Aortic atherosclerosis and embolic events

Current Cardiology Reports

Volumn 14, Issue 3, 2012, Pages 342-349

  Saric, Muhamed ^a,c   Kronzon, Itzhak ^b,d  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LENOX HILL HOSPITAL   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d Lenox Hill Interventional Cardiac and Vascular Services   (United States)

Author keywords

3D echocardiography; Aorta; Atheroembolism; Atheroma; Atherosclerosis; Cholesterol embolization syndrome; Computed tomography; Magnetic resonance imaging; Plaque; Stroke; Thromboembolism; Transesophageal echocardiography; Transient ischemic attack

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CHOLESTEROL; CLOPIDOGREL; FIBRINOLYTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; WARFARIN;

ANGIOSCOPY; AORTA ATHEROSCLEROSIS; AORTA INTIMA; AORTA THROMBOSIS; AORTOGRAPHY; ARTERY BYPASS; ARTERY OCCLUSION; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE REGULATION; CHOLESTEROL EMBOLISM; COMPUTER ASSISTED TOMOGRAPHY; ECHOGRAPHY; ENDARTERECTOMY; EPIAORTIC ECHOGRAPHY; GOLD STANDARD; HEART INFARCTION; HUMAN; INFLAMMATION; INTESTINE ISCHEMIA; KIDNEY FAILURE; KIDNEY INFARCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; RISK MANAGEMENT; SMOKING CESSATION; STENT; STROKE; THROMBOEMBOLISM; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSIENT ISCHEMIC ATTACK; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

AORTIC DISEASES; ATHEROSCLEROSIS; ECHOCARDIOGRAPHY, TRANSESOPHAGEAL; EMBOLISM; HUMANS; ISCHEMIC ATTACK, TRANSIENT; STROKE;

EID: 84861092274     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-012-0261-2     Document Type: Article

References (49)

