Dobrowolny H., Panksepp J. Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 2006, 31(1):440-457.
61. Prehn K., Wartenburger I., Meriau K., Scheibe C., Goodenough O.R., Villringer A., et al. Individual differences in moral judgment competence influence neural correlates of socio-normative judgments. SCAN 2008, 3:33-46.
62. Qin P., Northoff G. How is our self related to midline regions and the default-mode network?. Neuroimage 2011, 57(3):1221-1233.
63. Raichle M.E., Snyder A.Z. A default mode of brain function: a brief history of an evolving idea. Neuroimage 2007, 37(4):1083-1090. (discussion 1097-1089).
64. Reniers R.L.E.P. Components of Empathy and Impulsivity: Functional Neuroanatomy and Implications for Psychopathy 2010, University of Manchester, Manchester.
65. Reniers R.L.E.P., Corcoran R., Drake R., Shryane N.M., Völlm B.A. The QCAE: a questionnaire of cognitive and affective empathy. Journal of Personality Assessment 2011, 93(1):84-95.
66. Schafer J.L., Olsen M.K. Multiple imputation for multivariate missing-data problems: a data analyst's perspective. Multivariate Behavioral Research 1998, 33(4):545-571.
67. Schaich Borg J., Sinnott-Armstrong W., Calhoun V.D., Kiehl K.A. Neural basis of moral verdict and moral deliberation. Social Neuroscience 2011, 6(4):398-413.
68. Shamay-Tsoory S.G., Tomer R., Berger B.D., Aharon-Peretz J. Characterization of empathy deficits following prefrontal brain damage: the role of the right ventromedial prefrontal cortex. Journal of Cognitive Neuroscience 2003, 15(3):324-337.
69. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry 1998, 59(Suppl. 20):22-33.
70. Sheng T., Gheytanchi A., Aziz-Zadeh L. Default network deactivations are correlated with psychopathic personality traits. PLoS One 2010, 5(9):e12611.
71. Shulman G.L., Astafiev S.V., McAvoy M.P., d'Avossa G., Corbetta M. Right TPJ deactivation during visual search: functional significance and support for a filter hypothesis. Cerebral Cortex 2007, 17(11):2625-2633.
72. Spreng R.N., Mar R.A., Kim A.S. The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis. Journal of Cognitive Neuroscience 2009, 21(3):489-510.
73. Talairach J., Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain 1988, Thieme Medical Publishers, Inc., New York. 1st ed.
74. Völlm B.A., Taylor A.N., Richardson P., Corcoran R., Stirling J., McKie S., et al. Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 2006, 29(1):90-98.
75. Vreeke G.J., van der Mark I.L. Empathy an integrative model. New Ideas in Psychology 2003, 21:177-207.
76. Whitfield-Gabrieli S., Moran J.M., Nieto-Castanon A., Triantafyllou C., Saxe R., Gabrieli J.D. Associations and dissociations between default and self-reference networks in the human brain. Neuroimage 2011, 55(1):225-232.
77. Young L., Bechara A., Tranel D., Damasio H., Hauser M., Damasio A. Damage to ventromedial prefrontal cortex impairs judgment of harmful intent. Neuron 2010, 65(6):845-851.
78. Young L., Koenigs M. Investigating emotion in moral cognition: a review of evidence from functional neuroimaging and neuropsychology. British Medical Bulletin 2007, 84:69-79.
79. Ziefle M. Effects of display resolution on visual performance. Human Factors 1998, 40(4):554-568.