Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase

Planta Medica

Volumn 78, Issue 7, 2012, Pages 672-677

  Coulerie, Paul ^a   Eydoux, Cécilia ^b   Hnawia, Edouard ^a   Stuhl, Laetitia ^b   MacIuk, Alexandre ^c   Lebouvier, Nicolas ^a   Canard, Bruno ^b   Figadère, Bruno ^c   Guillemot, Jean Claude ^b   Nour, Mohammed ^a  

^a UNIVERSITÉ DE LA NOUVELLE CALÉDONIE   (New Caledonia)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UNIVERSITÉ PARIS SUD   (France)

Author keywords

biflavonoids; Dacrydium balansae; dengue virus; DV NS5 RdRp; Podocarpaceae

Indexed keywords

3 HYDROXYSTIGMAST 5 EN 7 ONE; 6 HYDROXYSTIGMAST 4 EN 3 ONE; AMENTOFLAVONE; APIGENIN; BIFLAVONOID; CIS 3,5,4 TRIMETHOXYSTILBENE; HINOKIFLAVONE; NONSTRUCTURAL PROTEIN 5; RNA POLYMERASE; SITOSTEROL; STEROL DERIVATIVE; STILBENE DERIVATIVE; TRANS3,5,4 TRIMETHOXYSTILBENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMOTHERAPY; CONTROLLED STUDY; DACRYDIUM BALANSAE; DENGUE; DENGUE VIRUS 2; ENZYME ACTIVITY; FLAVIVIRUS; IC 50; MEDICINAL PLANT; NONHUMAN; REPLICON;

ANTIVIRAL AGENTS; BIFLAVONOIDS; CONIFEROPHYTA; DENGUE VIRUS; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; NEW CALEDONIA; PHYTOTHERAPY; PLANT BARK; PLANT LEAVES; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

DACRYDIUM BALANSAE; DENGUE VIRUS; DENGUE VIRUS TYPE 2; FLAVIVIRIDAE; PODOCARPACEAE;

EID: 84861100682     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298355     Document Type: Article

References (21)

1. Ghosh D, Basu A. Present perspectives on flaviviral chemotherapy. Drug Discov Today 2008 13 619-624
2. Knipe D. Field's virology, 5th edition. Philadelphia Lippincott Williams & Wilkins 2007 1409-1439
3. Tomlinson S M., Watowich S J. Anthracene-based inhibitors of dengue virus NS2B-NS3 protease. Antiviral Res 2011 89 127-135
4. Bollati M, Alvarez K, Assenberg R, Baronti C, Canard B, Cook S, Coutard B, Decroly E, de Lamballerie X, Gould E A., Grard G, Grimes J M., Hilgenfeld R, Jansson A M., Malet H, Mancini E J., Mastrangelo E, Mattevi A, Milani M, Moureau G, Neyts J, Owens R J., Ren J, Selisko B, Speroni S, Steuber H, Stuart D I., Unge T, Bolognesi M. Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res 2010 87 125-148
5. Selisko B, Dutartre H, Guillemot J C., Debarnot C, Benarroch D, Khromykh A, Desprès P, Egloff M P., Canard B. Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology 2006 351 145-158 (Pubitemid 44056063)
6. Malet H, Massé N, Selisko B, Romette J L., Alvarez K, Guillemot J C., Tolou H, Yap T L., Vasudevan S, Lescar J, Canard B. The flavivirus polymerase as a target for drug discovery. Antiviral Res 2008 80 23-35
7. Myers N, Mittermeier R A., Mittermeier C G., da Fonseca G A. B., Ken J. Biodiversity hotspots for conservation priorities. Nature 2000 403 853-858 (Pubitemid 30130979)
8. Paeshuyse J, Letellier C, Froeyen M, Dutartre H, Vrancken R, Canard B, De Clercq E, Gueiffier A, Teulade J C., Herdewijn P, Puerstinger G, Koenen F, Kerkhofs P, Baraldi P G., Neyts J. A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase. Antiviral Res 2009 82 141-147
9. Massé N, Davidson A, Ferron F, Alvarez K, Jacobs M, Romette J L., Canard B, Guillemot J C. Dengue virus replicons: production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity. Antiviral Res 2010 86 296-305
10. Della Greca M, Monaco P, Previtera L. Stigmasterols from Typha latifolia. J Nat Prod 1990 53 1430-1435
11. Georges P, Sylvestre M, Ruegger H, Bourgeois P. Ketosteroids and hydroxyketosteroids, minor metabolites of sugarcane wax. Steroids 2006 71 647-652
12. 13C NMR studies of some naturally occuring amentoflavone, and hinokiflavone biflavonoids. Phytochemistry 1987 26 3335-3337
13. McCarthy F O., Chopra J, Ford A, Hogan S A., Kerry J P., O'Brien N M., Ryan E, Maquire A R. Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives. Org Biomol Chem 2005 3 3059-3065 (Pubitemid 41239085)
14. Murias M, Handler N, Erker T, Pleban K, Ecker G, Saiko P, Szekeres T, Jäger W. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 2004 12 5571-5578 (Pubitemid 39304056)
15. pro inhibition. Bioorg Med Chem 2010 18 7940-7947
16. Schneider Y, Chabert P, Stutzmann J, Coelho D, Fougerousse A, Gossé F, Launay J F., Brouillard R, Raul F. Resveratrol analog (Z)-3, 5, 4-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. Int J Cancer 2003 107 189-196 (Pubitemid 37152896)
17. Berry K M., Perry N B., Weavers R T. Foliage sesquiterpenes of Dacrydium cupressinum identification, variation and biosynthesis. Phytochemistry 1985 24 2893-2898
18. Quinn C J., Gadek P. Biflavones of Dacrydium sensu lato. Phytochemistry 1981 20 677-681
19. Chong J, Poutaraud A, Hugueney P. Metabolism and roles of stilbenes in plants. Plant Sci 2009 177 143-155
20. Koonin E. The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J Gen Virol 1991 72 2197-2206
21. Havsteen B H. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 2002 96 67-202 (Pubitemid 35356564)