1. Haller, Albrecht von. Observatio XXXXVII: materia ossium morbosorum. In: Opuscula pathologica. Lausanne: Bousquet; 1755. p. 124-8.
2. Lobstein J G C F M. Traités d'anatomie pathologique. Paris: Chez F. G. Levrault; 1833. p. 550-3.
3. Marchand JF. Über arteriosklerose (athero-sklerose). Verh Kongresses Innere Medizin. 1904;21:23-59.
4. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III). JAMA. 2001;285:2486-249.
5. Selzman CH, Miller SA, Harken AH. Therapeutic implications of inflammation in atherosclerotic cardiovascular disease. Ann Thorac Surg. 2001;71(6):2066-74.
6. Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799-809.
7. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull Jr W, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92(5):1355-74.
8. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey DE Jr, Eagle KA, Hermann LK, Isselbacher EM, Kazerooni EA, Kouchoukos NT, Lytle BW, Milewicz DM, Reich DL, Sen S, Shinn JA, Svensson LG, Williams DM; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines; American Association for Thoracic Surgery; American College of Radiology; American Stroke Association; Society of Cardiovascular Anesthesiologists; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of Thoracic Surgeons; Society for Vascular Medicine. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. J Am Coll Cardiol. 2010 Apr. 6;55(14):e27-129. This paper provides an extensive review of aortic atherosclerosis and the latest guidelines for its management.
9. Golledge J, Norman PE. Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors? Arterioscler Thromb Vasc Biol. 2010;30(6):1075-7.
10. Kronzon I, Saric M. Cholesterol embolization syndrome. Circulation. 2010;122:631-41. This article provides an exhaustive review of cholesterol embolization syndrome, which together with thromboembolism, is the major manifestation of aortic atherosclerosis.
11. Tunick PA, Kronzon I. Atheromas of the thoracic aorta: clinical and therapeutic update. J Am Coll Cardiol. 2000;35:545-54.
12. Fenger CE, Jacobsen JP, Dahlerup EA, Hornemann E, Collin T. Beretning af Obductionen over Albert Thorvaldsen (autopsy report of Albert Thorvaldsen). Ugeskr Laeger. 1844; X (14-15): 215-8.
13. Panum PL. Experimentelle Beiträge zur Lehre von der Embolie. Virchows Arch Pathol Anat Physiol. 1862;25:308-10.
14. Tunick PA, Katz ES, Freedberg RS, Rosezweig BP, Perez JL, Kronzon I. High risk vascular events in patients with protruding aortic atheromas: a prospective study. J Am Coll Cardiol. 1994;23:1085-90.
15. Stern A, Tunick PA, Culliford AT, Lachmann J, Baumann FG, Kanchuger M, Marschall K, Shah A, Grossi E, Kronzon I. Protruding aortic arch atheromas: risk of stroke during heart surgery with and without aortic arch endarterectomy. Am Heart J. 1999;138:746-52.
16. Rodés-Cabau J, Dumont E, Boone RH, Larose E, Bagur R, Gurvitch R Bédard F, Doyle D, De Larochellière R, Jayasuria C, Villeneuve J, Marrero A, Côté M, Pibarot P, Webb JG Cerebral embolism following transcatheter aortic valve implantation: comparison of transfemoral and transapical approaches. J Am Coll Cardiol. 2011;57(1):18-28.
17. Szeto WY, Augoustides JG, Desai ND, Moeller P, McGarvey ML, Walsh E, Bannan A, Herrmann HC, Bavaria JE. Cerebral embolic exposure during transfemoral and transapical transcatheter aortic valve replacement. J Card Surg. 2011;26(4):348-54.
18. Saric M, Kronzon I. Cholesterol embolization syndrome. Curr Opin Cardiol. 2011;26:472-9.
19. Rana BS, Monaghan MJ, Ring L, Shapiro LS, Nihoyannopoulos P. The pivotal role of echocardiography in cardiac sources of embolism. Eur J Echocardiogr. 2011;12(10):i25-31.
20. Pepi M, Evangelista A, Nihoyannopoulos P, Flachskampf FA, Athanassopoulos G, Colonna P, Habib G, Ringelstein EB, Sicari R Zamorano JL, Sitges M, Caso P; European Association of Echocardiography Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr. 2010 Jul; 11(6):461-76. These are the latest guidelines for the use of echocardiography for the detection of cardiac and aortic sources of emboli.
21. Davila-Roman VG, Phillips KJ, Daily BB, Davila RM, Kouchoukos NT, Barzilai B. Intraoperative transesophageal echocardiography and epiaortic ultrasound for assessment of atherosclerosis of the thoracic aorta. J Am Coll Cardiol. 1996;28:942-7.
22. Amarenco P, Cohen A, Tzourio C, Bertrand B, Hommel M, Besson G, Chauvel C, Touboul PJ, Bousser MG. Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med. 1994;331(22):1474-9.
23. Sharma U, Tak T. Aortic atheromas: current knowledge and controversies: a brief review of the literature. Echocardiogr. 2011;28(10):1157-63.
