Isolated left ventricular noncompaction: What do we really know?

Current Cardiology Reports

Volumn 14, Issue 3, 2012, Pages 381-388

  Peters, Ferande ^a   Khandheria, Bijoy K ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Diagnostic criteria; Echocardiography; Isolated left ventricular noncompaction

Indexed keywords

ANTICOAGULANT AGENT;

ANTICOAGULANT THERAPY; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CARDIOVASCULAR MAGNETIC RESONANCE; CONGESTIVE CARDIOMYOPATHY; DEFIBRILLATOR; ECHOCARDIOGRAPHY; EMBRYO DEVELOPMENT; GENE MUTATION; GENETIC SCREENING; HEART ARRHYTHMIA; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART TRANSPLANTATION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; PATHOGENESIS; PEDIGREE ANALYSIS; PREVALENCE; PROGNOSIS; SUDDEN DEATH; TACHYCARDIA; THROMBOEMBOLISM; VENTRICULAR NONCOMPACTION; X CHROMOSOMAL INHERITANCE;

DIAGNOSIS, DIFFERENTIAL; HUMANS; ISOLATED NONCOMPACTION OF THE VENTRICULAR MYOCARDIUM; MAGNETIC RESONANCE IMAGING; MUTATION; PROGNOSIS; STROKE VOLUME;

EID: 84861096383     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-012-0255-0     Document Type: Article

References (58)

