Failure to reduce C-reactive protein levels more than 25% in the last 24 hours before intensive care unit discharge predicts higher in-hospital mortality: A cohort study

Journal of Critical Care

Volumn 27, Issue 5, 2012, Pages 525.e9-525.e15

  Ranzani, Otavio T ^a   Prada, Luis F ^a   Zampieri, Fernando G ^a   Battaini, Ligia C ^a   Pinaffi, Juliana V ^a   Setogute, Yone C ^a   Salluh, Jorge I F ^c   Povoa, Pedro ^d,e   Forte, Daniel N ^a,b   Azevedo, Luciano C P ^a,b   Park, Marcelo ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL SÍRIO LIBANÊS   (Brazil)

^c D OR INSTITUTE FOR RESEARCH AND EDUCATION IDOR   (Brazil)

^d HOSPITAL DE SÃO FRANCISCO XAVIER   (Portugal)

^e UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Biomarkers; C reactive protein; Hospital mortality; ICU discharge; Intensive care unit; Outcome

Indexed keywords

C REACTIVE PROTEIN;

ADULT; ARTICLE; COHORT ANALYSIS; FEMALE; HOSPITAL DISCHARGE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; SURVIVOR;

EID: 84861095013     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2011.10.013     Document Type: Article

References (29)

1. Moreno R., Agthe D. ICU discharge decision-making: are we able to decrease post-ICU mortality?. Intensive Care Med 1999, 25(10):1035-1036.
2. Goldhill D.R., Sumner A. Outcome of intensive care patients in a group of British intensive care units. Crit Care Med 1998, 26(8):1337-1345.
3. Daly K., Beale R., Chang R.W. Reduction in mortality after inappropriate early discharge from intensive care unit: logistic regression triage model. BMJ 2001, 322(7297):1274-1276.
4. Gajic O., Malinchoc M., Comfere T.B., et al. The Stability and Workload Index for Transfer score predicts unplanned intensive care unit patient readmission: initial development and validation. Crit Care Med 2008, 36(3):676-682.
5. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine Guidelines for intensive care unit admission, discharge, and triage. Crit Care Med 1999, 27(3):633-638.
6. Povoa P. C-reactive protein: a valuable marker of sepsis. Intensive Care Med 2002, 28(3):235-243.
7. Lobo S.M., Lobo F.R., Bota D.P., et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest 2003, 123(6):2043-2049.
8. Grander W., Dunser M., Stollenwerk B., et al. C-reactive protein levels and post-ICU mortality in nonsurgical intensive care patients. Chest 2010, 138(4):856-862.
9. Ho K.M., Lee K.Y., Dobb G.J., et al. C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study. Intensive Care Med 2008, 34(3):481-487.
10. Silvestre J., Coelho L., Povoa P. Should C-reactive protein concentration at ICU discharge be used as a prognostic marker?. BMC Anesthesiol 2010, 10:17.
11. Al Subaie N., Reynolds T., Myers A., et al. C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study. Br J Anaesth 2010, 105(3):318-325.
12. Michard F., Boussat S., Chemla D., et al. Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. Am J Respir Crit Care Med 2000, 162(1):134-138.
13. Ferreira F.L., Bota D.P., Bross A., et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001, 286(14):1754-1758.
14. Park M., Azevedo L.C., Maciel A.T., et al. Evolutive standard base excess and serum lactate level in severe sepsis and septic shock patients resuscitated with early goal-directed therapy: still outcome markers?. Clinics 2006, 61(1):47-52.
15. Coelho L., Povoa P., Almeida E., et al. Usefulness of C-reactive protein in monitoring the severe community-acquired pneumonia clinical course. Crit Care 2007, 11(4):R92.
16. Yentis S.M., Soni N., Sheldon J. C-reactive protein as an indicator of resolution of sepsis in the intensive care unit. Intensive Care Med 1995, 21(7):602-605.
17. Povoa P., Coelho L., Almeida E., et al. Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study. Crit Care 2006, 10(2):R63.
18. Moreno M.S., Nietmann H., Matias C.M., et al. C-reactive protein: a tool in the follow-up of nosocomial pneumonia. J Infect 2010, 61(3):205-211.
19. Seligman R., Meisner M., Lisboa T.C., et al. Decreases in procalcitonin and C-reactive protein are strong predictors of survival in ventilator-associated pneumonia. Crit Care 2006, 10(5):R125.
20. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13(10):818-829.
21. Vincent J.L., de Mendonca A., Cantraine F., et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998, 26(11):1793-1800.
22. Schroeder M.A. Diagnosing and dealing with multicollinearity. West J Nurs Res 1990, 12(2):175-184.
23. van den B.G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354(5):449-461.
24. Claeys R., Vinken S., Spapen H., et al. Plasma procalcitonin and C-reactive protein in acute septic shock: clinical and biological correlates. Crit Care Med 2002, 30(4):757-762.
25. Povoa P., Coelho L., Almeida E., et al. Pilot study evaluating C-reactive protein levels in the assessment of response to treatment of severe bloodstream infection. Clin Infect Dis 2005, 40(12):1855-1857.
26. Kaben A., Correa F., Reinhart K., et al. Readmission to a surgical intensive care unit: incidence, outcome and risk factors. Crit Care 2008, 12(5):R123.
27. Ho K.M., Dobb G.J., Lee K.Y., et al. C-reactive protein concentration as a predictor of intensive care unit readmission: a nested case-control study. J Crit Care 2006, 21(3):259-265.
28. Lobo S.M. C-reactive protein to predict intensive care unit readmission?. J Crit Care 2006, 21(3):265-266.
29. Azoulay E., Adrie C., de Lassence A., et al. Determinants of postintensive care unit mortality: a prospective multicenter study. Crit Care Med 2003, 31(2):428-432.