Subclinical capillary changes in non-proliferative diabetic retinopathy

Optometry and Vision Science

Volumn 89, Issue 5, 2012, Pages

  Tam, Johnny ^a   Dhamdhere, Kavita P ^b   Tiruveedhula, Pavan ^b   Lujan, Brandon J ^b,c   Johnson, Robert N ^c   Bearse, Marcus A ^b   Adams, Anthony J ^b   Roorda, Austin ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WEST COAST RETINA MEDICAL GROUP   (United States)

Author keywords

adaptive optics; capillaries; diabetic retinopathy; leukocyte; microaneurysm; photoreceptors

Indexed keywords

CAPILLARIES; DIABETIC RETINOPATHY; LEUKOCYTE; MICROANEURYSMS; PHOTORECEPTORS;

ADAPTIVE OPTICS; ANGIOGRAPHY; BLOOD VESSELS; EYE PROTECTION; NONINVASIVE MEDICAL PROCEDURES; VISION;

CAPILLARITY;

ADULT; ARTICLE; CAPILLARY; CASE REPORT; DIABETIC RETINOPATHY; DISEASE COURSE; EYE FUNDUS; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METHODOLOGY; OPHTHALMOSCOPY; PATHOLOGY; RETINA BLOOD VESSEL; RETINA CONE; RETINA FOVEA; VASCULARIZATION;

ADULT; CAPILLARIES; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; DISEASE PROGRESSION; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; FOVEA CENTRALIS; FUNDUS OCULI; HUMANS; MALE; OPHTHALMOSCOPY; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL VESSELS;

EID: 84861099003     PISSN: 10405488     EISSN: None     Source Type: Journal    
DOI: 10.1097/OPX.0b013e3182548b07     Document Type: Article

References (30)

1. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1984;102:520-6. (Pubitemid 14127838)
2. Hellstedt T, Immonen I. Disappearance and formation rates of mi-croaneurysms in early diabetic retinopathy. Br J Ophthalmol 1996; 80:135-9. (Pubitemid 26058546)
3. Zhang Y, Poonja S, Roorda A. MEMS-based adaptive optics scanning laser ophthalmoscopy. Opt Lett 2006;31:1268-70. (Pubitemid 43901262)
4. Roorda A, Romero-Borja F, Donnelly W, III, Queener H, Hebert T, Campbell M. Adaptive optics scanning laser ophthalmoscopy. Opt Express 2002;10:405-12.
5. Tam J, Martin JA, Roorda A. Noninvasive visualization and analysis of parafoveal capillaries in humans. Invest Ophthalmol Vis Sci 2010; 51:1691-8.
6. Nelson DA, Krupsky S, Pollack A, Aloni E, Belkin M, Vanzetta I, Rosner M, Grinvald A. Special report: noninvasive multi-parameter functional optical imaging of the eye. Ophthalmic Surg Lasers Imaging 2005;36:57-66. (Pubitemid 40128602)
7. Schmoll T, Singh AS, Blatter C, Schriefl S, Ahlers C, Schmidt-Erfurth U, Leitgeb RA. Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension. Biomed Opt Express 2011;2:1159-68.
8. Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser SE, Werner JS. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci 2012;53:85-92.
9. Zhong Z, Petrig BL, Qi X, Burns SA. In vivo measurement of eryth-rocyte velocity and retinal blood flow using adaptive optics scanning laser ophthalmoscopy. Opt Express 2008;16:12746-56.
10. Tam J, Tiruveedhula P, Roorda A. Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope. Biomed Opt Express 2011;2: 781-93
11. Sander B, Larsen M, Engler C, Lund-Andersen H, Parving HH. Early changes in diabetic retinopathy: capillary loss and blood-retina barrier permeability in relation to metabolic control. Acta Ophthalmol (Co-penh) 1994;72:553-9. (Pubitemid 24370763)
12. Arend O, Wolf S, Jung F, Bertram B, Postgens H, Toonen H, Reim M. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol 1991;75:514-8.
13. Arend O, Wolf S, Remky A, Sponsel WE, Harris A, Bertram B, Reim M. Perifoveal microcirculation with non-insulin-dependent diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 1994;232:225-31. (Pubitemid 24127410)
14. Gray DC, Merigan W, Wolfing JI, Gee BP, Porter J, Dubra A, Twietmeyer TH, Ahamd K, Tumbar R, Reinholz F, Williams DR. In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells. Opt Express 2006;14:7144-58. (Pubitemid 44188516)
15. Kwan AS, Barry C, McAllister IL, Constable I. Fluorescein angiogra-phy and adverse drug reactions revisited: the Lions Eye experience. Clin Experiment Ophthalmol 2006;34:33-8. (Pubitemid 43379368)
16. Tam J, Dhamdhere KP, Tiruveedhula P, Manzanera S, Barez S, Bearse MA, Jr., Adams AJ, Roorda A. Disruption of the retinal para-foveal capillary network in type 2 diabetes before the onset of diabetic retinopathy. Invest Ophthalmol Vis Sci 2011;52:9257-66.
17. Rodieck RW. The density recovery profile: a method for the analysis of points in the plane applicable to retinal studies. Vis Neurosci 1991;6:95-111.
18. Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KE, Swaroop A, Roorda A. High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci 2007;48:3283-91. (Pubitemid 351261175)
19. Tam J, Roorda A. Speed quantification and tracking of moving objects in adaptive optics scanning laser ophthalmoscopy. J Biomed Opt 2011;16:036002.
20. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs\an extension of the modified Airlie House classification. ETDRS report number 10. Ophthalmology 1991; 98: 786-806.
21. Michaelson IC, Campbell ACP. The anatomy of the finer retinal vessels. Trans Ophthalmol Soc UK 1940;60:71-112.
22. Li KY, Tiruveedhula P, Roorda A. Intersubject variability of foveal cone photoreceptor density in relation to eye length. Invest Ophthalmol Vis Sci 2010;51:6858-67.
23. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photo-receptor topography. J Comp Neurol 1990;292:497-523.
24. Cunha-Vaz J, Bernardes R. Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes. Prog Retin Eye Res 2005;24:355-77. (Pubitemid 40238669)
25. Boeri D, Maiello M, Lorenzi M. Increased prevalence of microthrom-boses in retinal capillaries of diabetic individuals. Diabetes 2001;50: 1432-9. (Pubitemid 32500177)
26. Mansour AM, Schachat A, Bodiford G, Haymond R. Foveal avascu-lar zone in diabetes mellitus. Retina 1993;13:125-8. (Pubitemid 23177776)
27. Conrath J, Giorgi R, Raccah D, Ridings B. Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment. Eye (Lond) 2005;19:322-6. (Pubitemid 40484828)
28. Bresnick GH, Condit R, Syrjala S, Palta M, Groo A, Korth K. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol 1984;102:1286-93. (Pubitemid 14071827)
29. Chibber R, Ben-Mahmud BM, Chibber S, Kohner EM. Leukocytes in diabetic retinopathy. Curr Diabetes Rev 2007;3:3-14. (Pubitemid 46592789)
30. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:283-90. (Pubitemid 36351495)