Serious medical complications in children with cancer and fever in chemotherapy-induced neutropenia: Results of the prospective multicenter SPOG 2003 FN study

Pediatric Blood and Cancer

Volumn 59, Issue 1, 2012, Pages 90-95

  Lüthi, Fabienne ^a   Leibundgut, Kurt ^a   Niggli, Felix K ^b   Nadal, David ^b   Aebi, Christoph ^a   Bodmer, Nicole ^b   Ammann, Roland A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cancer; Children; Death; Fever and neutropenia; Intensive care unit; Life threatening complication

Indexed keywords

ANTINEOPLASTIC AGENT; HEMOGLOBIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; ATYPICAL TERATOID RHABDOID TUMOR; CANCER CHEMOTHERAPY; CANCER MORTALITY; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHILDHOOD CANCER; CHILDHOOD DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG INDUCED DISEASE; EWING SARCOMA; FEBRILE NEUTROPENIA; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTENSIVE CARE UNIT; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROBLASTOMA; NONHODGKIN LYMPHOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RHABDOID TUMOR; RHABDOMYOSARCOMA; SCHOOL CHILD; SERIOUS MEDICAL COMPLICATION; SOLID TUMOR;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; FEMALE; FEVER; GERMANY; HUMANS; INTENSIVE CARE UNITS; LEUKEMIA, MYELOID, ACUTE; MALE; NEUTROPENIA; PROSPECTIVE STUDIES; SURVIVAL RATE; SWITZERLAND;

EID: 84861100864     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23277     Document Type: Article

References (34)

