Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial

Journal of Clinical Periodontology

Volumn 39, Issue 6, 2012, Pages 574-581

  Hallström, Hadar ^a   Persson, G Rutger ^b,c,d   Lindgren, Susann ^a   Olofsson, Maria ^a   Renvert, Stefan ^b,e,f  

^a Hospital of Halland   (Sweden)

^b KRISTIANSTAD UNIVERSITY   (Sweden)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF BERN   (Switzerland)

^e TRINITY COLLEGE DUBLIN   (Ireland)

^f BLEKINGE INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

antibiotics; microbiology; peri implant disease; peri implant mucositis; therapy

Indexed keywords

EID: 84861083002     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2012.01884.x     Document Type: Article

References (31)

1. Ata-Ali, J., Flichy-Fernández, A. J., Alegre-Domingo, T., Candel-Marti, M. E., Peñarrocha, D., Balaguer-Martinez, J., &, Peñarrocha, M. A., (2011) Analysis of the peri-implant microbiota in 90 dental implants and its relationship to crevicular fluid volume. Medicina oral, patología oral y cirugía bucal 16, e944-e947.
2. Ferreira, S. D., Silva, G. L., Cortelli, J. R., Costa, J. E., &, Costa, F. O., (2006) Prevalence and risk variables for peri-implant disease in Brazilian subjects. Journal of Clinical Periodontology 33, 929-935. (Pubitemid 44715432)
3. Fürst, M., Salvi, G. E., Lang, N. P., &, Persson, G. R., (2007) Bacterial colonization immediately after installation on oral titanium implants. Clinical Oral Implants Research 18, 501-508.
4. Girard, G., &, Bloemberg, G. V., (2008) Central role of quorum sensing in regulating the production of pathogenicity factors in Pseudomonas aeruginosa. Future Microbiology 3, 97-106. (Pubitemid 351395067)
5. Gomi, K., Yashima, A., Iino, F., Kanazashi, M., Nagano, T., Shibukawa, N., Ohshima, T., Maeda, N., &, Arai, T., (2007) Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. Journal of Periodontology 78, 918-923.
6. Haas, A. N., de Castro, G. D., Moreno, T., Susin, C., Albandar, J. M., Oppermann, R. V., &, Rösing, C. K., (2008) Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial. Journal of Clinical Periodontology 35, 696-704.
7. Heitz-Mayfield, L. J., Salvi, G. E., Botticelli, D., Mombelli, A., Faddy, M., Lang, N. P., & Implant Complication Research Group (2011) Anti-infective treatment of peri-implant mucositis: a randomised controlled clinical trial. Clinical Oral Implants Research 22, 237-241.
8. Khan, W. A., Saha, D., Rahman, A., Salam, M. A., Bogaerts, J., &, Bennish, M. L., (2002) Comparison of single-dose azithromycin and 12-dose, 3-day erythromycin for childhood cholera: a randomised, double-blind trial. Lancet 360, 1722-1727. (Pubitemid 35447901)
9. Lai, P. C., Ho, W., Jain, N., &, Walters, J. D., (2011) Azithromycin Concentrations in Blood and Gingival Crevicular Fluid After Systemic Administration. Journal of Periodontology 82, 1582-1586.
10. Lang, N. P., Berglundh, T., & Working Group 4 of Seventh European Workshop on Period ontology (2011) Periimplant diseases: where are we now?-Consensus of the Seventh European Workshop on Periodontology. Journal of Clinical Periodontology 38 (Suppl 11), 178-181.
11. Lindhe, J., Meyle, J., & Group D of European Workshop on Period ontology (2008) Peri-implant diseases: consensus Report of the Sixth European Workshop on Periodontology. Journal of Clinical Periodontology 35 (Suppl. 8), 282-285.
12. Maezono, H., Noiri, Y., Asahi, Y., Yamaguchi, M., Yamamoto, R., Izutani, N., Azakami, H., &, Ebisu, S., (2011) Anti-biofilm Effects of Azithromycin and Erythromycin on Porphyromonas gingivalis. Antimicrobial Agents and Chemotherapy 55, 5887-5892.
13. Mascarenhas, P., Gapski, R., Al-Shammari, K., Hill, R., Soehren, S., Fenno, J. C., Giannobile, W. V., &, Wang, H. L., (2005) Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers. Journal of Periodontology 76, 426-436. (Pubitemid 40668390)