1. Maron BJ, Towbin JA, Thiene G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113:1807-16.
2. Chin TK, Perloff JK, Williams RG, et al. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation. 1990;82:507-13.
3. Bernanke DH, Velkey JM. Development of the coronary blood supply: changing concepts and current ideas. Anat Rec. 2002;269:198-208.
4. Agmon Y, Connolly HM, Olson LJ, et al. Noncompaction of the ventricular myocardium. J Am Soc Echocardiogr. 1999;12:859-63.
5. Freedom RM, Yoo SJ, Perrin D, et al. The morphological spectrum of ventricular noncompaction. Cardiol Young. 2005;15:345-64.
6. Weiford BC, Subbarao VD, Mulhern KM. Noncompaction of the ventricular myocardium. Circulation. 2004;109:2965-71.
7. Allenby PA, Gould NS, Schwartz MF, Chiemmongkoltip P. Dysplastic cardiac development presenting as cardiomyopathy. Arch Pathol Lab Med. 1988;112:1255-8.
8. Ichida F. Left ventricular noncompaction. Circ J. 2009;73:19-26.
9. Bleyl SB, Mumford BR, Brown-Harrison MC, et al. Xq28-linked noncompaction of the left ventricular myocardium: prenatal diagnosis and pathologic analysis of affected individuals. Am J Med Genet. 1997;72:257-65.
10. Finsterer J, Stöllberger C, Gaismayer K, Janssen B. Acquired noncompaction in Duchenne muscular dystrophy. Int J Cardiol. 2006;106:420-1.
11. Pfammatter JP, Paul T, Flik J, et al. Q-fever associated myocarditis in a 14-year-old boy. Z Kardiol. 1995;84:947-50. German.
12. Rehfeldt KH, Pulido JN, Mauermann WJ, Click RL. Left ventricular hypertrabeculation/noncompaction in a patient with peripartum cardiomyopathy. Int J Cardiol. 2010;139:e18-20.
13. Engberding R, Stöllberger C, Ong P, et al. Isolated noncompaction cardiomyopathy. Dtsch Arztebl Int. 2010;107:206-13.
14. Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000;36:493-500.
15. Hoedemaekers YM, Caliskan K, Michels M, et al. The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy. Circ Cardiovasc Genet. 2010;3:232-9.
16. Lofiego C, Biagini E, Ferlito M, et al. Paradoxical contributions of non-compacted and compacted segments to global left ventricular dysfunction in isolated left ventricular noncompaction. Am J Cardiol. 2006;97:738-41.
17. Probst S, Oechslin E, Schuler P, et al. Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype. Circ Cardiovasc Genet. 2011;4:367-74.
18. Murphy RT, Thaman R, Blanes JG, et al. Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J. 2005;26:187-92.
19. Burke A, Mont E, Kutys R, Virmani R. Left ventricular noncompaction: a pathological study of 14 cases. Hum Pathol. 2005;36:403-11.
20. Espinola-Zavaleta N, Soto ME, Castellanos LM, et al. Noncompacted cardiomyopathy: clinical-echocardiographic study. Cardiovasc Ultrasound. 2006;4:35.
21. Stöllberger C, Winkler-Dworak M, Blazek G, Finsterer J. Prognosis of left ventricular hypertrabeculation/noncompaction is dependent on cardiac and neuromuscular comorbidity. Int J Cardiol. 2007;121:189-93.
22. Aras D, Tufekcioglu O, Ergun K, et al. Clinical features of isolated ventricular noncompaction in adults long-term clinical course, echocardiographic properties, and predictors of left ventricular failure. J Card Fail. 2006;12:726-33.
23. Sengupta PP, Mohan JC, Mehta V, et al. Comparison of echocardiographic features of noncompaction of the left ventricle in adults versus idiopathic dilated cardiomyopathy in adults. Am J Cardiol. 2004;94:389-91.
24. Sato Y, Matsumoto N, Matsuo S, et al. Isolated noncompaction of the ventricular myocardium in a 94-year-old patient: depiction at echocardiography and magnetic resonance imaging. Int J Cardiol. 2007;119:e32-4.
25. Pignatelli RH, McMahon CJ, Dreyer WJ, et al. Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation. 2003;108:2672-8.
26. Junga G, Kneifel S, Von Smekal A, et al. Myocardial ischaemia in children with isolated ventricular non-compaction. Eur Heart J. 1999;20:910-6.
27. Ichida F, Hamamichi Y, Miyawaki T, et al. Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol. 1999;34:233-40.
28. Jenni R, Wyss CA, Oechslin EN, Kaufmann PA. Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol. 2002;39:450-4.
29. Ritter M, Oechslin E, Sütsch G, et al. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc. 1997;72:26-31.
30. Ichida F, Tsubata S, Bowles KR, et al. Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation. 2001;103:1256-63.
31. Steffel J, Hürlimann D, Namdar M, et al. Long-term follow-up of patients with isolated left ventricular noncompaction: role of electrocardiography in predicting poor outcome. Circ J. 2011;75:1728-34.
32. Jenni R, Oechslin EN, van der Loo B. Isolated ventricular noncompaction of the myocardium in adults. Heart. 2007;93:11-5.
33. Stöllberger C, Finsterer J, Blazek G. Left ventricular hypertrabeculation/noncompaction and association with additional cardiac abnormalities and neuromuscular disorders. Am J Cardiol. 2002;90:899-902.
34. Bellavia D, Michelena HI, Martinez M, et al. Speckle myocardial imaging modalities for early detection of myocardial impairment in isolated left ventricular non-compaction. Heart. 2010;96:440-7.