1. Freycon F, Trombert-Paviot B, Casagranda L, et al. Trends in treatment-related deaths (TRDs) in childhood cancer and leukemia over time: A follow-up of patients included in the Childhood Cancer Registry of the Rhône-Alpes region in France (ARCERRA). Pediatr Blood Cancer 2008; 50: 1213-1220.
2. Sung L, Nathan PC, Lange B, et al. Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: A meta-analysis of randomized controlled trials. J Clin Oncol 2004; 22: 3350-3356.
3. Wittman B, Horan J, Lyman GH. Prophylactic colony-stimulating factors in children receiving myelosuppressive chemotherapy: A meta-analysis of randomized controlled trials. Cancer Treat Rev 2006; 32: 289-303.
4. Wicki S, Keisker A, Aebi C, et al. Risk prediction of fever in neutropenia in children with cancer: A step towards individually tailored supportive therapy? Pediatr Blood Cancer 2008; 51: 778-783.
5. Laws HJ, Ammann RA, Lehrnbecher T. Diagnostic procedures and management of fever in pediatric cancer patients. Klin Pädiatr 2005; 1: 9-16.
6. Kuderer NM, Dale DC, Crawford J, et al. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 2006; 106: 2258-2266.
7. Lucas KG, Brown AE, Armstrong D, et al. The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis. Cancer 1996; 77: 791-798.
8. Wacker P, Halperin DS, Wyss M, et al. Early hospital discharge of children with fever and neutropenia: A prospective study. J Pediatr Hematol Oncol 1997; 19: 208-211.
9. Hann I, Viscoli C, Paesmans M, et al. A comparison of outcome from febrile neutropenic episodes in children compared with adults: Results from four EORTC studies. Br J Haematol 1997; 99: 580-588.
10. Baorto EP, Aquino VM, Mullen CA, et al. Clinical parameters associated with low bacteremia risk in 1100 pediatric oncology patients with fever and neutropenia. Cancer 2001; 92: 909-913.
11. Alexander SW, Wade KC, Hibberd PL, et al. Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer. J Pediatr Hematol Oncol 2002; 24: 38-42.
12. Ammann RA, Hirt A, Ridolfi Lüthy A, et al. Identification of children presenting with fever in chemotherapy-induced neutropenia at low risk for severe bacterial infection. Med Pediatr Oncol 2003; 41: 436-443.
13. Basu SK, Fernandez ID, Fisher SG, et al. Length of stay and mortality associated with febrile neutropenia among children with cancer. J Clin Oncol 2005; 23: 7958-7966.
14. Hakim H, Flynn PM, Knapp KM, et al. Etiology and clinical course of febrile neutropenia in children with cancer. J Pediatr Hematol Oncol 2009; 31: 623-629.
15. West DC, Marcin JP, Mawis R, et al. Children with cancer, fever, and treatment-induced neutropenia: Risk factors associated with illness requiring the administration of critical care therapies. Pediatr Emerg Care 2004; 20: 79-84.
16. Feld R. Criteria for response in patients in clinical trials of empiric antibiotic regimens for febrile neutropenia. Is there agreement? Support Care Cancer 1998; 6: 444-448.
17. Slater A, Shann F, Pearson G. Paediatric Index of Mortality (PIM) Study Group. PIM2: A revised version of the Paediatric Index of Mortality. Intensive Care Med 2003; 29: 278-285.
18. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6: 2-8.
19. Zhang H, Singer B. Recursive partitioning in the health sciences. New York: Springer; 1999. p. 226.
20. Ammann RA, Bodmer N, Hirt A, et al. Predicting adverse events in children with fever and chemotherapy-induced neutropenia: The prospective multicenter SPOG 2003 FN study. J Clin Oncol 2010; 28: 2008-2014.
21. Agyeman P, Aebi C, Hirt A, et al. Predicting bacteremia in children with cancer and fever in chemotherapy-induced neutropenia. Results of the prospective multicenter SPOG 2003 FN study. Pediatr Infect Dis J 2011; 30: e114-e119.
22. Klastersky J, Paesmans M, Rubinstein EB, et al. The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 2000; 18: 3038-3051.
23. Steiner I, Aebi C, Ridolfi Lüthy A, et al. Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2007; 50: 647-649.
24. Santolaya ME, Alvarez AM, Becker A, et al. Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever. J Clin Oncol 2001; 19: 3415-3421.
25. Santolaya ME, Alvarez AM, Avilés CL, et al. Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia. Clin Infect Dis 2002; 35: 678-683.
26. Rondinelli PI, Ribeiro Kde C, de Camargo B. A proposed score for predicting severe infection complications in children with chemotherapy-induced febrile neutropenia. J Pediatr Hematol Oncol 2006; 28: 665-670.
27. Paganini HR, Aguirre C, Puppa G, et al. A prospective, multicentric scoring system to predict mortality in febrile neutropenic children with cancer. Cancer 2007; 109: 2572-2579.
28. Meyer S, Gottschling S, Biran T, et al. Assessing the risk of mortality in paediatric cancer patients admitted to the paediatric intensive care unit: A novel risk score? Eur J Pediatr 2005; 164: 563-567.
29. Pound CM, Johnston DL, Armstrong R, et al. The morbidity and mortality of pediatric oncology patients presenting to the intensive care unit with septic shock. Pediatr Blood Cancer 2008; 51: 584-588.
30. Dursun O, Hazar V, Karasu GT, et al. Prognostic factors in pediatric cancer patients admitted to the pediatric intensive care unit. J Pediatr Hematol Oncol 2009; 31: 481-484.
31. Santolaya ME, Alvarez AM, Avilés CL, et al. Admission clinical and laboratory factors associated with death in children with cancer during a febrile neutropenic episode. Pediatr Infect Dis J 2007; 26: 794-798.
32. Santolaya ME, Alvarez AM, Aviles CL, et al. Predictors of severe sepsis not clinically apparent during the first twenty-four hours of hospitalization in children with cancer, neutropenia, and fever: A prospective, multicenter trial. Pediatr Infect Dis J 2008; 27: 538-543.
33. te Poele EM, Tissing WJE, Kamps WA, et al. Risk assessment in fever and neutropenia in children with cancer: What did we learn? Crit Rev Oncol Hematol 2009; 72: 45-55.
34. Hakim H, Flynn PM, Srivastava DK, et al. Risk prediction in pediatric cancer patients with fever and neutropenia. Pediatr Infect Dis J 2010; 29: 53-59.