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in press. This randomized controlled trial of prophylactic cefoxitin in nulliparas receiving epidural analgesia showed no reduction in the rate of intrapartum fever in the cefoxitin group, despite an association between fever and placental inflammation. This provides further evidence for a noninfectious, inflammatory cause for epidural fever
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This case-control study comparing women with and without exposure to highdose oxytocin in the midtrimester found a net decrease in maternal temperature with high dose oxytocin exposure. This study suggests that exposure to oxytocin is not responsible for the increased rate of intrapartum fever observed in women receiving epidural analgesia
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Frolich MA, Esame A, Warren WM, Owen J. High dose oxytocin is not associated with maternal temperature elevation; a retrospective cohort study of mid-trimester pregnancy with intrauterine fetal demise. Int J ObstetAnesth 2011;20:30-33. This case-control study comparing women with and without exposure to highdose oxytocin in the midtrimester found a net decrease in maternal temperature with high dose oxytocin exposure. This study suggests that exposure to oxytocin is not responsible for the increased rate of intrapartum fever observed in women receiving epidural analgesia.
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This study reported an association between placental inflammation and an increased risk of fetal acidosis, suggesting that these findings are not independent. This finding lends increased weight to reports of an increased risk of neonatal encephalopathy, with and without acidosis, in women with intrapartum fever
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This study provides further evidence that adverse neonatal outcomes at term related to epidural analgesia are limited to those neonates exposed to maternal hyperthermia. The use of epidural analgesia in the absence of fever is not associated with adverse neonatal outcome
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Influence of epidural dexamethasone on maternal temperature and serum cytokine concentration after labor epidural analgesia
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This small-randomized controlled trial suggests that epidural dexamethasone can prevent or dampen the increase in maternal temperature following epidural analgesia as well as decrease the maternal inflammatory response. Larger studies are needed to elucidate the most effective dose as well as to establish neonatal safety
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Wang LZ, Hu XX, Liu X, et al. Influence of epidural dexamethasone on maternal temperature and serum cytokine concentration after labor epidural analgesia. Int J GynecolObstet 2011;113:40-43. This small-randomized controlled trial suggests that epidural dexamethasone can prevent or dampen the increase in maternal temperature following epidural analgesia as well as decrease the maternal inflammatory response. Larger studies are needed to elucidate the most effective dose as well as to establish neonatal safety.
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