24. Ko Y, Park JH, Yang MH, Ko SB, Choi SI, Chun EJ, Han MK, Bae HJ. Significance of aortic atherosclerotic disease in possibly embolic stroke: 64-multidetector row computed tomography study. J Neurol. 2010;257(5):699-705.
25. Zahuranec DB, Mueller GC, Bach DS, Stojanovska J, Brown DL, Lisabeth LD, Patel S, Hughes RM, Attili AK, Armstrong WF, Morgenstern LB. Pilot study of cardiac magnetic resonance imaging for detection of embolic source after ischemic stroke. J Stroke Cerebrovasc Dis. 2011 Jun. 1. [Epub ahead of print].
26. Barazangi N, Wintermark M, Lease K, Rao R, Smith W, Josephson SA. Comparison of computed tomography angiography and transesophageal echocardiography for evaluating aortic arch disease. J Stroke Cerebrovasc Dis. 2011;20(5):436-42.
27. Khatri IA, Mian N, Al-Kawi A, Janjua N, Kirmani JF, Saric M, Levine JC, Qureshi AI. Arch aortogram fails to identify aortic atherosclerotic lesions detected on transesophageal echocardiogram. J Neuroimaging. 2005;15:1-5.
28. Dunphy MP, Freiman A, Larson SM, Strauss HW. Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med. 2005;46(8):1278-84.
29. Harloff A, Simon J, Brendecke S, Assefa D, Helbing T, Frydrychowicz A, Weber J, Olschewski M, Strecker C, Hennig J, Weiller C, Markl M. Complex plaques in the proximal descending aorta: an underestimated embolic source of stroke. Stroke. 2010;41(6):1145-50.
30. Saric M, Kronzon I. Embolism from aortic plaque: atheroembolism (cholesterol crystal embolism). In: Basow DS, editor. UpTo-Date. Waltham: UpToDate; 2011.
31. Tunick PA, Nayar AC, Goodkin GM, Mirchandani S, Francescone S, Rosenzweig BP, Freedberg RS, Katz ES, Applebaum RM, Kronzon I. Effect of treatment on the incidence of stroke and other emboli in 519 patients with severe thoracic aortic plaque. Am J Cardiol. 2002;90:1320-5.
32. American Heart Association website: http://www.strokeassociation.org/ STROKEORG/AboutStroke/About-Stroke-UCM-308529-SubHomePage.jsp accessed February 25, 2012.
33. Adams Jr HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh 3rd EE. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41.
34. Estol CJ. Dr C. Miller Fisher and the history of carotid artery disease. Stroke. 1996;27(3):559-66.
35. Chiari H. Ueber Verhalten des Teilungswinkels der Carotis Communis bei der Endarteritis Chronica Deformans. Verh Dtsch Ges Pathol. 1905;9:326.
36. Kronzon I, Tunick PA. Transesophageal echocardiography as a tool in the evaluation of patients with embolic disorders. Prog Cardiovasc Dis. 1993;36:39-60.
37. Sacco RL, Ellenberg JH, Mohr JP, Tatemichi TK, Hier DB, Price TR, Wolf PA. Infarcts of undermined cause: the NINCDS stroke data bank. Ann Neurol. 1989;25:382-90.
38. Tunick PA, Kronzon I. Protruding atherosclerotic plaque in the aortic arch of patients with systemic embolization: a new finding seen by transesophageal echocardiography. AM Heart J. 1990;120:658-60.
39. Kronzon I, Tunick PA. Atheromatous disease of the thoracic aorta: pathologic and clinical implications. Ann Intern Med. 1997;126:629-37.
40. Vaduganathan P, Ewton A, Nagueh SF, Weilbaecher DG, Safi HJ, Zoghbi WA. Pathologic correlates of aortic plaques, thrombi and mobile "aortic debris" imaged in vivo with transesophageal echocardiography. J Am Coll Cardiol. 1997;30(2):357-63.
41. Ezzeddine MA, Primavera JM, Rosand J, Hedley-Whyte ET, Rordorf G. Clinical characteristics of pathologically proved cholesterol emboli to the brain. Neurology. 2000;54:1681-3.
42. Hollenhorst RW. Significance of bright plaques in the retinal arterioles. JAMA. 1961;178:23-9.
43. Bunt TJ. The clinical significance of the asymptomatic Hollenhorst plaque. J Vasc Surg. 1986;4(6):559-62.
44. Scolari F, Ravani P, Gaggi R, Santostefano M, Rollino C, Stabellini N, Colla L, Viola BF, Maiorca P, Venturelli C, Bonardelli S, Faggiano P, Barrett BJ. The challenge of diagnosing atheroembolic renal disease: clinical features and prognostic factors. Circulation. 2007;116:298-304.
45. Moolenaar W, Lamers C B H W. Cholesterol crystal embolization and the digestive system. Scand J Gastroenterol. 1991;26 suppl 188:69-72.
46. Falanga V, Fine MJ, Kapoor WN. The cutaneous manifestations of cholesterol crystal embolization. Arch Dermatol. 1986;122:1194-9.
47. Karmody AM, Powers SR, Monaco VJ, Leather RP 'Blue toe' syndrome: an indication for limb salvage surgery. Arch Surg. 1976;111:1263-8.
48. http://clinicaltrials.gov/ct2/show/NCT00235248 Accessed February 25, 2012.
49. Wolf PS, Burman HE, Starnes BW. Endovascular treatment of massive thoracic aortic thrombus and associated ruptured atheroma. Ann Vasc Surg. 2010;24(3):416.e9-416.e12.