35. Stanton C, Bruce C, Connolly H, et al. Isolated left ventricular noncompaction syndrome. Am J Cardiol. 2009;104:1135-8.
36. Hook S, Ratliff NB, Rosenkranz E, Sterba R. Isolated noncompaction of the ventricular myocardium. Pediatr Cardiol. 1996;17:43-5.
37. Ciurzynski M, Lichodziejewska B, Tomaszewski A, et al. Biventricular noncompaction associated with left ventricular systolic and diastolic dysfunction and severe pulmonary hypertension in a young man. Circ J. 2009;73:2163-5.
38. Jayan P, Shankarappa RK, Ananthakrishna R, Nanjappa MC. Isolated left ventricular noncompaction mimicking ventricular mass. Echocardiography. 2011;28:E137-9.
39. Baker GH, Pereira NL, Hlavacek AM, et al. Transthoracic realtime three-dimensional echocardiography in the diagnosis and description of noncompaction of ventricular myocardium. Echocardiography. 2006;23:490-4.
40. van Dalen BM, Caliskan K, Soliman OI, et al. Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and quantitative functional diagnostic criterion? Eur J Heart Fail. 2008;10:1088-93.
41. van Dalen BM, Caliskan K, Soliman OI, et al. Diagnostic value of rigid body rotation in noncompaction cardiomyopathy. J Am Soc Echocardiogr. 2011;24:548-55. This study suggests that RBR is a common abnormality in ILVNC and may be used as an additional functional criterion.
42. Boyd MT, Seward JB, Tajik AJ, Edwards WD. Frequency and location of prominent left ventricular trabeculations at autopsy in 474 normal human hearts: implications for evaluation of mural thrombi by two-dimensional echocardiography. J Am Coll Cardiol. 1987;9:323-6.
43. Tamborini G, Pepi M, Celeste F, et al. Incidence and characteristics of left ventricular false tendons and trabeculations in the normal and pathologic heart by second harmonic echocardiography. J Am Soc Echocardiogr. 2004;17:367-74.
44. Dawson DK, Maceira AM, Raj VJ, et al. Regional thicknesses and thickening of compacted and trabeculated myocardial layers of the normal left ventricle studied by cardiovascular magnetic resonance. Circ Cardiovasc Imaging. 2011;4:139-46. This study provides insight into normal LVarchitecture on MRI.
45. Kohli SK, Pantazis AA, Shah JS, et al. Diagnosis of leftventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur Heart J. 2008;29:89-95. This study highlights the limitations of current diagnostic criteria in patients with heart failure. In addition, it highlights the possibility of lack of specificity in Afro-Caribbean patients.
46. Jenni R, Oechslin E, Schneider J, et al. Echocardiographic and pathoanatomical characteristics of isolated left ventricular noncompaction: a step towards classification as a distinct cardiomyopathy. Heart. 2001;86:666-71.
47. Stöllberger C, Grassberger M, Finsterer J. Left ventricular noncompaction/hypertrabeculation: distinctive entity or abnormality, frequently associated with neuromuscular disorders? Am J Cardiol. 2011;108:1200-1.
48. Saleeb SF, Margossian R, Spencer CT, et al.: Reproducibility of echocardiographic diagnosis of left ventricular noncompaction. J Am Soc Echocardiogr. 2011, In press. This study highlights the poor reproducibility of existing echocardiographic criteria for diagnosis of ILVNC.
49. Alhabshan F, Smallhorn JF, Golding F, et al. Extent of myocardial non-compaction: comparison between MRI and echocardiographic evaluation. Pediatr Radiol. 2005;35:1147-51.
50. Petersen SE, Selvanayagam JB, Wiesmann F, et al. Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol. 2005;46:101-5.
51. Habib G, Charron P, Eicher JC, et al. Isolated left ventricular noncompaction in adults: clinical and echocardiographic features in 105 patients. Results from a French registry. Eur J Heart Fail. 2011;13:177-85.
52. Daimon Y, Watanabe S, Takeda S, et al. Two-layered appearance of noncompaction of the ventricular myocardium on magnetic resonance imaging. Circ J. 2002;66:619-21.
53. Nucifora G, Aquaro GD, Pingitore A, et al. Myocardial fibrosis in isolated left ventricular non-compaction and its relation to disease severity. Eur J Heart Fail. 2011;13:170-6.
54. Leung SW, Elayi CS, Charnigo RJ Jr, Syed MA: Clinical significance of right ventricular dysfunction in left ventricular noncompaction cardiomyopathy. Int J Cardiovasc Imaging. 2011, In press.
55. Stöllberger C, Blazek G, Winkler-Dworak M, Finsterer J. Atrial fibrillation in left ventricular noncompaction with and without neuromuscular disorders is associated with a poor prognosis. Int J Cardiol. 2009;133:41-5.
56. Greutmann M, Mah ML, Silversides CK, et al.: Predictors of adverse outcome in adolescents and adults with isolated left ventricular noncompaction. Am J Cardiol. 2011, In press.
57. Bertini M, Ziacchi M, Biffi M, et al. Effects of cardiac resynchronisation therapy on dilated cardiomyopathy with isolated ventricular non-compaction. Heart. 2011;97:295-300.
58. Epstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;51:e1-e62.