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this very important multicenter, prospective, randomized trial, patients who had a baseline systolic blood pressure of > 160 mm Hg despite treatment with three or more antihypertensive drugs were randomly allocated to renal denervation plus previous treatment n=52 or to a control group n=51 that maintained previous treatment alone. At 6 months of follow-up, office-based blood pressure measurements in the renal denervation group fell by an average of 32/12 mm Hg from a baseline of 178/96 mm Hg P< 0.0001, whereas it did not differ from baseline in the control group. The results show that catheter-based renal denervation can safely be used to substantially reduce blood pressure in treatmentresistant hypertensive patients
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Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomized controlled trial. Lancet. 2010;376:1903-9. In this very important multicenter, prospective, randomized trial, patients who had a baseline systolic blood pressure of > 160 mm Hg despite treatment with three or more antihypertensive drugs were randomly allocated to renal denervation plus previous treatment (n=52) or to a control group (n=51) that maintained previous treatment alone. At 6 months of follow-up, office-based blood pressure measurements in the renal denervation group fell by an average of 32/12 mm Hg from a baseline of 178/96 mm Hg (P< 0.0001), whereas it did not differ from baseline in the control group. The results show that catheter-based renal denervation can safely be used to substantially reduce blood pressure in treatmentresistant hypertensive patients.
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Catheter-based renal sympathetic denervation for resistant hypertension: Durability of blood pressure reduction out to 24 months
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Symplicity HTN-1 Investigators, This study demonstrated the durability of blood pressure reduction after renal denervation. Inpatients with drug-resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in blood pressure that was sustained out to > 2 years of follow-up, without significant adverse events
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Symplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension: Durability of blood pressure reduction out to 24 months. Hypertension 2011;57:911-917. This study demonstrated the durability of blood pressure reduction after renal denervation. Inpatients with drug-resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in blood pressure that was sustained out to > 2 years of follow-up, without significant adverse events.
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(2011)
Hypertension
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