14. Máximo, M. B., de Mendonça, A. C., Renata Santos, V., Figueiredo, L. C., Feres, M., &, Duarte, P. M., (2009) Short-term clinical and microbiological evaluations of peri-implant diseases before and after mechanical anti-infective therapies. Clinical Oral Implants Research 20, 99-108.
15. Oteo, A., Herrera, D., Figuero, E., O'Connor, A., González, I., &, Sanz, M., (2010) Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalis-associated periodontitis: a pilot study. Journal of Clinical Periodontology 37, 1005-1015.
16. Peltonen, L. I., Kinnari, T. J., Aarnisalo, A. A., Kuusela, P., &, Jero, J., (2007) Comparison of bacterial adherence to polylactides, silicone, and titanium. Acta Oto-Laryngologica 127, 587-593. (Pubitemid 46763710)
17. Persson, G. R., Hitti, J., Paul, K., Hirschi, R., Weibel, M., Rothen, M., &, Persson, R. E., (2008) Tannerella forsythia and Pseudomonas aeruginosa in subgingival bacterial samples from parous women. Journal of Periodontology 79, 508-516.
18. Persson, G. R., Samuelsson, E., Lindahl, C., &, Renvert, S., (2010) Mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. II. Microbiological results. Journal of Clinical Periodontology 37, 563-573.
19. Persson, G. R., Roos-Jansåker, A. M., Lindahl, C., &, Renvert, S., (2011) Microbiologic results after non-surgical erbium-doped:yttrium, aluminum, and garnet laser or air-abrasive treatment of peri-implantitis: a randomized clinical trial. Journal of Periodontology 82, 1267-1278.
20. Pradeep, A. R., Sagar, S. V., &, &Daisy, H., (2008) Clinical and microbiologic effects of subgingivally delivered 0.5% azithromycin in the treatment of chronic periodontitis. Journal of Periodontology 79, 2125-2135.
21. Quirynen, M., Vogels, R., Peeters, W., van Steenberghe, D., Naert, I., &, Haffajee, A., (2006) Dynamics of initial subgingival colonization of 'pristine' peri-implant pockets. Clinical Oral Implants Research 17, 25-37. (Pubitemid 43424597)
22. Renvert, S., Lessem, J., Dahlén, G., Renvert, H., &, Lindahl, C., (2008b) Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. Journal of Periodontology 79, 836-844.
23. Renvert, S., Roos-Jansåker, A. M., &, Claffey, N., (2008a) Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. Journal of Clinical Periodontology 35 (Suppl 8), 305-315.
24. Renvert, S., Roos-Jansåker, A. M., Lindahl, C., Renvert, H., &, Persson, G. R., (2007) Infection at titanium implants with or without a clinical diagnosis of inflammation. Clinical Oral Implants Research 18, 509-516.
25. Renvert, S., Samuelsson, E., Lindahl, C., &, Persson, G. R., (2009) Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results. Journal of Clinical Periodontology 36, 604-609.
26. Roos-Jansåker, A. M., Lindahl, C., Renvert, H., &, Renvert, S., (2006) Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. Journal of Clinical Periodontology 33, 290-295. (Pubitemid 43439346)
27. Smith, S. R., Foyle, D. M., Daniels, J., Joyston-Bechal, S., Smales, F. C., Sefton, A., &, Williams, J., (2002) A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results. Journal of Clinical Periodontology 29, 54-61. (Pubitemid 41697735)
28. Socransky, S. S., Haffajee, A. D., Smith, C., Martin, L., Haffajee, J. A., Uzel, N. G., &, Goodson, J. M., (2004) Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiology & Immunology 19, 352-362. (Pubitemid 39487668)
29. Thöne-Mühling, M., Swierkot, K., Nonnenmacher, C., Mutters, R., Flores-de-Jacoby, L., &, Mengel, R., (2010) Comparison of two full-mouth approaches in the treatment of peri-implant mucositis: a pilot study. Clinical Oral Implants Research 21, 504-512.
30. Yashima, A., Gomi, K., Maeda, N., &, Arai, T., (2009) One-stage full-mouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin. Journal of Periodontology 80, 1406-1413.
31. Zitzmann, N. U., &, Berglundh, T., (2008) Definition and prevalence of peri-implant diseases. Journal of Clinical Periodontology 35 (Suppl. 8), 286-229.